The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Novel quantitative phenotypes of exercise training in mouse models
Abstract
Regular physical exercise has beneficial effects in many human disease states, including cardiovascular diseases, cancer, and depression. Exercise training of genetically modified mouse models may provide insight into the molecular mechanisms that underlie the beneficial effects of exercise. Presently, there is relatively little understanding of the normal physiology of mouse exercise. In this paper, we describe a novel computerized voluntary wheel-running system capable of recording and analyzing individual wheel rotations. Using this system, we demonstrate that C57BL/6 mice run considerable distances during the night in short bouts and at a preferred speed: the cruising speed. We find that the vast majority of running occurs around this cruising speed, which is close to the maximum speed at which the animal can run but is significantly higher than the average speeds recorded by simple digital odometers. We describe how these parameters vary with exercise training and demonstrate marked sex differences in the patterns of voluntary exercise. The results of this study have important implications for the design and interpretation of both voluntary and forced exercise experiments in mouse models. The novel parameters described provide more physiological quantitative measures of voluntary exercise activity and training and will extend the physiological utility of exercise training as a phenotyping tool in genetic mouse models.
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“Additionally, previous studies have revealed that female rodents show higher endurance capacities and anti-fatigue properties than male rodents (107, 108).”
From From mitochondria to sarcopenia: role of 17β-estradiol and testosterone (2023) · cites this paper as [107]
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Cites
Measuring agreement in method comparison studies
Bland, J. M., & Altman, D. G. (1999) · Statistical Methods in Medical Research · doi:10.1177/096228029900800204 · Cited by 9,619
Taylor, R. S., Brown, A., Ebrahim, S., Jolliffe, J., Noorani, H., Rees, K., Skidmore, B., Stone, J. A., Thompson, D. R., & Oldridge, N. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.01.009 · Cited by 2,239
Effects of exercise training on older patients with major depression
Blumenthal, J. A., Babyak, M. A., Moore, K. A., Craighead, W. E., Herman, S., Khatri, P., Waugh, R., Napolitano, M. A., Forman, L. M., Appelbaum, M., et al. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.19.2349 · Cited by 1,277
Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH)
Piepoli, M. F., Davos, C. H., Francis, D. P., & Coats, A. J. S. (2004) · BMJ · doi:10.1136/bmj.37938.645220.ee · Cited by 994
Exercise-based rehabilitation for coronary heart disease
Jolliffe, J., Rees, K., Taylor, R. R., Thompson, D. R., Oldridge, N., & Ebrahim, S. (2001) · The Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001800 · Cited by 963
Exercise Type and Intensity in Relation to Coronary Heart Disease in Men
Tanasescu, M. (2002) · JAMA · doi:10.1001/jama.288.16.1994 · Cited by 928
Laufs, U., Werner, N., Link, A., Endres, M., Waßmann, S., Jürgens, K., Miche, E., Böhm, M., & Nickenig, G. (2003) · Circulation · doi:10.1161/01.cir.0000109141.48980.37 · Cited by 858
Exercise training in patients with chronic heart failure: Fig 1: Authors' reply
Piepoli, M. F., & Francis, D. P. (2004) · BMJ · doi:10.1136/bmj.328.7441.711-b · Cited by 472
Artificial Selection for Increased Wheel-Running Behavior in House Mice
Swallow, J. G., Carter, P. A., & Garland, T. (1998) · Behavior Genetics · doi:10.1023/a:1021479331779 · Cited by 389
Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse
Allen, D. L., Harrison, B. C., Maass, A. H., Bell, M., Byrnes, W. C., & Leinwand, L. A. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.5.1900 · Cited by 377
Lerman, I. R., Harrison, B. C., Freeman, K., Hewett, T. E., Allen, D. L., Robbins, J. M., & Leinwand, L. A. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01045.2001 · Cited by 272
KEMMLER, W. K., Lauber, D., Weineck, J., Hensen, J., Kalender, W. A., & Engelke, K. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.10.1084 · Cited by 247
Sex modifies exercise and cardiac adaptation in mice
