Role of PGC-1α in exercise and fasting-induced adaptations in mouse liver
Abstract
The transcriptional coactivator peroxisome proliferator-activated receptor (PPAR)-γ coactivator (PGC)-1α plays a role in regulation of several metabolic pathways. By use of whole body PGC-1α knockout (KO) mice, we investigated the role of PGC-1α in fasting, acute exercise and exercise training-induced regulation of key proteins in gluconeogenesis and metabolism in the liver. In both wild-type (WT) and PGC-1α KO mice liver, the mRNA content of the gluconeogenic proteins glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) was upregulated during fasting. Pyruvate carboxylase (PC) remained unchanged after fasting in WT mice, but it was upregulated in PGC-1α KO mice. In response to a single exercise bout, G6Pase mRNA was upregulated in both genotypes, whereas no significant changes were detected in PEPCK or PC mRNA. While G6Pase and PC protein remained unchanged, liver PEPCK protein content was higher in trained than untrained mice of both genotypes. The mRNA content of the mitochondrial proteins cytochrome c (Cyt c) and cytochrome oxidase (COX) subunit I was unchanged in response to fasting. The mRNA and protein content of Cyt c and COXI increased in the liver in response to a single exercise bout and prolonged exercise training, respectively, in WT mice, but not in PGC-1α KO mice. Neither fasting nor exercise affected the mRNA expression of antioxidant enzymes in the liver, and knockout of PGC-1α had no effect. In conclusion, these results suggest that PGC-1α plays a pivotal role in regulation of Cyt c and COXI expression in the liver in response to a single exercise bout and prolonged exercise training, which implies that exercise training-induced improvements in oxidative capacity of the liver is regulated by PGC-1α.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In mice, PGC1α is required for an exercise-induced increase in mitochondrial volume density and reduction in intrahepatic lipid content.
“In mice, PGC1α is required for an exercise-induced increase in mitochondrial volume density and reduction in intrahepatic lipid content (231).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [231]
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491 · see citing works
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
Yoon, J. C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Stafford, J., Kahn, C. R., Granner, D. K., et al. (2001) · Nature · doi:10.1038/35093050 · Cited by 1,821 · see citing works
Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
Puigserver, P., Rhee, J., Donovan, J., Walkey, C. J., Yoon, J. C., Oriente, F., Kitamura, Y., Altomonte, J., Dong, H., Accili, D., et al. (2003) · Nature · doi:10.1038/nature01667 · Cited by 1,487 · see citing works
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
Herzig, S., Long, F., Jhala, U. S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P., et al. (2001) · Nature · doi:10.1038/35093131 · Cited by 1,440 · see citing works
Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice
Lin, J., Wu, P.-H., Tarr, P. T., Lindenberg, K. S., St-Pierre, J., Zhang, C.-Y., Mootha, V. K., Jäger, S., Vianna, C. R., Reznick, R. M., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.013 · Cited by 1,162 · see citing works
Leone, T. C., Lehman, J. J., Finck, B. N., Schaeffer, P. J., Wende, A. R., Boudina, S., Courtois, M., Wozniak, D. F., Sambandam, N., Bernal-Mizrachi, C., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030101 · Cited by 951 · see citing works
Handschin, C., Chin, S., Li, P., Liu, F., Maratos-Flier, E., LeBrasseur, N. K., Yan, Z., & Spiegelman, B. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704817200 · Cited by 611 · see citing works
Rhee, J., Inoue, Y., Yoon, J. C., Puigserver, P., Fan, M., Gonzalez, F. J., & Spiegelman, B. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730870100 · Cited by 564 · see citing works
Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise
Pilegaard, H., Ordway, G. A., Saltin, B., & Neufer, P. D. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.4.e806 · Cited by 563 · see citing works
Self-citationNutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α
Handschin, C., Lin, J. D., Rhee, J., Peyer, A., Chin, S., Wu, P., Meyer, U., & Spiegelman, B. M. (2005) · Cell · doi:10.1016/j.cell.2005.06.040 · Cited by 380 · see citing works
Calvo, J. A., Daniels, T. G., Wang, X., Paul, A., Lin, J., Spiegelman, B. M., Stevenson, S. C., & Rangwala, S. M. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01231.2007 · Cited by 377 · see citing works
Wende, A. R., Huss, J. M., Schaeffer, P. J., Giguère, V., & Kelly, D. P. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.10684-10694.2005 · Cited by 354 · see citing works
Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-α
Puigserver, P. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802905 · Cited by 290 · see citing works
AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise.
