Cited by 135Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorSleep and Wakefulness Research

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Appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons

Zheng, Huiyuan, Corkern, Michele, Stoyanova, Irina, Patterson, Laurel M., Tian, Rui, Berthoud, Hans-Rudolf·2003·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.00781.2002

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Abstract

Corticolimbic circuits involving the prefrontal cortex, amygdala, and ventral striatum determine the reward value of food and might play a role in environmentally induced obesity. Chemical manipulation of the nucleus accumbens shell (AcbSh) has been shown to elicit robust feeding and Fos expression in the hypothalamus and other brain areas of satiated rats. To determine the neurochemical phenotype of hypothalamic neurons receiving input from the AcbSh, we carried out c-Fos/peptide double-labeling immunohistochemistry in various hypothalamic areas known to contain feeding peptides, from rats that exhibited a significant feeding response after AcbSh microinjection of the GABA(A) agonist muscimol. In the perifornical area, a significantly higher percentage of orexin neurons expressed Fos after muscimol compared with saline injection. In contrast, Fos expression was not induced in melanin-concentrating hormone and cocaine-amphetamine-related transcript (CART) neurons. In the arcuate nucleus, Fos activation was significantly lower in neurons coexpressing CART and proopiomelanocortin, and there was a tendency for higher Fos expression in neuropeptide Y neurons. In the paraventricular nucleus, no significant activation of oxytocin and CART neurons was found. Thus AcbSh manipulation may elicit food intake through coordinated stimulation of hypothalamic neurons expressing orexigenic peptides and suppression of neurons expressing anorexigenic peptides. However, activation of many neurons not expressing these peptides suggests that additional peptides/transmitters in the lateral hypothalamus and accumbens projections to other brain areas might also be involved.

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Authors: Zheng, H., Corkern, M., Stoyanova, I., Patterson, L. M., Tian, R., & Berthoud, H.-R.
Affiliations: Pennington Biomedical Research Center (US)
ORCID: Zheng, Huiyuan
Berthoud, Hans-Rudolf
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 2003-06-01
Volume: 284
Issue: 6
Pages: R1436-R1444
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.00781.2002
OpenAlex: W2040689703
Cited by: 135
References: 63
Citations by year: 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 8 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 7
FWCI: 4.41
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK-47348, R01DK047348)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: nucleus accumbens shell, hypothalamus, orexin neurons, proopiomelanocortin neurons, melanin-concentrating hormone neurons, neuropeptide Y neurons, oxytocin neurons, feeding behavior, food reward, corticolimbic circuits, muscimol microinjection, Fos expression, lateral hypothalamus
MeSH terms: Orexins, Cocaine- and Amphetamine-Regulated Transcript Protein, Animals, Appetite Regulation, Arcuate Nucleus of Hypothalamus, Carrier Proteins, Feeding Behavior, Gene Expression Regulation, Hypothalamic Hormones, Hypothalamus, Male, Melanins, Muscimol, Nerve Tissue Proteins, Neurons, Neuropeptide Y, Neuropeptides, Nucleus Accumbens, Oxytocin, Paraventricular Hypothalamic Nucleus, Pituitary Hormones, Pro-Opiomelanocortin, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, GABA Agonists, Intracellular Signaling Peptides and Proteins, Rats

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Appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons

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