Activation of the hypothalamic–pituitary–adrenal axis by addictive drugs: different pathways, common outcome
Abstract
Addictive drugs (opiates, ethanol, cannabinoids (CBs), nicotine, cocaine, amphetamines) induce activation of the hypothalamic-pituitary-adrenal (HPA) axis, with the subsequent release of adrenocorticotropic hormone and glucocorticoids. The sequence of events leading to HPA activation appears to start within the brain, suggesting that activation is not secondary to peripheral homeostatic alterations. The precise neurochemical mechanisms and brain pathways involved are markedly dependent on the particular drug, although it is assumed that information eventually converges into the hypothalamic paraventricular nucleus (PVN). Whereas some drugs may act on the hypothalamus or directly within PVN neurons (i.e. ethanol), others exert their primary action outside the PVN (i.e. CBs, nicotine, cocaine). Corticotropin-releasing hormone (CRH) has a critical role in most cases, but the changes in c-fos and CRH gene expression in the PVN also reveal differences among drugs. More studies are needed to understand how addictive drugs act on this important neuroendocrine system and their functional consequences.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Drugs of abuse activate the hypothalamo-pituitary-adrenal (HPA) axis.
“drugs of abuse activate the hypothalamo-pituitary–adrenal (HPA) axis (Armario, 2010).”
From Stress- and Glucocorticoid-Induced Priming of Neuroinflammatory Responses: Potential Mechanisms of Stress-Induced Vulnerability to Drugs of Abuse (2011) · cites this paper as Armario, 2010
Cites
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614 · see citing works
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R. (1998) · Endocrine Reviews · doi:10.1210/er.19.3.269 · Cited by 2,614 · see citing works
Endocrinology of the stress response
Charmandari, E., Tsigos, C., & Chrousos, G. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040403.120816 · Cited by 1,799 · see citing works
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586 · see citing works
Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications
Mansour, A., Fox, C. A., Akil, H., & Watson, S. J. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93946-u · Cited by 1,297 · see citing works
Cota, D., Marsicano, G., Tschöp, M. H., Grübler, Y., Flachskamm, C., Schubert, M. I., Auer, D. P., Yassouridis, A., Thöne‐Reineke, C., Ortmann, S., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17725 · Cited by 1,168 · see citing works
A Role for Brain Stress Systems in Addiction
Koob, G. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.012 · Cited by 1,056 · see citing works
Di, S., Malcher‐Lopes, R., Halmos, K. C., & Tasker, J. G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-04850.2003 · Cited by 801 · see citing works
The effects of opioids and opioid analogs on animal and human endocrine systems
Vuong, C., Van Uum, S. H. M., O'Dell, L. E., Lutfy, K., & Friedman, T. C. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0009 · Cited by 564 · see citing works
Patel, S., Roelke, C. T., Rademacher, D. J., Cullinan, W. E., & Hillard, C. J. (2004) · Endocrinology · doi:10.1210/en.2004-0638 · Cited by 475 · see citing works
Corticosteroid hormones in the central stress response: Quick-and-slow
de Kloet, E. R., Karst, H., & Joëls, M. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.10.002 · Cited by 391 · see citing works
RIVIER, C. L., BRUHN, T. O., & Vale, W. G. (1984) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21776-1 · Cited by 328 · see citing works
Kovacs, K., & Sawchenko, P. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00262.1996 · Cited by 310 · see citing works
Hill, M. N., McLaughlin, R. J., Morrish, A. C., Viau, V., Floresco, S. B., Hillard, C. J., & Gorzalka, B. B. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.114 · Cited by 304 · see citing works
Richardson, H. N., Lee, S. Y., O’Dell, L. E., Koob, G. F., & Rivier, C. L. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06455.x · Cited by 294 · see citing works
Lightman, S. L., & Young, W. S. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017261 · Cited by 215 · see citing works
The Hypothalamic-Pituitary-Adrenal Axis: What can it Tell us About Stressors?