Kelly, M., Keller, C., Avilucea, P. R., Keller, P., Luo, Z., Xiang, X., Giralt, M., Hidalgo, J., Saha, A. K., Pedersen, B. K., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.188 · Cited by 289 · see citing works
Self-citationA role for the transcriptional coactivator PGC-1α in muscle refueling.
Wende, A. R., Schaeffer, P. J., Parker, G. J., Zechner, C., Han, D.-H., Chen, M. M., Hancock, C. R., Lehman, J. J., Huss, J. M., McClain, D. A., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707006200 · Cited by 257 · see citing works
PGC-1 coactivators and skeletal muscle adaptations in health and disease
Arany, Z. P. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.07.018 · Cited by 244 · see citing works
Leick, L., Wojtaszewski, J. F. P., Johansen, S. T., Kiilerich, K., Comes, G., Hellsten, Y., Hidalgo, J., & Pilegaard, H. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00666.2007 · Cited by 236 · see citing works
Self-citationCimbala, M. A., Lamers, W. H., Nelson, K., Monahan, J. E., Yoo-Warren, H., & Hanson, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34426-0 · Cited by 198 · see citing works
Lundby, C., Nordsborg, N. B., Kusuhara, K., Kristensen, K. M., Neufer, P. D., & Pilegaard, H. (2005) · European Journal of Applied Physiology · doi:10.1007/s00421-005-0022-7 · Cited by 173 · see citing works
Self-citationAn enzymic method for measurement of glycogen
Passonneau, J. V., Gatfield, P. D., Schulz, D. W., & Lowry, O. H. (1967) · Analytical Biochemistry · doi:10.1016/0003-2697(67)90167-4 · Cited by 165 · see citing works
Pilegaard, H., Saltin, B., & Neufer, P. D. (2003) · Diabetes · doi:10.2337/diabetes.52.3.657 · Cited by 157 · see citing works
Self-citationSystemic and mitochondrial adaptive responses to moderate exercise in rodents
Boveris, A., & Navarro, A. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.08.015 · Cited by 151 · see citing works
Estall, J. L., Kahn, M., Cooper, M. P., Fisher, F. M., Wu, M. K., Laznik, D., Qu, L., Cohen, D. E., Shulman, G. I., & Spiegelman, B. M. (2009) · Diabetes · doi:10.2337/db08-1571 · Cited by 148 · see citing works
Molecular and cellular adaptation of muscle in response to physical training
Booth, F. W., Tseng, B. S., Flück, M., & Carson, J. A. (1998) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1998.0326e.x · Cited by 121 · see citing works
Leick, L., Lyngby, S. S., Wojtaszewski, J. F. P., & Pilegaard, H. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.011 · Cited by 116 · see citing works
Self-citationHildebrandt, A. L., Pilegaard, H., & Neufer, P. D. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00234.2003 · Cited by 107 · see citing works
Self-citationBurneiko, R. C., Diniz, Y. S., Galhardi, C. M., Rodrigues, H. G., Ebaid, G. M. X., Faine, L. A., Padovani, C. R., Cicogna, A. C., & Novelli, E. L. B. (2006) · Food and Chemical Toxicology · doi:10.1016/j.fct.2006.01.004 · Cited by 104 · see citing works
Hoene, M., Lehmann, R., Hennige, A. M., Pohl, A. K., Häring, H. U., Schleicher, E. D., & Weigert, C. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.160275 · Cited by 92 · see citing works
Exercise modulates antioxidant enzyme gene expression in rat myocardium and liver
Wilson, D., & Johnson, P. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.5.1791 · Cited by 71 · see citing works
The Coactivator SRC-1 Is an Essential Coordinator of Hepatic Glucose Production
Louet, J., Chopra, A. R., Sagen, J. V., An, J., York, B., Tannour‐Louet, M., Saha, P., Stevens, R. D., Wenner, B. R., Ilkayeva, O., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.009 · Cited by 69 · see citing works
