The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1receptor-deficient mice
Abstract
The hypothesis that adenosine acting on adenosine A1 receptors (A1R) regulates several renal functions and mediates tubuloglomerular feedback (TGF) was examined using A1R knockout mice. We anesthetized knockout, wild-type, and heterozygous mice and measured glomerular filtration rate, TGF response using the stop-flow pressure (P(sf)) technique, and plasma renin concentration. The A1R knockout mice had an increased blood pressure compared with wild-type and heterozygote mice. Glomerular filtration rate was similar in all genotypes. Proximal tubular P(sf) was decreased from 36.7 +/- 1.2 to 25.3 +/- 1.6 mmHg in the A1R+/+ mice and from 38.1 +/- 1.0 to 27.4 +/- 1.1 mmHg in A1R+/- mice in response to an increase in tubular flow rate from 0 to 35 nl/min. This response was abolished in the homozygous A1R-/- mice (from 39.1 +/- 4.1 to 39.2 +/- 4.5 mmHg). Plasma renin activity was significantly greater in the A1R knockout mice [74.2 +/- 14.3 milli-Goldblatt units (mGU)/ml] mice compared with the wild-type and A1R+/- mice (36.3 +/- 8.5 and 34.1 +/- 9.6 mGU/ml), respectively. The results demonstrate that adenosine acting on A1R is required for TGF and modulates renin release.
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Cites
Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624 · cited 1×
“The present results are also of importance in relation to the human use of caffeine, consumed by more than 80% of the adult population in western countries (6).”
ResultSelf-citation
Cited by
International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors
Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Klotz, K.-N., & Linden, J. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01511-4 · Cited by 2,585
Self-citationAdenosine Receptors as Therapeutic Targets
Jacobson, K. A., & Gao, Z.-G. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1983 · Cited by 1,431
Renal Autoregulation in Health and Disease
Carlström, M., Wilcox, C. S., & Arendshorst, W. J. (2015) · Physiological Reviews · doi:10.1152/physrev.00042.2012 · Cited by 485
Vallon, V., Mühlbauer, B., & Osswald, H. (2006) · Physiological Reviews · doi:10.1152/physrev.00031.2005 · Cited by 448
Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance
Qi, Z., Whitt, I., Mehta, A., Jin, J., Zhao, M., Harris, R. C., Fogo, A. B., & Breyer, M. D. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00324.2003 · Cited by 331
Metadata
- Authors
- Brown, R., Ollerstam, A., Johansson, B., Skøtt, O., Gebre-Medhin, S., Fredholm, B., & Persson, A. E. G.
- Venue
- American Journal of Physiology - Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2001-09-21
- Volume
- 281
- Issue
- 5
- Pages
- R1362-R1367
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2081540360
- Cited by
- 234
- References
- 1
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brown, R., Ollerstam, A., Johansson, B., Skøtt, O., Gebre-Medhin, S., Fredholm, B., & Persson, A. E. G. (2001). Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1receptor-deficient mice. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.00470.2001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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