The DOI matches its Crossref record; 62 of the 63 references it cites were found in a registry or an index.
Appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons
Abstract
Corticolimbic circuits involving the prefrontal cortex, amygdala, and ventral striatum determine the reward value of food and might play a role in environmentally induced obesity. Chemical manipulation of the nucleus accumbens shell (AcbSh) has been shown to elicit robust feeding and Fos expression in the hypothalamus and other brain areas of satiated rats. To determine the neurochemical phenotype of hypothalamic neurons receiving input from the AcbSh, we carried out c-Fos/peptide double-labeling immunohistochemistry in various hypothalamic areas known to contain feeding peptides, from rats that exhibited a significant feeding response after AcbSh microinjection of the GABA(A) agonist muscimol. In the perifornical area, a significantly higher percentage of orexin neurons expressed Fos after muscimol compared with saline injection. In contrast, Fos expression was not induced in melanin-concentrating hormone and cocaine-amphetamine-related transcript (CART) neurons. In the arcuate nucleus, Fos activation was significantly lower in neurons coexpressing CART and proopiomelanocortin, and there was a tendency for higher Fos expression in neuropeptide Y neurons. In the paraventricular nucleus, no significant activation of oxytocin and CART neurons was found. Thus AcbSh manipulation may elicit food intake through coordinated stimulation of hypothalamic neurons expressing orexigenic peptides and suppression of neurons expressing anorexigenic peptides. However, activation of many neurons not expressing these peptides suggests that additional peptides/transmitters in the lateral hypothalamus and accumbens projections to other brain areas might also be involved.
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“the chemical manipulation of the nucleus accumbens in rats resulted in the stimulation of orexigenic neurons and inhibition of anorexigenic neurons in the hypothalamus (35)”
From Effects of dietary glycemic index on brain regions related to reward and craving in men (2013) · cites this paper as [35]
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Metadata
- Authors
- Zheng, H., Corkern, M., Stoyanova, I., Patterson, L. M., Tian, R., & Berthoud, H.-R.
- Affiliations
- Pennington Biomedical Research Center (US)
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2003-06-01
- Volume
- 284
- Issue
- 6
- Pages
- R1436-R1444
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2040689703
- Cited by
- 135
- References
- 63
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 8 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 7
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-47348, R01DK047348)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- nucleus accumbens shell, hypothalamus, orexin neurons, proopiomelanocortin neurons, melanin-concentrating hormone neurons, neuropeptide Y neurons, oxytocin neurons, feeding behavior, food reward, corticolimbic circuits, muscimol microinjection, Fos expression, lateral hypothalamus
- MeSH terms
- Orexins, Cocaine- and Amphetamine-Regulated Transcript Protein, Animals, Appetite Regulation, Arcuate Nucleus of Hypothalamus, Carrier Proteins, Feeding Behavior, Gene Expression Regulation, Hypothalamic Hormones, Hypothalamus, Male, Melanins, Muscimol, Nerve Tissue Proteins, Neurons, Neuropeptide Y, Neuropeptides, Nucleus Accumbens, Oxytocin, Paraventricular Hypothalamic Nucleus, Pituitary Hormones, Pro-Opiomelanocortin, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, GABA Agonists, Intracellular Signaling Peptides and Proteins, Rats
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