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Cholecystokinin elicits the complete behavioral sequence of satiety in rats.

Antin, Joseph, Gibbs, James, Holt, Jonathan, Young, Robert C., Smith, Gerard P.·1975·Journal of Comparative and Physiological Psychology

Abstract

The behavior of intact rats and rats with chronic gastric fistulas was observed and scored during a 60-min test period when they were offered liquid diet after 17 hr of food deprivation. Intact rats and rats with closed fistulas displayed a specific behavioral sequence at the end of each meal: They stopped eating, engaged in grooming and exploration for a short time, and then rested or slept. Thus, a fixed behavioral sequence characterizes satiety in the rat. Although the behavioral sequence of satiety was fixed, the cessation of feeding was not a sufficient condition for the appearance of the rest of the sequence: Quinine adulteration of the liquid diet stopped sham feeding but did not elicit the complete sequence. Intraperitoneal injection of the intestinal hormone cholecystokinin during sham feeding, however, elicited the complete sequence of satiety. The observation that cholecystokinin not only stops feeding but elicits the complete sequence of satiety supports our hypothesis that endogenous cholecystokinin is a satiety signal for the rat.

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Metadata

Authors
Antin, J., Gibbs, J., Holt, J., Young, R. C., & Smith, G. P.
Venue
Journal of Comparative and Physiological Psychology
Published
1975
Volume
89
Issue
7
Pages
784-790
ISSN
0021-9940 (ISSN-L)
OpenAlex
W2030307471
Cited by
613
References
0
FWCI
7.70
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Cholecystokinin elicits the complete behavioral sequence of satiety in rats. https://app.cochat.ai/papers/10.1037/h0077040
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Antin, J., Gibbs, J., Holt, J., Young, R. C., & Smith, G. P. (1975). Cholecystokinin elicits the complete behavioral sequence of satiety in rats. Journal of Comparative and Physiological Psychology. https://doi.org/10.1037/h0077040

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.