Sham feeding corn oil increases accumbens dopamine in the rat
Abstract
Both real and sham feeding of sucrose increase dopamine (DA) overflow in the nucleus accumbens (NAc). Fat is another constituent of foods that is inherently preferred by humans and rodents. We examined the affect of sham feeding corn oil in rats that were food and water deprived overnight. Rats were implanted with guide cannulas aimed at the NAc, as well as gastric fistulas. On alternate days, they were trained to sham lick 100% corn oil or distilled water (dH 2 O) for 20 min in the morning. Twenty-minute microdialysis samples were taken before, during, and after sham licking. DA and monoamines were analyzed by reverse-phase HPLC with coulometric detection. The results show that DA release in the NAc was significantly increased during sham licking of corn oil compared with the prior baseline (157.5 ± 18.8%, n = 12). During sham licking of dH 2 O, DA release in the NAc was not changed (93.0 ± 4.0%, n = 15). This experiment demonstrates that sham feeding of corn oil releases accumbens DA in a manner similar to ingestion of sucrose. Although both stimuli may have an olfactory component, sucrose is a gustatory, and 100% corn oil appears to be a trigeminal stimulus. Thus these data support the hypothesis that different sensory modalities produce reward using the same or closely related substrates in the forebrain.
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For nonsweet palatable foods (typically high-fat foods), there is less convincing evidence for development of dependence, although intermittent access to corn oil can stimulate dopamine release in the nucleus accumbens.
“For nonsweet palatable foods (typically high-fat foods), there is less convincing evidence for development of dependence ([21](#B21), [31](#B31)), although intermittent access to corn oil can stimulate dopamine release in the nucleus accumbens ([106](#B106)).”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [106]
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- Authors
- Liang, N.-C., Hajnal, A., & Norgren, R.
- Affiliations
- Pennsylvania State University (US)
- ORCID
- Liang, Nu-Chu
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2006-11
- Volume
- 291
- Issue
- 5
- Pages
- R1236-R1239
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2159508473
- Cited by
- 179
- References
- 35
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 1 · 2022: 3 · 2021: 8 · 2020: 6 · 2019: 4 · 2018: 13 · 2017: 7 · 2016: 12 · 2015: 18 · 2014: 15 · 2013: 10 · 2012: 18
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- bioMérieux
- Centers for Disease Control and Prevention
- National Institute on Deafness and Other Communication Disorders (DC 05435, DC 00240, R01DC000240, R01DC005435)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK065709, R01DK065709)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- sham feeding, corn oil, nucleus accumbens, dopamine release, reward, food deprivation, sucrose, olfactory cues, gustatory cues, monoamines, microdialysis, gastric fistula
- MeSH terms
- Animals, Corn Oil, Dopamine, Feeding Behavior, Male, Memory, Neurons, Afferent, Nucleus Accumbens, Reward, Taste, Rats, Sprague-Dawley, Rats
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