Armario, A. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706778559336 · Cited by 213 · see citing works
RIVIER, C. L., & Vale, W. W. (1987) · Brain Research · doi:10.1016/0006-8993(87)90953-x · Cited by 211 · see citing works
Hauger, R. L., MILLAN, M. A., Lorang, M. T., Harwood, J. P., & Aguilera, G. (1988) · Endocrinology · doi:10.1210/endo-123-1-396 · Cited by 202 · see citing works
RIVIER, C. L. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01636.x · Cited by 180 · see citing works
Nash, J. F., Meltzer, H., & Gudelsky, G. A. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24086-1 · Cited by 179 · see citing works
Weidenfeld, J., Feldman, S., & Mechoulam, R. (2008) · Neuroendocrinology · doi:10.1159/000126646 · Cited by 179 · see citing works
de Fonseca, F. R., Rubio, P., Menzaghi, F., Merlo‐Pich, E., Rivier, J., Koob, G. F., & Navarro, M. A. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12276-3 · Cited by 175 · see citing works
Ganon-Elazar, E., & Akirav, I. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1223-09.2009 · Cited by 173 · see citing works
Role of the endocannabinoid system in regulation of the hypothalamic-pituitary-adrenocortical axis
Steiner, M. S., & Wotjak, C. T. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00433-0 · Cited by 167 · see citing works
Pfeiffer, A. F. H., & Herz, A. (1984) · Hormone and Metabolic Research · doi:10.1055/s-2007-1014801 · Cited by 161 · see citing works
Buckingham, J. C. (2008) · Neuroendocrinology · doi:10.1159/000123364 · Cited by 160 · see citing works
Manzanares, J., Corchero, J., & Fuentes, J. A. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01756-4 · Cited by 152 · see citing works
RIVIER, C. L., & Lee, S. (1996) · Brain Research · doi:10.1016/0006-8993(96)00301-0 · Cited by 151 · see citing works
Quertemont, É., Tambour, S., & Tirelli, E. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.03.003 · Cited by 148 · see citing works
Response of the hypothalamo-pituitary-adrenal axis to nicotine
Matta, S. G., Fu, Y., Valentine, J. D., & Sharp, B. M. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(97)00079-6 · Cited by 139 · see citing works
Sarnyai, Z., Bíró, É., Penke, B., & Telegdy, G. (1992) · Brain Research · doi:10.1016/0006-8993(92)91176-f · Cited by 132 · see citing works
Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice
Steiner, M. A., Wanisch, K., Monory, K., Marsicano, G., Borroni, E., Bächli, H., Holsboer, F., Lutz, B., & Wotjak, C. T. (2007) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500466 · Cited by 123 · see citing works
Monoamine mediation of cocaine-induced hypothalamo-pituitary-adrenal activation.
Borowsky, B., & Kuhn, C. M. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22944-5 · Cited by 123 · see citing works
The Neuroendocrinology of the Adrenal Cortex
Vinson, G. P., Hinson, J. P., & Tóth, I. E. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00578.x · Cited by 109 · see citing works
Pituitary-adrenal axis responses to acute amphetamine in the rat
Swerdlow, N. R., Koob, G. F., Cador, M., Lorang, M. T., & Hauger, R. L. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90518-x · Cited by 105 · see citing works
Matta, S. G., Foster, C. A., & Sharp, B. M. (1993) · Endocrinology · doi:10.1210/endo.132.5.8386611 · Cited by 104 · see citing works
Effect of Amphetamine on Plasma Corticosterone in the Conscious Rat
Knych, E. T., & Eisenberg, R. M. (2008) · Neuroendocrinology · doi:10.1159/000122912 · Cited by 95 · see citing works
Fu, Y.-T., Matta, S. G., James, T. J., & Sharp, B. M. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37341-0 · Cited by 92 · see citing works
The role of CRF in the release of ACTH by opiate agonists and antagonists in rats
Nikolarakis, K. E., Pfeiffer, A. F. H., Stalla, G. K., & Herz, A. (1987) · Brain Research · doi:10.1016/0006-8993(87)91311-4 · Cited by 90 · see citing works
Nicotine elevates rat plasma ACTH by a central mechanism.
Matta, S. G., BEYER, H. S., McAllen, K., & Sharp, B. M. (1987) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39223-2 · Cited by 87 · see citing works
Cocaine stimulates rat hypothalamic corticotropin-releasing hormone secretion in vitro
Calogero, A. E., Gallucci, W. T., Kling, M. A., Chrousos, G. P., & Gold, P. W. (1989) · Brain Research · doi:10.1016/0006-8993(89)90109-1 · Cited by 87 · see citing works
Wenger, T., Jamali, K. A., Juanéda, C., Léonardelli, J., & Tramu, G. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7222 · Cited by 85 · see citing works
Lee, S., Selvage, D. J., Hansen, K. S., & RIVIER, C. L. (2004) · Endocrinology · doi:10.1210/en.2004-0110 · Cited by 82 · see citing works
Iyengar, S., Kim, H. S., & Wood, P. L. (1987) · Brain Research · doi:10.1016/0006-8993(87)91604-0 · Cited by 78 · see citing works
Levy, A. D., Li, Q., Kerr, J. E., Rittenhouse, P. A., Milonas, G., Cabrera, T. M., Battaglia, G., Sanz, M. C. A., & de Kar, L. D. V. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20273-7 · Cited by 74 · see citing works
Galici, R., Pechnick, R. N., Poland, R. E., & France, C. P. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00780-3 · Cited by 69 · see citing works
Ogilvie, K. M., Lee, S., & RIVIER, C. L. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-11-04344.1998 · Cited by 68 · see citing works
Cannabinoid CB1 receptor antagonism modulates plasma corticosterone in rodents
Wade, M. R., Degroot, A., & Nomikos, G. G. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.08.083 · Cited by 67 · see citing works
Psychostimulants and monoamine transporters: upsetting the balance
Elliott, J. M., & Beveridge, T. J. R. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.09.005 · Cited by 65 · see citing works
The action of nicotine on the pituitary-adrenal cortical axis.
