The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Cholecystokinin suppresses food intake by inhibiting gastric emptying
Open accessAbstract
In a search for the physiological mechanisms that could mediate and characterize a satiety function for the hormone cholecystokinin (CCK), we examined in Macaca mulatta the effect of intraperitoneal injections (0.1-0.8 microgram/kg) and intravenous infusions (60-240 ng.kg-1.h-1) of the C-terminal octapeptide of CCK on gastric emptying of saline test meals. Within these dose ranges, gastric emptying was inhibited by this hormone to a degree comparable with that produced by intraintestinal nutrient. The onset of the inhibition is rapid and its effect brief. At the doses of CCK that produce gastric inhibition, CCK would not affect feeding in a fasted monkey unless the stomach was filled with saline. This result suggests that a satiety influence of circulating CCK is an indirect one. The satiety effect depends upon inhibition of gastric emptying, which then leads to gastric distention with further food injection. CCK thus can be considered a link in a chain of physiological elements producing the short-term satiety that leads to the appropriate interruption of a meal or bout of feeding behavior.
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Citations
Cites
Cholecystokinin decreases food intake in rats.
Gibbs, J., Young, R. C., & Smith, G. P. (1973) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0034870 · Cited by 1,491
Hypothalamic control of food intake in rats and cats.
Anand, B. K., & Brobeck, J. R. (1951) · PubMed Central · Cited by 1,209
Cholecystokinin elicits the complete behavioral sequence of satiety in rats.
Antin, J., Gibbs, J., Holt, J., Young, R. C., & Smith, G. P. (1975) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077040 · Cited by 613
C-terminal octapeptide of cholecystokinin decreases food intake in man
Kissileff, H. R., Pi-Sunyer, F. X., Thornton, J., & Smith, G. P. (1981) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/34.2.154 · Cited by 598
Cholecystokinin elicits Satiety in Rats with Open Gastric Fistulas
GIBBS, J., YOUNG, R. C., & SMITH, G. P. (1973) · Nature · doi:10.1038/245323a0 · Cited by 534
Cannon, W. B., & Washburn, A. L. (1912) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1912.29.5.441 · Cited by 293
Inhibition of Gastric Emptying is a Physiological Action of Cholecystokinin
Debas, H. T., Farooq, O., & Grossman, M. I. (1975) · Gastroenterology · doi:10.1016/s0016-5085(75)80236-8 · Cited by 277
Paintal, A. S. (1954) · The Journal of Physiology · doi:10.1113/jphysiol.1954.sp005207 · Cited by 269
Calories and gastric emptying: a regulatory capacity with implications for feeding
McHugh, P. R., & Moran, T. H. (1979) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1979.236.5.r254 · Cited by 235
Self-citationDistinctions among three sugars in their effects on gastric emptying and satiety
Moran, T. H., & McHugh, P. R. (1981) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1981.241.1.r25 · Cited by 97
Self-citation
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Effects of Diet on Short-Term Regulation of Feed Intake by Lactating Dairy Cattle
Allen, M. S. (2000) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(00)75030-2 · Cited by 1,550
Gastrointestinal regulation of food intake
Cummings, D. E., & Overduin, J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30227 · Cited by 1,216
Proinflammatory Cytokines, Aging, and Age-Related Diseases
Michaud, M., Balardy, L., Moulis, G., Gaudin, C., Peyrot, C., Vellas, B., Cesari, M., & Nourhashemi, F. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.009 · Cited by 1,094
Glucagon-like peptide-1 receptor: mechanisms and advances in therapy
Zheng, Z., Zong, Y., Ma, Y., Tian, Y., Pang, Y., Zhang, C., & Gao, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01931-z · Cited by 1,036
“270,271 Additionally, slower gastric emptying helps stabilize postprandial blood glucose levels.”
BackgroundHindbrain Neurons as an Essential Hub in the Neuroanatomically Distributed Control of Energy Balance
Grill, H. J., & Hayes, M. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.015 · Cited by 485
Metadata
- Authors
- Moran, T. H., & McHugh, P. R.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1982-05-01
- Volume
- 242
- Issue
- 5
- Pages
- R491-R497
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2461429252
- Cited by
- 339
- References
- 16
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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