Endurance training alters antioxidant enzyme gene expression in rat skeletal muscle
Gore, M. T., Fiebig, R., Hollander, J. M., Leeuwenburgh, C., Ohno, H., & Ji, L. L. (1998) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y98-125 · Cited by 64 · see citing works
Metabolic control of hepatic gluconeogenesis during exercise
Dohm, G. L., & Newsholme, E. A. (1983) · Biochemical Journal · doi:10.1042/bj2120633 · Cited by 48 · see citing works
Banzet, S., Koulmann, N., Simler, N., Sanchez, H., Chapot, R., Serrurier, B., Peinnequin, A., & Bigard, X. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00739.2009 · Cited by 42 · see citing works
Time course of changes in gluconeogenic enzyme activities during exercise and recovery
Dohm, G. L., Kasperek, G. J., & Barakat, H. A. (1985) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1985.249.1.e6 · Cited by 40 · see citing works
Effect of different models of physical exercise on oxidative stress markers in mouse liver
da Silva, L. A., Pinho, C. A., Rocha, L. G., Tuon, T., Silveira, P. C. L., & Pinho, R. A. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-132 · Cited by 40 · see citing works
Increased density of glucagon receptors in liver from endurance-trained rats
Légaré, A., Drouin, R., Milot, M., Massicotte, D., Péronnet, F., Massicotte, G., & Lavoie, C. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.1.e193 · Cited by 26 · see citing works
Effect of exercise on hepatic gene expression in rats: a microarray analysis
Aoi, W., Ichiishi, E., Sakamoto, N., Tsujimoto, A., Tokuda, H., & Yoshikawa, T. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.04.053 · Cited by 24 · see citing works
Metabolic Responses to Prolonged Fasting and Subsequent Refeeding in the Pig
Klain, G. J., Sullivan, F. J., Chinn, K. S. K., Hannon, J. P., & Jones, L. D. (1977) · Journal of Nutrition · doi:10.1093/jn/107.3.426 · Cited by 22 · see citing works
Drouin, R., Robert, G., Milot, M., Massicotte, D., Péronnet, F., & Lavoie, C. (2004) · Metabolism · doi:10.1016/j.metabol.2004.03.010 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Role of ROS and RNS Sources in Physiological and Pathological Conditions
Meo, S. D., Reed, T. T., Venditti, P., & Víctor, V. M. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1245049 · Cited by 1,638 · see citing works
Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease
Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00211 · Cited by 787 · see citing works
PGC-1α as a Pivotal Factor in Lipid and Metabolic Regulation
Cheng, C., Ku, H., & Lin, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113447 · Cited by 434 · see citing works
Exercise and the Regulation of Hepatic Metabolism
Trefts, E., Williams, A. S., & Wasserman, D. H. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.07.010 · Cited by 194 · see citing works
Morris, E. M., Meers, G. M.-E., Booth, F. W., Fritsche, K. L., Hardin, C. D., Thyfault, J. P., & Ibdah, J. A. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00169.2012 · Cited by 186 · see citing works
Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice
Gusdon, A. M., Callio, J., Distéfano, G., O'Doherty, R. M., Goodpaster, B. H., Coen, P. M., & Chu, C. T. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.01.013 · Cited by 109 · see citing works
Effects of exercise training on intrahepatic lipid content in humans
Brouwers, B., Hesselink, M. K. C., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2016) · Diabetologia · doi:10.1007/s00125-016-4037-x · Cited by 94 · see citing works