Gr, C., Bassett, J. R., & Kd, C. (1979) · PubMed · Cited by 65 · see citing works
Chen, H., Fu, Y., & Sharp, B. M. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301466 · Cited by 62 · see citing works
Mantsch, J. R., Yuferov, V. P., Mathieu-Kia, A.-M., Ho, A., & Kreek, M. J. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00088-4 · Cited by 61 · see citing works
Stimulatory Effect of Cocaine on ACTH Secretion: Role of the Hypothalamus
RIVIER, C. L., & Lee, S. (1994) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1994.1021 · Cited by 61 · see citing works
Torres, G., & RIVIER, C. L. (1992) · Brain Research · doi:10.1016/0006-8993(92)90656-t · Cited by 60 · see citing works
Differential effects of response-contingent and response-independent nicotine in rats
Donny, E. C., Caggiula, A. R., Rose, C., Jacobs, K. S., Mielke, M. M., & Sved, A. F. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00532-x · Cited by 60 · see citing works
Ogilvie, K. M., Lee, S., & RIVIER, C. L. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01082-7 · Cited by 59 · see citing works
Effects of Cocaine Self-Administration on Plasma Corticosterone and Prolactin in Rats
Mantsch, J. R., Schlussman, S. D., Ho, A., & Kreek, M. J. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39062-7 · Cited by 58 · see citing works
Ježová, D., Vigas, M., & Jur̀čovičová, J. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90407-6 · Cited by 57 · see citing works
Valentine, J. D., Matta, S. G., & Sharp, B. M. (1996) · Endocrinology · doi:10.1210/endo.137.2.8593811 · Cited by 57 · see citing works
Haracz, J. L., Bloom, A. S., Wang, R. I. H., & Tseng, L. (2008) · Neuroendocrinology · doi:10.1159/000123224 · Cited by 54 · see citing works
McLaughlin, R. J., Hill, M. N., & Gorzalka, B. B. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.09.055 · Cited by 53 · see citing works
Fu, Y., Matta, S. G., Valentine, J. D., & Sharp, B. M. (1997) · Endocrinology · doi:10.1210/endo.138.5.5122 · Cited by 51 · see citing works
Siegel, R. A., Chowers, I., Conforti, N., Feldman, S., & Weidenfeld, J. (1982) · Brain Research · doi:10.1016/0006-8993(82)90174-3 · Cited by 50 · see citing works
Puder, M., Weidenfeld, J., Chowers, I., Nir, I., Conforti, N., & Siegel, R. A. (1982) · Experimental Brain Research · doi:10.1007/bf00238101 · Cited by 50 · see citing works
Zhao, R., Chen, H., & Sharp, B. M. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.112474 · Cited by 49 · see citing works
CENTRAL KAPPA- AND MU-OPIATE RECEPTORS MEDIATE ACTH-RELEASE IN RATS.
Pfeiffer, A. F. H., Herz, A., Loriaux, D. L., & Pfeiffer, D. G. (1985) · Endocrinology · doi:10.1210/endo-116-6-2688 · Cited by 49 · see citing works
Zhou, Y., Spangler, R., Maggos, C. E., Wang, X., Han, J., Ho, A., & Kreek, M. J. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1630261 · Cited by 47 · see citing works
Laorden, M. L., Castells, M. T., MartÍnez, M. D., MartÍnez, P. J., & Milanés, M. V. (2000) · Endocrinology · doi:10.1210/endo.141.4.7407 · Cited by 47 · see citing works
Spangler, R. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(96)02257-7 · Cited by 46 · see citing works
Wenger, T., Ledent, C. A., & Tramu, G. (2003) · Neuroendocrinology · doi:10.1159/000074882 · Cited by 44 · see citing works
Palamarchouk, V. S., Smagin, G. N., & Goeders, N. E. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.08.003 · Cited by 44 · see citing works
Saphier, D., Welch, J. E., Farrar, G. E., & Goeders, N. E. (2008) · Neuroendocrinology · doi:10.1159/000126342 · Cited by 43 · see citing works
Effect of ethanol on the regulation of corticotropin-releasing factor (CRF) gene expression
Li, Z., Kang, S. S., Lee, S., & RIVIER, C. L. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.04.002 · Cited by 43 · see citing works
Lolait, S. J., Stewart, L. Q., Roper, J. A., Harrison, G., Jessop, D., Young, W. S., & O’Carroll, A. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01560.x · Cited by 43 · see citing works
Further Studies on the Stimulatory Action of Nicotine on Adrenocortical Function in the Rat
Weidenfeld, J., Bodoff, M., Saphier, D., & Brenner, T. (2008) · Neuroendocrinology · doi:10.1159/000125212 · Cited by 40 · see citing works
Catecholamines Mediate Nicotine-Induced Adrenocorticotropin Secretion via a-Adrenergic Receptors*
Matta, S. G., SINGH, J., & Sharp, B. M. (1990) · Endocrinology · doi:10.1210/endo-127-4-1646 · Cited by 40 · see citing works
Roy, S., Wang, J., Balasubramanian, S., Sumandeep, S., Charboneau, R., Barke, R. A., & Loh, H. H. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00299-5 · Cited by 38 · see citing works
Acetaldehyde, a metabolite of ethanol, activates the hypothalamic-pituitary-adrenal axis in the rat
Kinoshita, H. (2001) · Alcohol and Alcoholism · doi:10.1093/alcalc/36.1.59 · Cited by 37 · see citing works
Lee, S., Smith, G. W., Vale, W., Lee, K., & RIVIER, C. L. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02231.x · Cited by 36 · see citing works
Damianopoulos, E. N., & Carey, R. J. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(94)00175-f · Cited by 35 · see citing works
Nicotinic activation of CRH neurons in extrahypothalamic regions of the rat brain
Matta, S. G., Valentine, J. D., & Sharp, B. M. (1997) · Endocrine · doi:10.1007/bf02778147 · Cited by 34 · see citing works
Ikemoto, S., & Goeders, N. E. (1998) · Brain Research · doi:10.1016/s0006-8993(98)01070-1 · Cited by 34 · see citing works
Nicotine modulation of stress‐related peptide neurons
Loughlin, S. E., Islas, M. I., Cheng, M., Lee, A. G., Villégier, A., & Leslie, F. M. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20999 · Cited by 33 · see citing works
Valentine, J. D. (1996) · Endocrinology · doi:10.1210/en.137.2.622 · Cited by 33 · see citing works
Role of the fourth cerebroventricle in mediating rat plasma ACTH responses to intravenous nicotine.
