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Cited by 786Thermoregulation and physiological responsesIon Channels and ReceptorsThermal Regulation in Medicine

The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.

Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system

Romanovsky, Andrej A.·2007·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
DOI 10.1152/ajpregu.00668.2006
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Abstract

While summarizing the current understanding of how body temperature (T b ) is regulated, this review discusses the recent progress in the following areas: central and peripheral thermosensitivity and temperature-activated transient receptor potential (TRP) channels; afferent neuronal pathways from peripheral thermosensors; and efferent thermoeffector pathways. It is proposed that activation of temperature-sensitive TRP channels is a mechanism of peripheral thermosensitivity. Special attention is paid to the functional architecture of the thermoregulatory system. The notion that deep T b is regulated by a unified system with a single controller is rejected. It is proposed that T b is regulated by independent thermoeffector loops, each having its own afferent and efferent branches. The activity of each thermoeffector is triggered by a unique combination of shell and core T b s. Temperature-dependent phase transitions in thermosensory neurons cause sequential activation of all neurons of the corresponding thermoeffector loop and eventually a thermoeffector response. No computation of an integrated T b or its comparison with an obvious or hidden set point of a unified system is necessary. Coordination between thermoeffectors is achieved through their common controlled variable, T b . The described model incorporates Kobayashi’s views, but Kobayashi’s proposal to eliminate the term sensor is rejected. A case against the term set point is also made. Because this term is historically associated with a unified control system, it is more misleading than informative. The term balance point is proposed to designate the regulated level of T b and to attract attention to the multiple feedback, feedforward, and open-loop components that contribute to thermal balance.

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Crossref · 10.1152/ajpregu.00668.2006

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Metadata

Authors
Romanovsky, A. A.
Affiliations
St. Joseph's Hospital and Medical Center (US)
Corresponding author
Romanovsky, Andrej A.
ORCID
Romanovsky, Andrej A.
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Published
2007-01
Volume
292
Issue
1
Pages
R37-R46
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
DOI
10.1152/ajpregu.00668.2006
OpenAlex
W2105155111
Semantic Scholar
951d6465df2e12dece490320600c7edb60b61d1b
Cited by
786
References
140
Citations by year
2026: 25 · 2025: 36 · 2024: 38 · 2023: 62 · 2022: 31 · 2021: 45 · 2020: 27 · 2019: 37 · 2018: 45 · 2017: 43 · 2016: 48 · 2015: 53 · 2014: 52 · 2013: 44 · 2012: 42
FWCI
2.87
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS041233, NS41233)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
Keywords
thermoregulation, thermosensitive TRP channels, set point, balance point, thermosensory neurons, open-loop control
MeSH terms
Afferent Pathways, Animals, Autonomic Nervous System, Body Temperature Regulation, Humans, Neurons, Afferent, Peripheral Nervous System, Transient Receptor Potential Channels

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