Mitochondrial Dysfunction in the Transition from NASH to HCC
Léveillé, M., & Estall, J. L. (2019) · Metabolites · doi:10.3390/metabo9100233 · Cited by 93 · see citing works
Effects of physical activity upon the liver
Shephard, R. J., & Johnson, N. A. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-3031-6 · Cited by 88 · see citing works
Metformin affects the circadian clock and metabolic rhythms in a tissue-specific manner
Barnea, M., Haviv, L., Gutman, R., Chapnik, N., Madar, Z., & Froy, O. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.08.005 · Cited by 86 · see citing works
Impact of Various Exercise Modalities on Hepatic Mitochondrial Function
Fletcher, J. A., Meers, G. M.-E., Linden, M. A., Kearney, M. L., Morris, E. M., Thyfault, J. P., & Rector, R. S. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000223 · Cited by 69 · see citing works
Zhang, Y., Uguccioni, G., Ljubicic, V., Irrcher, I., Iqbal, S., Singh, K., Ding, S., & Hood, D. A. (2014) · Physiological Reports · doi:10.14814/phy2.12008 · Cited by 68 · see citing works
Exercise modulates liver cellular and mitochondrial proteins related to quality control signaling
Alves, E. S., Marques‐Aleixo, I., Rizo‐Roca, D., Torrella, J. R., Oliveira, P. J., Magalhães, J., & Ascensão, A. A. M. R. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.06.007 · Cited by 65 · see citing works
Oxidative stress and inflammation: liver responses and adaptations to acute and regular exercise
Barcelos, R. P., Royes, L. F. F., González‐Gallego, J., & Bresciani, G. (2017) · Free Radical Research · doi:10.1080/10715762.2017.1291942 · Cited by 65 · see citing works
Intermittent fasting influences immunity and metabolism
Marko, D. M., Conn, M. O., & Schertzer, J. D. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.04.014 · Cited by 62 · see citing works
Moreno-Arriola, E., Hafidi, M. E., Ortega-Cuéllar, D., & Carvajal, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148089 · Cited by 55 · see citing works
Roberts, F. L., & Markby, G. R. (2021) · Cells · doi:10.3390/cells10102639 · Cited by 53 · see citing works
Peppler, W. T., Townsend, L. K., Knuth, C. M., Foster, M. T., & Wright, D. C. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00226.2017 · Cited by 52 · see citing works
Morris, E. M., Jackman, M. R., Meers, G. M.-E., Johnson, G. C., Lopez, J. L., MacLean, P. S., & Thyfault, J. P. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00179.2013 · Cited by 48 · see citing works
Jani, S., Eira, D. D., Stefanovic, M., & Ceddia, R. B. (2022) · The Journal of Physiology · doi:10.1113/jp283552 · Cited by 47 · see citing works
Gaspar, R. C., Veiga, C. B., Pereira, M. B., Dátilo, M. N., Sant’Ana, M. R., Rodrigues, P. B., de Moura, L. P., da Silva, A. S. R., dos Santos, G. A., Catharino, R. R., et al. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.12.003 · Cited by 45 · see citing works
Knudsen, J. G., Gudiksen, A., Bertholdt, L., Overby, P., Villesen, I., Schwartz, C. L., & Pilegaard, H. (2017) · PLOS ONE · doi:10.1371/journal.pone.0189301 · Cited by 42 · see citing works
Self-citationda Rocha, A. L., Pereira, B. C., Pauli, J. R., Cintra, D. E., de Souza, C. T., Ropelle, E. R., & da Silva, A. S. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140020 · Cited by 42 · see citing works
Voluntary wheel running attenuates lipopolysaccharide-induced liver inflammation in mice
Peppler, W. T., Anderson, Z. G., Sutton, C. D., Rector, R. S., & Wright, D. C. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00497.2015 · Cited by 33 · see citing works