Matta, S. G., McAllen, K., & Sharp, B. M. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)19962-x · Cited by 32 · see citing works
Matta, S. G., Foster, C. A., & Sharp, B. M. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243321 · Cited by 30 · see citing works
Rotllant, D., Nadal, R. A., & Armario, A. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20345 · Cited by 30 · see citing works
Zhou, Y., Schlussman, S. D., Ho, A., Spangler, R., Fienberg, A. A., Greengard, P., & Kreek, M. J. (1999) · Neuroendocrinology · doi:10.1159/000054476 · Cited by 29 · see citing works
Extracellular Biotransformation of β‐Endorphin in Rat Striatum and Cerebrospinal Fluid
Reed, B., Bidlack, J. M., Chait, B. T., & Kreek, M. J. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01705.x · Cited by 29 · see citing works
Torres, G., RIVIER, C. L., & Weiss, F. (1994) · Brain Research · doi:10.1016/0006-8993(94)91363-3 · Cited by 28 · see citing works
Laorden, M. L. (2000) · Endocrinology · doi:10.1210/en.141.4.1366 · Cited by 28 · see citing works
Williams, M. T., Schaefer, T. L., Furay, A. R., Ehrman, L. A., & Vorhees, C. V. (2006) · Stress · doi:10.1080/10253890600902842 · Cited by 26 · see citing works
Wang, X.-Q., Imaki, T., Shibasaki, T., Yamauchi, N., & Demura, H. (1996) · Brain Research · doi:10.1016/0006-8993(95)01234-6 · Cited by 25 · see citing works
Doyle, J. R., & Yamamoto, B. K. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.10.001 · Cited by 24 · see citing works
Zhou, Y., Spangler, R., Yuferov, V. P., Schlussman, S. D., Ho, A., & Kreek, M. J. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.07.008 · Cited by 21 · see citing works
Sarnyai, Z., Bíró, É., & Telegdy, G. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90106-4 · Cited by 20 · see citing works
Endocrine effects of methadone in rats; acute effects in adults
Bartolome, M. B., & Kuhn, C. M. (1983) · European Journal of Pharmacology · doi:10.1016/0014-2999(83)90639-8 · Cited by 17 · see citing works
Okada, S., Shimizu, T., & Yokotani, K. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01966-6 · Cited by 17 · see citing works
Stimulation of ACTH release by naloxone: Central or peripheral action?
Ježová, D. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90589-2 · Cited by 12 · see citing works
Saber-Tehrani, A. S., Naderi, N., Najarkolaei, A. H., Haghparast, A., & Motamedi, F. (2009) · Neurochemical Research · doi:10.1007/s11064-009-0030-9 · Cited by 12 · see citing works
Pastor, R., Sanchis‐Segura, C., & Aragón, C. M. G. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000148107.64739.76 · Cited by 12 · see citing works
Gagliano, H., Andero, R., Armario, A., & Nadal, R. A. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1676-3 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Slominski, A. T., Zmijewski, M. A., Skobowiat, C., Zbytek, B., Slominski, R. M., & Steketee, J. D. (2012) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-19683-6 · Cited by 502 · see citing works
Slominski (2012) · doi:10.1007/978-3-642-19683-6_1 · Cited by 461 · see citing works
Key role of CRF in the skin stress response system
Slominski, A. T., Zmijewski, M. A., Zbytek, B., Tobin, D. J., Theoharides, T. C., & Rivier, J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1092 · Cited by 400 · see citing works
Nicotine and the renin-angiotensin system
Oakes, J. M., Fuchs, R. M., Gardner, J. D., Lazartigues, E. D., & Yue, X. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00099.2018 · Cited by 318 · see citing works
Induction of innate immune genes in brain create the neurobiology of addiction
Crews, F. T., Zou, J., & Qin, L. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.03.003 · Cited by 313 · see citing works
Mezuk, B., Abdou, C. M., Hudson, D., Kershaw, K. N., Rafferty, J. A., Lee, H., & Jackson, J. S. (2013) · Society and Mental Health · doi:10.1177/2156869313480892 · Cited by 231 · see citing works
The Cognition-Enhancing Effects of Psychostimulants Involve Direct Action in the Prefrontal Cortex
Spencer, R. C., Devilbiss, D. M., & Berridge, C. W. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.09.013 · Cited by 164 · see citing works
The endocannabinoid system: An emotional buffer in the modulation of memory function
