The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Central nervous system effects of caffeine and adenosine on fatigue
Abstract
Caffeine ingestion can delay fatigue during exercise, but the mechanisms remain elusive. This study was designed to test the hypothesis that blockade of central nervous system (CNS) adenosine receptors may explain the beneficial effect of caffeine on fatigue. Initial experiments were done to confirm an effect of CNS caffeine and/or the adenosine A 1/A 2 receptor agonist 5′- N-ethylcarboxamidoadenosine (NECA) on spontaneous locomotor activity. Thirty minutes before measurement of spontaneous activity or treadmill running, male rats received caffeine, NECA, caffeine plus NECA, or vehicle during four sessions separated by ∼1 wk. CNS caffeine and NECA (intracerebroventricular) were associated with increased and decreased spontaneous activity, respectively, but caffeine plus NECA did not block the reduction induced by NECA. CNS caffeine also increased run time to fatigue by 60% and NECA reduced it by 68% vs. vehicle. However, unlike the effects on spontaneous activity, pretreatment with caffeine was effective in blocking the decrease in run time by NECA. No differences were found after peripheral (intraperitoneal) drug administration. Results suggest that caffeine can delay fatigue through CNS mechanisms, at least in part by blocking adenosine receptors.
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Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624
Caffeine and Exercise: Metabolism, Endurance and Performance
Graham, T. E. (2001) · Sports Medicine · doi:10.2165/00007256-200131110-00002 · Cited by 819
Metabolic, Catecholamine, and Exercise Performance Responses to Various Doses of Caffeine
Graham, T. E., & Spriet, L. L. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.78.3.867 · Cited by 488
Metabolic and exercise endurance effects of coffee and caffeine ingestion
Graham, T. E., Hibbert, E., & Sathasivam, P. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.3.883 · Cited by 305
Graham, T. E., Helge, J. W., MacLean, D. A., Kiens, B., & Richter, E. A. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00837.x · Cited by 226
Metabolic, catecholamine, and endurance responses to caffeine during intense exercise
Jackman, M., Wendling, P., Friars, D., & Graham, T. E. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.4.1658 · Cited by 207
Cited by
The Effects of Mental Fatigue on Physical Performance: A Systematic Review
Van Cutsem, J., Marcora, S., De Pauw, K., Bailey, S., Meeusen, R., & Roelands, B. (2017) · Sports Medicine · doi:10.1007/s40279-016-0672-0 · Cited by 924
A Review of Caffeine’s Effects on Cognitive, Physical and Occupational Performance
McLellan, T. M., Caldwell, J. A., & Lieberman, H. R. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.001 · Cited by 840
International society of sports nutrition position stand: caffeine and performance
Goldstein, E. R., Ziegenfuss, T., Kalman, D., Kreider, R., Campbell, B., Wilborn, C., Taylor, L., Willoughby, D., Stout, J., Graves, B. S., et al. (2010) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-7-5 · Cited by 686
International Society of Sports Nutrition Position Stand: Caffeine and Exercise Performance
Guest, N. S., VanDusseldorp, T. A., Nelson, M. T., Grgic, J., Schoenfeld, B. J., Jenkins, N. D. M., Arent, S. M., Antonio, J., Stout, J. R., Trexler, E. T., et al. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00383-4 · Cited by 665
Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance
Davis, J. M., Murphy, E. A., Carmichael, M. D., & Davis, B. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90925.2008 · Cited by 486
Self-citation
Metadata
- Authors
- Davis, J. M., Zhao, Z., Stock, H. S., Mehl, K. A., Buggy, J., & Hand, G. A.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2003-02-01
- Volume
- 284
- Issue
- 2
- Pages
- R399-R404
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2103392442
- Cited by
- 588
- References
- 6
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- closed
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