Acute responses of circulating microRNAs to low-volume sprint interval cycling
Cui, S. F., Li, W., Niu, J., Zhang, C. Y., Chen, X., & Zheng, J. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00311 · Cited by 31 · see citing works
Khoo, W. Y. H., Chrisfield, B. J., Sae‐tan, S., & Lambert, J. D. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.108262 · Cited by 31 · see citing works
Fuller, S. E., Huang, T., Simon, J., Batdorf, H. M., Essajee, N. M., Scott, M. C., Waskom, C., Brown, J. M., Burke, S. J., Collier, J. J., et al. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00820.2018 · Cited by 30 · see citing works
Fibroblast growth factor 21 and exercise-induced hepatic mitochondrial adaptations
Fletcher, J. A., Linden, M. A., Sheldon, R. D., Meers, G. M.-E., Morris, E. M., Butterfield, A. M., Perfield, J. W., Thyfault, J. P., & Rector, R. S. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00355.2015 · Cited by 28 · see citing works
Exercise-induced regulation of key factors in substrate choice and gluconeogenesis in mouse liver
Knudsen, J. G., Biensø, R. S., Hassing, H. A., Jakobsen, A. H., & Pilegaard, H. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2351-0 · Cited by 28 · see citing works
Self-citationPaoli, A. (2025) · Nutrients · doi:10.3390/nu17040663 · Cited by 26 · see citing works
Beneficial effect of farnesoid X receptor activation on metabolism in a diabetic rat model
Zhang, H., Wang, X., WU, Z.-H., LIU, H.-L., Chen, W., ZHANG, Z.-Z., Chen, D., & Zeng, T. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4761 · Cited by 26 · see citing works
PGC-1αand fasting-induced PDH regulation in mouse skeletal muscle
Gudiksen, A., & Pilegaard, H. (2017) · Physiological Reports · doi:10.14814/phy2.13222 · Cited by 26 · see citing works
Self-citationImpact of fasting followed by short-term exposure to interleukin-6 on cytochrome P450 mRNA in mice
Rasmussen, M. K., Bertholdt, L., Gudiksen, A., Pilegaard, H., & Knudsen, J. G. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.10.011 · Cited by 24 · see citing works
Self-citationImpact of skeletal muscle IL-6 on regulation of liver and adipose tissue metabolism during fasting
Bertholdt, L., Gudiksen, A., Jessen, H., & Pilegaard, H. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2185-1 · Cited by 24 · see citing works
Self-citationSkeletal muscle IL-6 and regulation of liver metabolism during high-fat diet and exercise training
Knudsen, J. G., Joensen, E., Bertholdt, L., Jessen, H., van Hauen, L., Hidalgo, J., & Pilegaard, H. (2016) · Physiological Reports · doi:10.14814/phy2.12788 · Cited by 23 · see citing works
Self-citationLack of skeletal muscle IL-6 influences hepatic glucose metabolism in mice during prolonged exercise
Bertholdt, L., Gudiksen, A., Schwartz, C. L., Knudsen, J. G., & Pilegaard, H. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00373.2016 · Cited by 20 · see citing works
Self-citationDethlefsen, M. M., Kristensen, C. M., Tøndering, A. S., Lassen, S. B., Ringholm, S., & Pilegaard, H. (2018) · Physiological Reports · doi:10.14814/phy2.13731 · Cited by 20 · see citing works
Self-citationPGC-1αin hepatic UPR during high-fat high-fructose diet and exercise training in mice
Kristensen, C. M., Dethlefsen, M. M., Tøndering, A. S., Lassen, S. B., Nøhr-Meldgaard, J., Ringholm, S., & Pilegaard, H. (2018) · Physiological Reports · doi:10.14814/phy2.13819 · Cited by 19 · see citing works
Self-citationPGC-1α in aging and lifelong exercise training-mediated regulation of UPR in mouse liver