Morena, M., & Campolongo, P. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.12.010 · Cited by 143 · see citing works
Autonomic, Neuroendocrine, and Immunological Effects of Ayahuasca
SANTOS, R. G. D., Valle, M., Bouso, J. C., Nomdedeu, J. F., Rodrı́guez-Espinosa, J., McIlhenny, E. H., Barker, S. A., Barbanoj, M. J., & Riba, J. (2011) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31823607f6 · Cited by 136 · see citing works
Drug-induced stress responses and addiction risk and relapse
Wemm, S. E., & Sinha, R. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100148 · Cited by 144 · see citing works
Wei, Y., & Shah, R. (2020) · Pharmaceuticals · doi:10.3390/ph13070155 · Cited by 129 · see citing works
Acute Effects of Lysergic Acid Diethylamide on Circulating Steroid Levels in Healthy Subjects
Strajhar, P., Schmid, Y., Liakoni, E., Dolder, P. C., Rentsch, K., Kratschmar, D. V., Odermatt, A., & Liechti, M. E. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12374 · Cited by 129 · see citing works
Frank, M. G., Watkins, L. R., & Maier, S. F. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.01.005 · Cited by 116 · see citing works
“Further, drugs of abuse activate the hypothalamo-pituitary–adrenal (HPA) axis (Armario, 2010).”
BackgroundStress–response pathways are altered in the hippocampus of chronic alcoholics
McClintick, J. N., Xuei, X., Tischfield, J. A., Goate, A., Foroud, T., Wetherill, L., Ehringer, M. A., & Edenberg, H. J. (2013) · Alcohol · doi:10.1016/j.alcohol.2013.07.002 · Cited by 105 · see citing works
Stress modulates illness-course of substance use disorders: a translational review
Lijffijt, M., Hu, K., & Swann, A. C. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00083 · Cited by 103 · see citing works
HPA Axis Interactions with Behavioral Systems
Packard, A. E. B., Egan, A. E., & Ulrich‐Lai, Y. M. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150042 · Cited by 130 · see citing works
Doyon, W. M., Dong, Y., Ostroumov, A., Thomas, A. M., Zhang, T. A., & Dani, J. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.006 · Cited by 104 · see citing works
Wang, S., Shao, B., Zhao, S., Chang, X., Wang, P., Miao, C., Li, Z., & Bai, Y. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1634-x · Cited by 86 · see citing works
Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells’ activity
Morel, C., Fernández, S. P., Pantouli, F., Meye, F. J., Marti, F., Tolu, S., Parnaudeau, S., Marie, H., Tronche, F., Maskos, U., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.145 · Cited by 80 · see citing works
Plaza‐Zabala, A., Flores, Á., Maldonado, R. J., & Berrendero, F. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.025 · Cited by 81 · see citing works
An Integrative Approach to HPA Axis Dysfunction: From Recognition to Recovery
Ring, M. (2025) · The American Journal of Medicine · doi:10.1016/j.amjmed.2025.05.044 · Cited by 89 · see citing works
Doyon, W. M., Thomas, A. M., Ostroumov, A., Dong, Y., & Dani, J. A. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.07.007 · Cited by 77 · see citing works
Nicotinic Regulation of Energy Homeostasis
Zoli, M., & Picciotto, M. R. (2012) · Nicotine & Tobacco Research · doi:10.1093/ntr/nts159 · Cited by 77 · see citing works
High doses of the histone deacetylase inhibitor sodium butyrate trigger a stress-like response
Gagliano, H., Delgado-Morales, R., Sanz-Garcia, A., & Armario, A. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.10.031 · Cited by 76 · see citing works
Nicotine Effects and the Endogenous Opioid System
Kishioka, S., Kiguchi, N., Kobayashi, Y., & Saika, F. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.14r03cp · Cited by 67 · see citing works
Campolongo, P., Morena, M., Scaccianoce, S., Trezza, V., Chiarotti, F., Schelling, G., Cuomo, V., & Roozendaal, B. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.26 · Cited by 68 · see citing works
Kaur, S., Li, J., Stenzel‐Poore, M. P., & Ryabinin, A. E. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01610.x · Cited by 56 · see citing works
Divergent regulation of distinct glucocorticoid systems in alcohol dependence
Edwards, S., Little, H. J., Richardson, H. N., & Vendruscolo, L. F. (2015) · Alcohol · doi:10.1016/j.alcohol.2015.04.004 · Cited by 56 · see citing works
