Cited by 197Cardiovascular and exercise physiologyPhysical Activity and HealthCircadian rhythm and melatonin

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Novel quantitative phenotypes of exercise training in mouse models

De Bono, J. P., Adlam, D., Paterson, D. J., Channon, K. M.·2006·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.00694.2005

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Abstract

Regular physical exercise has beneficial effects in many human disease states, including cardiovascular diseases, cancer, and depression. Exercise training of genetically modified mouse models may provide insight into the molecular mechanisms that underlie the beneficial effects of exercise. Presently, there is relatively little understanding of the normal physiology of mouse exercise. In this paper, we describe a novel computerized voluntary wheel-running system capable of recording and analyzing individual wheel rotations. Using this system, we demonstrate that C57BL/6 mice run considerable distances during the night in short bouts and at a preferred speed: the cruising speed. We find that the vast majority of running occurs around this cruising speed, which is close to the maximum speed at which the animal can run but is significantly higher than the average speeds recorded by simple digital odometers. We describe how these parameters vary with exercise training and demonstrate marked sex differences in the patterns of voluntary exercise. The results of this study have important implications for the design and interpretation of both voluntary and forced exercise experiments in mouse models. The novel parameters described provide more physiological quantitative measures of voluntary exercise activity and training and will extend the physiological utility of exercise training as a phenotyping tool in genetic mouse models.

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Authors: De Bono, J. P., Adlam, D., Paterson, D. J., & Channon, K. M.
ORCID: Adlam, D.
Paterson, D. J.
Channon, K. M.
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 2006-04
Volume: 290
Issue: 4
Pages: R926-R934
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.00694.2005
OpenAlex: W2102072551
Cited by: 197
References: 29
Citations by year: 2026: 10 · 2025: 17 · 2024: 8 · 2023: 11 · 2022: 12 · 2021: 11 · 2020: 11 · 2019: 4 · 2018: 7 · 2017: 11 · 2016: 7 · 2015: 13 · 2014: 13 · 2013: 13 · 2012: 7
FWCI: 10.56
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
PubMed (publishedVersion)
Leicester Research Archive (University of Leicester) (submittedVersion)
Web Science
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: voluntary wheel running, exercise training, cruising speed, running distance, sex differences in exercise, C57BL/6 mice, genetic mouse models
MeSH terms: Animals, Body Weight, Circadian Rhythm, Computers, Female, Cardiomegaly, Humans, Male, Mice, Inbred C57BL, Monitoring, Physiologic, Phenotype, Running, Sex Characteristics, Exercise, Models, Animal, Mice

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Novel quantitative phenotypes of exercise training in mouse models

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