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Cited by 588

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Central nervous system effects of caffeine and adenosine on fatigue

Davis, J. Mark, Zhao, Zuowei, Stock, Howard S., Mehl, Kristen A., Buggy, James, Hand, Gregory A.·2003·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
DOI 10.1152/ajpregu.00386.2002
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Abstract

Caffeine ingestion can delay fatigue during exercise, but the mechanisms remain elusive. This study was designed to test the hypothesis that blockade of central nervous system (CNS) adenosine receptors may explain the beneficial effect of caffeine on fatigue. Initial experiments were done to confirm an effect of CNS caffeine and/or the adenosine A 1/A 2 receptor agonist 5′- N-ethylcarboxamidoadenosine (NECA) on spontaneous locomotor activity. Thirty minutes before measurement of spontaneous activity or treadmill running, male rats received caffeine, NECA, caffeine plus NECA, or vehicle during four sessions separated by ∼1 wk. CNS caffeine and NECA (intracerebroventricular) were associated with increased and decreased spontaneous activity, respectively, but caffeine plus NECA did not block the reduction induced by NECA. CNS caffeine also increased run time to fatigue by 60% and NECA reduced it by 68% vs. vehicle. However, unlike the effects on spontaneous activity, pretreatment with caffeine was effective in blocking the decrease in run time by NECA. No differences were found after peripheral (intraperitoneal) drug administration. Results suggest that caffeine can delay fatigue through CNS mechanisms, at least in part by blocking adenosine receptors.

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Metadata

Authors
Davis, J. M., Zhao, Z., Stock, H. S., Mehl, K. A., Buggy, J., & Hand, G. A.
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Published
2003-02-01
Volume
284
Issue
2
Pages
R399-R404
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
DOI
10.1152/ajpregu.00386.2002
OpenAlex
W2103392442
Cited by
588
References
6
FWCI
6.98
Type
journal article
Language
en
Open access
closed

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