Addiction, Adolescence, and Innate Immune Gene Induction
Crews, F. T., & Vetreno, R. P. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00019 · Cited by 52 · see citing works
Immune function genes, genetics, and the neurobiology of addiction
Crews, F. T. (2012) · Alcohol research · doi:10.35946/arcr.v34.3.11 · Cited by 52 · see citing works
Seibert, J., Hysek, C. M., Penno, C. A., Schmid, Y., Kratschmar, D. V., Liechti, M. E., & Odermatt, A. (2014) · Neuroendocrinology · doi:10.1159/000364879 · Cited by 52 · see citing works
Gene expression profiling in the human alcoholic brain
Warden, A. S., & Mayfield, R. D. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.02.017 · Cited by 51 · see citing works
Stelly, C. E., Pomrenze, M. B., Cook, J. B., & Morikawa, H. (2016) · eLife · doi:10.7554/elife.15448 · Cited by 49 · see citing works
Weinstock, J., Wadeson, H. K., & VanHeest, J. L. (2012) · Substance Abuse · doi:10.1080/08897077.2012.663327 · Cited by 47 · see citing works
Phillips, T. J., Reed, C. L., & Pastor, R. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12189 · Cited by 46 · see citing works
Cadet, J. L., Brannock, C., Ladenheim, B., McCoy, M. T., Krasnova, I. N., Lehrmann, E., Becker, K. G., & Jayanthi, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084665 · Cited by 43 · see citing works
Cook, J. B., Dumitru, A. M. G., O'Buckley, T., & Morrow, A. (2013) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.12223 · Cited by 40 · see citing works
Fischer 344 and Lewis Rat Strains as a Model of Genetic Vulnerability to Drug Addiction
Cadoni, C. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00013 · Cited by 41 · see citing works
Prenatal drug exposure and neurodevelopmental programming of glucocorticoid signalling
Franks, A. L., Berry, K. J., & DeFranco, D. B. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12786 · Cited by 39 · see citing works
Opioid modulators for alcohol dependence
Hillemacher, T., Heberlein, A., Muschler, M., Bleich, S., & Frieling, H. (2011) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2011.592139 · Cited by 41 · see citing works
Convergent Neuronal Plasticity and Metaplasticity Mechanisms of Stress, Nicotine, and Alcohol
Ostroumov, A., & Dani, J. A. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-052735 · Cited by 35 · see citing works
HPA Axis Interactions with Behavioral Systems
Packard, A. E. B., Egan, A. E., & Ulrich‐Lai, Y. M. (2016) · Comprehensive physiology · doi:10.1002/j.2040-4603.2016.tb00722.x · Cited by 35 · see citing works
Addiction: A dysregulation of satiety and inflammatory processes
Harricharan, R., Abboussi, O., & Daniels, W. M. U. (2017) · Progress in brain research · doi:10.1016/bs.pbr.2017.07.012 · Cited by 34 · see citing works
Greenwald, M. K. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.08.003 · Cited by 32 · see citing works
Drug-Induced Glucocorticoids and Memory for Substance Use
Goldfarb, E. V., & Sinha, R. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.08.005 · Cited by 29 · see citing works
Strickland, J. C., Abel, J. M., Lacy, R. T., Beckmann, J. S., Witte, M. A., Lynch, W. J., & Smith, M. A. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.04.019 · Cited by 29 · see citing works
Yamamoto, A., Kiguchi, N., Kobayashi, Y., Maeda, T., Ueno, K., Yamamoto, C., & Kishioka, S. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.10.004 · Cited by 24 · see citing works
Alterations of Stress-Related Glucocorticoids and Endocannabinoids in Hair of Chronic Cocaine Users
Voegel, C. D., Kroll, S. L., Schmid, M. W., Kexel, A.-K., Baumgartner, M. R., Kræmer, T., Binz, T. M., & Quednow, B. B. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab070 · Cited by 23 · see citing works
The Role of Physical Exercise in Opioid Substitution Therapy: Mechanisms of Sequential Effects
Psarianos, A., Chryssanthopοulos, C., Paparrigopoulos, T. J., & Philippou, Α. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054763 · Cited by 23 · see citing works
Addiction and the adrenal cortex
Vinson, G. P., & Brennan, C. H. (2013) · Endocrine Connections · doi:10.1530/ec-13-0028 · Cited by 23 · see citing works
How do stupendous cannabinoids modulate memory processing via affecting neurotransmitter systems?
