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Importance of lipolysis in oral cavity for orosensory detection of fat
Abstract
Lingual lipase is usually secreted from von Ebner's glands, although there is great variation between species. Lingual lipase is thought to be an auxiliary enzyme for fat digestion and absorption in mammals; however, the reason for lipolysis in the oral cavity is not known. We focused on the gustatory sense and investigated the significance of lingual lipase in the perception of a fat taste by using orlistat, a potent lipase inhibitor. Five-minute two-bottle preference tests demonstrated that the addition of orlistat diminished the preference for triacylglycerides but not for free fatty acids. Radioactive triolein applied on rats' circumvallate papilla revealed that lingual lipase was released continuously to generate significant amounts of fatty acids and other lipolytic products within 1–5 s, which was enough time to taste fat. These findings suggest that lingual lipase is released to perceive the taste of triacylglycerides and to find nutritive lipids in food.
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Citations
Cited by
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Abumrad, N. A., & Davidson, N. O. (2012) · Physiological Reviews · doi:10.1152/physrev.00019.2011 · Cited by 355
The neural mechanisms of gustation: A distributed processing code
Simon, S. A., de Araujo, I. E., Gutierrez, R., & Nicolelis, M. A. L. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2006 · Cited by 305
Sham feeding corn oil increases accumbens dopamine in the rat
Liang, N.-C., Hajnal, A., & Norgren, R. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00226.2006 · Cited by 179
The macronutrients, appetite, and energy intake
Carreiro, A. L., Dhillon, J., Gordon, S., Higgins, K. A., Jacobs, A. G., McArthur, B. M., Redan, B. W., Rivera, R. L., Schmidt, L. R., & Mattes, R. D. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-121415-112624 · Cited by 159
Oro-sensory perception of dietary lipids: new insights into the fat taste transduction
Khan, N. A., & Besnard, P. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.01.001 · Cited by 111
Metadata
- Authors
- Kawai, T., & Fushiki, T.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2003-08
- Volume
- 285
- Issue
- 2
- Pages
- R447-R454
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2034768007
- Cited by
- 224
- References
- 0
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kawai, T., & Fushiki, T. (2003). Importance of lipolysis in oral cavity for orosensory detection of fat. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.00729.2002
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