Kristensen, C. M., Brandt, C. T., Ringholm, S., & Pilegaard, H. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.08.006 · Cited by 18 · see citing works
Self-citationFletcher, J. A., Linden, M. A., Sheldon, R. D., Meers, G. M.-E., Morris, E. M., Butterfield, A. M., Perfield, J. W., Rector, R. S., & Thyfault, J. P. (2017) · Experimental Physiology · doi:10.1113/ep086629 · Cited by 17 · see citing works
PGC-1α in exercise and fasting-induced regulation of hepatic UPR in mice
Kristensen, C. M., Olsen, M. A., Jessen, H., Brandt, N., Nøhr-Meldgaard, J., & Pilegaard, H. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2159-3 · Cited by 16 · see citing works
Self-citationZhao, B.-C., Tang, Y.-X., Qiu, B.-H., Xu, H.-L., Wang, T., Elsherbeni, A. I. A., Gharib, H. B., & Li, J. (2022) · Journal of Animal Science · doi:10.1093/jas/skac244 · Cited by 15 · see citing works
Muscle PGC ‐1α in exercise and fasting‐induced regulation of hepatic UPR in mice
Kristensen, C. M., Jessen, H., Ringholm, S., & Pilegaard, H. (2018) · Acta Physiologica · doi:10.1111/apha.13158 · Cited by 13 · see citing works
Self-citationKnock-in Luciferase Reporter Mice for In Vivo Monitoring of CREB Activity
Akhmedov, D., Rajendran, K., Mendoza‐Rodriguez, M. G., & Berdeaux, R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158274 · Cited by 11 · see citing works
Heiat, F., Heiat, M., & Shojaeifard, M. B. (2021) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.20.11693-1 · Cited by 11 · see citing works
McCaffrey, J. M., & Ibdah, J. A. (2025) · Nutrients · doi:10.3390/nu17182972 · Cited by 12 · see citing works
Rasmussen, M. K., Thøgersen, R., Lindholm, P. H., Bertram, H. C., & Pilegaard, H. (2022) · Gene · doi:10.1016/j.gene.2022.147039 · Cited by 9 · see citing works
Self-citationSexually dimorphic hepatic mitochondrial adaptations to exercise: a mini-review
Kugler, B. A., Thyfault, J. P., & McCoin, C. S. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00711.2022 · Cited by 5 · see citing works
Salem, G. A., Aref, M., El-Malkey, N. F., Alqahtani, H. A., Abd-Almotaleb, N. A., NASSAN, M. A., & Elsherbiny, H. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.102829 · Cited by 6 · see citing works
Banerjee, M., Song, J., Yan, B., Wu, H., Norouzi, S., Sengoku, T., Sharma, S., Fan, T. W. ‐., Lee, E. Y., He, D., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07664-3 · Cited by 6 · see citing works
Targeting Mitochondria with Sweat: Improving Mitochondrial Function with Physical Activity
Beleza, J., Rizo‐Roca, D., Ascensão, A. A. M. R., & Magalhães, J. (2018) · Springer eBooks · doi:10.1007/978-3-319-73344-9_18 · Cited by 6 · see citing works
Bertinat, R., Holyoak, T., Gatica, R., Jara, N., González‐Chavarría, I., & Westermeier, F. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102112 · Cited by 5 · see citing works
Ju, L., Tong, W., Qiu, M., Shen, W., Sun, J., Chen, Y., Li, Z., Wang, W., & Tian, J. (2016) · Endocrine Journal · doi:10.1507/endocrj.ej15-0479 · Cited by 5 · see citing works
Shinozaki, F., Abe, T., Kamei, A., Watanabe, Y. S., Yasuoka, A., Shimada, K., Kondo, K., Arai, S., Kumagai, K., Kondo, T., et al. (2016) · Genes & Nutrition · doi:10.1186/s12263-016-0534-2 · Cited by 5 · see citing works
Pros and cons of insulin administration on liver glucose metabolism in strength-trained healthy mice
Pereira, V. A. R., Vedovelli, K. S., Muller, G. Y., Depieri, Y. F., Avelar, D. H. C. G., de Amo, A. H. E., Jimenes, D. R., Martins, J., Silvério, A. C., Gomes, C. R. G., et al. (2019) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20187637 · Cited by 5 · see citing works