Vaseghi, S., Nasehi, M., & Zarrindast, M. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.10.018 · Cited by 21 · see citing works
Moretti, S., Castelli, M., Franchi, S., Raggi, M. A., Mercolini, L., Protti, M., Somaini, L., Panerai, A. E., & Sacerdote, P. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.3hi0713-406rr · Cited by 20 · see citing works
Simone, J. J., Malivoire, B. L., & McCormick, C. M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.032 · Cited by 20 · see citing works
Nicotine-induced changes of brain β-endorphin
Gudehithlu, K. P., Duchemin, A., Tejwani, G. A., Neff, N. H., & Hadjiconstantinou, M. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.03.001 · Cited by 19 · see citing works
Combinations of oxazepam and metyrapone attenuate cocaine and methamphetamine cue reactivity
Keller, C. M., Cornett, E. M., Guerin, G. F., & Goeders, N. E. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2013.06.025 · Cited by 19 · see citing works
Zhao, S., Wu, J., He, Z., Song, Y., Chang, X., Xia, T., Xue, F., Li, Z., Xu, C., Wang, S., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00767-8 · Cited by 18 · see citing works
Ostroumov, A., Thomas, A. M., Dani, J. A., & Doyon, W. M. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.038 · Cited by 18 · see citing works
Clay, J. M., Stafford, L. D., & Parker, M. O. (2021) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-021-00599-8 · Cited by 17 · see citing works
Induction of antinociceptive tolerance to the chronic intrathecal administration of apelin-13 in rat
Abbasloo, E., Najafipour, H., & Esmaeili‐Mahani, S. (2016) · Neuropeptides · doi:10.1016/j.npep.2016.08.001 · Cited by 17 · see citing works
Amphetamines abuse and depression: Focus on TRPC channels
Fu, Y.-P., & Wang, Y. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114391 · Cited by 16 · see citing works
Rabasa, C., Pastor‐Ciurana, J., Delgado‐Morales, R., Gómez-Román, A., Carrasco, J., Gagliano, H., García‐Gutiérrez, M. S., Manzanares, J., & Armario, A. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.04.026 · Cited by 16 · see citing works
Psychiatric Symptoms, Salivary Cortisol and Cytokine Levels in Young Marijuana Users
Cloak, C. C., Alicata, D., Ernst, T. M., & Chang, L. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9606-0 · Cited by 16 · see citing works
Connor, D. A., & Gould, T. J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.07.033 · Cited by 15 · see citing works
An opponent process for alcohol addiction based on changes in endocrine gland mass
Karin, O., Raz, M., & Alon, U. S. (2021) · iScience · doi:10.1016/j.isci.2021.102127 · Cited by 17 · see citing works
Gagliano, H., Ortega-Sánchez, J. A., Nadal, R. A., & Armario, A. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4675-9 · Cited by 15 · see citing works
Inhibition of morphine tolerance is mediated by painful stimuli via central mechanisms
Iwai, S. (2012) · Drug Discoveries & Therapeutics · doi:10.5582/ddt.2012.v6.1.31 · Cited by 15 · see citing works
Cook, J. B., Nelli, S., Neighbors, M. R., Morrow, D. H., O'Buckley, T., Maldonado-Devincci, A. M., & Morrow, A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.46 · Cited by 13 · see citing works
Piza‐Palma, C., Barfield, E. T., Brown, J., Hubka, J. C., Lusk, C., Schonhar, C. D., Sweat, S. C., & Grisel, J. E. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12519 · Cited by 14 · see citing works
Effects of acute and chronic nicotine on catecholamine neurons of the nucleus of the solitary tract
Page, S. J., Zhu, M., & Appleyard, S. M. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00344.2017 · Cited by 13 · see citing works
The Reasons for Higher Mortality Rate in Opium Addicted Patients with COVID-19: A Narrative Review
Dolati‐Somarin, A., & Abd‐Nikfarjam, B. (2021) · Iranian Journal of Public Health · doi:10.18502/ijph.v50i3.5587 · Cited by 13 · see citing works
Ueno, K., Kiguchi, N., Kobayashi, Y., Saika, F., Wakida, N., Yamamoto, C., Maeda, T., Ozaki, M., & Kishioka, S. (2013) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13172fp · Cited by 11 · see citing works
Petrowski, K., & Conrad, R. (2019) · Psychopathology · doi:10.1159/000496559 · Cited by 11 · see citing works
Lu, J., Li, Q., Xu, D., Liao, Y.-B., & Wang, H. (2020) · Toxicology Letters · doi:10.1016/j.toxlet.2020.05.022 · Cited by 10 · see citing works
Manifold implications of forgotten hyperglycemia in clinical opiate dependence
Reece, A. S. (2012) · Drug and Chemical Toxicology · doi:10.3109/01480545.2011.649286 · Cited by 10 · see citing works
Dajie, G., Zhao, H., Liang, Y., Cao, R., Chen, L., Yang, S., & Yu, P. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.05.006 · Cited by 10 · see citing works
Participation of brainstem monoaminergic nuclei in behavioral depression
Lin, Y., Sarfraz, Y., Jensen, A. L., Dunn, A. J., & Stone, E. A. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.08.021 · Cited by 9 · see citing works
Lu, J., Li, Q., Ma, G., Hong, C., Zhang, W., Wang, Y., & Wang, H. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111419 · Cited by 9 · see citing works
Sampedro‐Piquero, P., Vicario, S., Pérez-Rivas, A., Venero, C., Baliyan, S., & Santín, L. J. (2020) · Brain Sciences · doi:10.3390/brainsci10100682 · Cited by 9 · see citing works