Konhilas, J. P., Maass, A. H., Luckey, S. W., Stauffer, B. L., Olson, E. N., & Leinwand, L. A. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00292.2004 · Cited by 206
Behaviour of house mice artificially selected for high levels of voluntary wheel running
Koteja, P., Garland, T., Sax, J. K., Swallow, J. G., & Carter, P. A. (1999) · Animal Behaviour · doi:10.1006/anbe.1999.1270 · Cited by 144
Kojda, G., Cheng, Y. C., Burchfield, J. S., & Harrison, D. G. (2001) · Circulation · doi:10.1161/01.cir.103.23.2839 · Cited by 143
Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training
Davis, M. E., Cai, H. “., McCann, L. A., Fukai, T., & Harrison, D. G. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00918.2002 · Cited by 119
Girard, I., McAleer, M. W., Rhodes, J. S., & Garland, T. (2001) · Journal of Experimental Biology · doi:10.1242/jeb.204.24.4311 · Cited by 107
Strain-dependent differences in responses to exercise training in inbred and hybrid mice
Massett, M. P., & Berk, B. C. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00476.2004 · Cited by 106
Lauer, N., Suvorava, T., Rüther, U., JACOB, R., MEYER, W., Harrison, D. G., & Kojda, G. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.09.010 · Cited by 95
Influence of genetic background on daily running-wheel activity differs with aging
Turner, M. J., Kleeberger, S. R., & Lightfoot, J. T. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00243.2004 · Cited by 93
Swallow, J. G. (2005) · Integrative and Comparative Biology · doi:10.1093/icb/45.3.426 · Cited by 80
Habitual exercise program protects murine intestinal, skeletal, and cardiac muscles against aging
Rosa, E. F., Silva, A. C., Ihara, S. S. M., Mora, O. A., Aboulafia, J., & Nouailhetas, V. L. A. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00417.2005 · Cited by 77
Exercise assessment of transgenic models of human cardiovascular disease
Bernstein, D. J. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00188.2002 · Cited by 77
Limited Exercise Capacity in Heterozygous Manganese Superoxide Dismutase Gene–Knockout Mice
Kinugawa, S., Wang, Z., Kaminski, P. M., Wolin, M. S., Edwards, J. G., Kaley, G., & Hintze, T. H. (2005) · Circulation · doi:10.1161/01.cir.0000159261.11520.63 · Cited by 60
Effects of voluntary wheel running and amino acid supplementation on skeletal muscle of mice
Pellegrino, M. A., Brocca, L., Dioguardi, F. S., Bottinelli, R., & D’Antona, G. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-004-1237-8 · Cited by 56
Lapveteläinen, T., Tiihonen, A., Koskela, P., Nevalainen, T. O., Lindblom, J., Kiraly, K., Halonen, P., & Helminen, H. J. (1997) · PubMed · Cited by 40
Physical exercise, use of Plantago ovata and aspirin, and reduced risk of colon cancer
Juarranz, M., Calle-Purón, M.-E., González-Navarro, A., Regidor, E., Soriano, T., Hernández, D. M., Rojas, V.-D., & Guinee, V. F. (2002) · European Journal of Cancer Prevention · doi:10.1097/00008469-200210000-00009 · Cited by 35
Bins, bouts and wheel-running speed
Eikelboom, R. (2001) · Animal Behaviour · doi:10.1006/anbe.2000.1607 · Cited by 16
Low intensity exercise in healthy-weight women reduces risk of breast cancer
Rintala, P. E. (2004) · Evidence-based Healthcare · doi:10.1016/j.ehbc.2004.02.012 · Cited by 2
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Metadata
- Authors
- De Bono, J. P., Adlam, D., Paterson, D. J., & Channon, K. M.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2006-04
- Volume
- 290
- Issue
- 4
- Pages
- R926-R934
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2102072551
- Cited by
- 197
- References
- 29
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 8 · 2023: 11 · 2022: 12 · 2021: 11 · 2020: 11 · 2019: 4 · 2018: 7 · 2017: 11 · 2016: 7 · 2015: 13 · 2014: 13 · 2013: 13 · 2012: 7
- FWCI
- 10.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Web Science
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- voluntary wheel running, exercise training, cruising speed, running distance, sex differences in exercise, C57BL/6 mice, genetic mouse models
- MeSH terms
- Animals, Body Weight, Circadian Rhythm, Computers, Female, Cardiomegaly, Humans, Male, Mice, Inbred C57BL, Monitoring, Physiologic, Phenotype, Running, Sex Characteristics, Exercise, Models, Animal, Mice
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