Gudiksen, A., Zhou, E., Pedersen, L., Zaia, C. A., Wille, C. E., Eliesen, E. V., & Pilegaard, H. (2025) · Mitochondrion · doi:10.1016/j.mito.2025.102034 · Cited by 3 · see citing works
Self-citationSchadock, I., Freitas, B. G., Moreira, I. D. L., Rincón, J. A. A., Corrêa, M. N., Zanella, R., da Silva, E. S., Araújo, R. C., Buchweitz, M. R. D., Helbig, E., et al. (2018) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000445 · Cited by 3 · see citing works
Possible physiological benefits of fasting and exercise
Pahlavani, H. A., & Veisi, A. (2025) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2025.2550470 · Cited by 2 · see citing works
Role and Regulation of Hepatic Metabolism During Exercise
Trefts, E., & Wasserman, D. H. (2022) · Physiology in health and disease · doi:10.1007/978-3-030-94305-9_11 · Cited by 2 · see citing works
Effect of Exercise on Carbohydrate and Lipid Metabolism in the Liver
Baghersalimi, M. (2018) · Cited by 2 · see citing works
Machrina, Y., Lindarto, D., Pane, Y. S., & Harahap, N. S. (2021) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2021.6362 · Cited by 1 · see citing works
Heat Shock Protein 72 Regulation of Metabolism
Archer, A. E. (2018) · KU ScholarWorks (The University of Kansas)
Kazemi, M., Abdi, A., Mehrabani, J., & Barari, A. (2023) · Armaghane Danesh · doi:10.61186/armaghanj.28.5.4
Ahmedpour, S., Barari, A., & Farzangi, P. (2023) · doi:10.32592/jsmj.22.3.354
Güneş, A., Jeromson, S., Schmitt, C., Schoumacher, M., Eng, J., Besse‐Patin, A., Léveillé, M., Monteillet, L., Jouvet, N., Baldwin, C., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.09.674670
Gao, Y., Tu, Z., Zhao, Q., Peng, J., Shu, Y., Ren, J., Deng, X., Chen, Y., Zhou, Y., Zeng, H., et al. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-03154-x
- Authors
- Haase, T. N., Ringholm, S., Leick, L., Biensø, R. S., Kiilerich, K., Johansen, S., Nielsen, M. M., Wojtaszewski, J. F., Hidalgo, J., Pedersen, P. A., & Pilegaard, H.
- Affiliations
- University of Copenhagen (DK)
- Universitat Autònoma de Barcelona (ES)
- Corresponding author
- Pilegaard, Henriette
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2011-11
- Volume
- 301
- Issue
- 5
- Pages
- R1501-R1509
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2051869636
- Cited by
- 66
- References
- 41
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2019: 4 · 2018: 12 · 2017: 9 · 2016: 10 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Sundhed og Sygdom, Det Frie Forskningsråd
- European Commission
- Danmarks Grundforskningsfond
- Fondation pour la Recherche Médicale
- Lundbeckfonden (R5-2006-225, R13-2007-1300)
- Region Hovedstaden
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- PGC-1α, PPARγ coactivator, fasting, acute exercise, exercise training, hepatic metabolism, gluconeogenesis, glucose-6-phosphatase, phosphoenolpyruvate carboxykinase, pyruvate carboxylase, cytochrome c, cytochrome c oxidase subunit I, mitochondrial biogenesis, oxidative capacity, antioxidant enzymes
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Superoxide Dismutase 2, Adaptation, Physiological, Animals, Antioxidants, Blood Glucose, Electron Transport Complex IV, Physical Exertion, Fasting, Gluconeogenesis, Glucose-6-Phosphatase, Glycogen, Liver, Phosphoenolpyruvate Carboxykinase (GTP), Phosphorylation, Pyruvate Carboxylase, RNA, Messenger, Superoxide Dismutase, Time Factors, Transcription Factors, Trans-Activators, Gene Expression Regulation, Enzymologic, Mice, Knockout, Cytochromes c, Mice, AMP-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