Gómez-Román, A., Ortega-Sánchez, J. A., Rotllant, D., Gagliano, H., Belda, X., Delgado‐Morales, R., Marin‐Blasco, I., Nadal, R. A., & Armario, A. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.09.006 · Cited by 9 · see citing works
Cui, B., Zhang, B.-B., Chu, C., Cui, X., & Qiu, D. (2016) · Neuroreport · doi:10.1097/wnr.0000000000000573 · Cited by 9 · see citing works
Chu, S., Yu, C., Chen, P., Hsieh, Y., & Kuo, D. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.04.025 · Cited by 8 · see citing works
Weera, M. M., Fields, M. A., Tapp, D. N., Grahame, N. J., & Chester, J. A. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13555 · Cited by 8 · see citing works
Zhang, K.-M., Zhao, G.-Y., Zhang, B.-B., Xu, Q. K., Chu, C., Jin, H., & Qiu, D. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.12.005 · Cited by 8 · see citing works
Oyola, M. G., Malysz, A. M., Mani, S. K., & Handa, R. J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802114-9.00013-5 · Cited by 7 · see citing works
Schneider, P., Goldbaum, D., Agarwal, A., Taylor, A., Sundberg, P., Gardner, E. L., Ranaldi, R., You, Z., & Galaj, E. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173931 · Cited by 5 · see citing works
Modulating reward and aversion: Insights into addiction from the paraventricular nucleus
Huang, S., Shi, C., Tao, D., Yang, C., & Luo, Y. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70046 · Cited by 5 · see citing works
Ketchesin, K. D., Becker‐Krail, D. D., Xue, X., Wilson, R. S., Lam, T. T., Williams, K. R., Nairn, A. C., Tseng, G. C., & Logan, R. W. (2023) · Journal of Proteome Research · doi:10.1021/acs.jproteome.3c00126 · Cited by 5 · see citing works
Al‐Noori, S., Cimpan, A., Maltzer, Z., Kaiyala, K. J., & Ramsay, D. S. (2017) · Stress · doi:10.1080/10253890.2017.1402175 · Cited by 5 · see citing works
Challenges to the parental brain: Neuroethological and translational considerations
Lambert, K. G., & Byrnes, E. M. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.04.004 · Cited by 5 · see citing works
Zhao, X., Hu, A., Wang, Y., Zhao, T., & Xiang, X.-J. (2024) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173726 · Cited by 4 · see citing works
Exploring the Impact of Recreational Drugs on Suicidal Behavior: A Narrative Review
Moret, R. M., Sanz‐Gómez, S., Gascón, S., & Alacreu‐Crespo, A. (2024) · Psychoactives · doi:10.3390/psychoactives3030021 · Cited by 4 · see citing works
The Neuroimmune System in Psychiatric Disorders
Hassan, Y., ESTEVES, S. C., Leyrer‐Jackson, J. M., & Thomas, M. P. (2024) · Springer eBooks · doi:10.1007/978-3-031-68237-7_56 · Cited by 3 · see citing works
Lack of effect of the combination of metyrapone and oxazepam on brain dopamine
Keller, C. M., & Goeders, N. E. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146435 · Cited by 3 · see citing works
Lu, J., Wen, Y., Zhang, L., Zhang, C., Zhong, W., Zhang, L., Yu, Y., Chen, L., Xu, D., & Wang, H. (2015) · Toxicology Research · doi:10.1039/c5tx00012b · Cited by 3 · see citing works
Keller, C. M., Breaux, K. N., & Goeders, N. E. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.12.004 · Cited by 3 · see citing works
Sunderland, G. R., Southey, B. R., Villamil, M. B., & Zas, S. L. R. (2025) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2025.104014 · Cited by 2 · see citing works
Addictive drug abuse and depression-a focus on epigenetics
Zhang, W., Xu, M., Wang, C., Liang, H., Zhu, X., Pan, Y., & Guo, F. (2026) · Communications Biology · doi:10.1038/s42003-026-09705-9 · Cited by 2 · see citing works
Zarrindast, M., & Khakpai, F. (2023) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2023-014 · Cited by 2 · see citing works
Cannabinoid pharmacology: Research on medicinal cannabins and its therapeutic application
Kulkarni, V. A., Nimje, H. P., Varhade, P. P., Chopade, R. K., Jatale, S. V., Mhaske, S. D., Nagrik, S. U., & Metangale, S. K. (2025) · Journal of Pharmaceutical and Biological Sciences · doi:10.18231/j.jpbs.2024.020 · Cited by 2 · see citing works
- Authors
- Armario, A.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Corresponding author
- Armario, Antonio
- ORCID
- Armario, Antonio
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 31
- Issue
- 7
- Pages
- 318-325
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2110450709
- Cited by
- 131
- References
- 102
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 11 · 2023: 5 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 12 · 2015: 11 · 2014: 12 · 2013: 14 · 2012: 11
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Instituto de Salud Carlos III
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- hypothalamic-pituitary-adrenal axis, drugs of abuse, drug addiction, ACTH, glucocorticoids, paraventricular nucleus, corticotropin-releasing factor, Fos expression, CRH gene expression, opioids, ethanol, cannabinoids, nicotine, cocaine, amphetamine, neuroendocrine activation
- MeSH terms
- Ethanol, Amphetamine, Analgesics, Opioid, Animals, Cannabinoids, Central Nervous System Agents, Cocaine, Humans, Hypothalamo-Hypophyseal System, Nicotine, Pituitary-Adrenal System, Treatment Outcome, Substance-Related Disorders, Metabolic Networks and Pathways
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review