Trabecular bone remodeling after seven days of weightlessness exposure (BIOCOSMOS 1667)
Abstract
Seven male rats were exposed to 7 days of weightlessness in the Soviet mission COSMOS 1667 and compared with seven control rats by bone histomorphometric methods. In proximal tibial metaphysis, the trabecular bone volume was markedly reduced in flight animals. Trabeculae were decreased in number and thickness; this probably leads to alteration of bone mechanical properties. Formation activity (reflected by measurements of osteoid seams) was decreased at trabecular and endosteal levels. Resorption activity (estimated by count of osteoclast number and active resorption surfaces using a histoenzymologic method) remained unchanged. The imbalance between these cellular activities appears to be responsible for the loss of trabecular bone mass. In proximal femoral metaphysis, measurements were performed in an area located under the muscular insertions. The trabecular bone volume, despite a slight decrease in flight rats, was not significantly different from that of control rats. Furthermore, osteoclastic and osteoid parameters were unchanged. Differential responses between these two long bones need additional investigations. In thoracic and lumbar vertebrae no detectable change in bone mass and bone resorption parameters was found.
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In the same rat spaceflight study, femoral trabecular bone at the site of muscular insertions and vertebral bone showed no significant changes compared to ground controls.
“In contrast, femoral trabecular bone at the site of muscular insertions and vertebral bone showed no significant changes when compared to ground controls.”
From Osteoclasts and Microgravity (2020) · cites this paper as [57]
In seven Wistar rats flown for seven days aboard BIOCOSMOS 1667, microgravity reduced tibial trabecular bone volume by 47-55%, trabecular thickness by 20-24%, and trabecular density by 40-43% compared to ground controls.
“Microgravity reduced tibial trabecular bone volume by 47–55%, trabecular thickness by 20–24%, and trabecular density by 40–43% as compared to ground controls.”
From Osteoclasts and Microgravity (2020) · cites this paper as [57]
Conditions of microgravity and simulated microgravity decrease the mineral content and cortical and trabecular microstructures of bone.
“conditions of microgravity and simulated microgravity decrease the mineral content and cortical and trabecular microstructures of bone”
From Osteoclasts and Microgravity (2020) · cites this paper as [57]
Conditions of microgravity and simulated microgravity decrease osteoblastogenesis and osteoblast secretion of OPG.
“decrease osteoblastogenesis and osteoblast secretion of OPG”
From Osteoclasts and Microgravity (2020) · cites this paper as [57]
Conditions of microgravity and simulated microgravity increase osteoclast secretion of sclerostin.
“increase osteoclast secretion of sclerostin”
From Osteoclasts and Microgravity (2020) · cites this paper as [57]
Conditions of microgravity and simulated microgravity increase osteoclast differentiation, fusion, and expression of regulatory and osteoclast-specific genes.
“increase osteoclast differentiation, fusion, and expression of regulatory and osteoclast-specific genes”
From Osteoclasts and Microgravity (2020) · cites this paper as [57]
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- Authors
- Vico, L., Chappard, D., Palle, S., Bakulin, A. V., Novikov, V. E., & Alexandre, C.
- Affiliations
- Laboratoire de Biologie du Tissu Osseux, Faculte de Medecine, Saint Etienne, France.
- ORCID
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1988-08-01
- Volume
- 255
- Issue
- 2
- Pages
- R243-R247
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2189587829
- Cited by
- 99
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 2 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- trabecular bone remodeling, microgravity, spaceflight, bone loss, trabecular bone volume, osteoid seams, osteoclasts, bone resorption, bone formation, tibial metaphysis, femoral metaphysis, vertebrae, rats
- MeSH terms
- Animals, Bone and Bones, Bone Resorption, Femur, Male, Osteoclasts, Rats, Inbred Strains, Reference Values, Tibia, Weightlessness, Rats
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