Hypothalamic peptide regulation of ACTH secretion from sheep pituitary
Abstract
The relative abilities of the hypothalamic peptides corticotropin-releasing factor (CRF), arginine vasopressin (AVP), oxytocin (OT), and angiotensin II (ANG II) to stimulate adrenocorticotropic hormone (ACTH) secretion from cultured sheep anterior pituitary cells were studied. Incubation of cells with CRF, AVP, and OT, but not ANG II, was associated with increased ACTH secretion. CRF and AVP were equally effective in stimulating ACTH release at 0.1 nM, but larger doses of each resulted in distinctly different ACTH secretory patterns. The minimally effective dose of OT was 10 nM; greater doses of this peptide resulted in ACTH secretory responses similar to those measured after addition of AVP. Cotreatment with ANG II did not affect the ACTH-secretory response to CRF, AVP, or OT. These data confirm that AVP is a potent stimulus for ACTH secretion from sheep anterior pituitary in vitro and also show that CRF is effective in low concentrations in releasing ACTH. In contrast, the data do not support a regulatory role for ANG II in stimulating ACTH release directly from sheep corticotroph cells.
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Synergistic stimulation of ACTH production and secretion by corticotrope cells by CRH and AVP could yield a several-fold higher output than either one individually.
“Their synergistic stimulation of ACTH production and secretion by corticotrope cells could yield a several-fold higher output than due to the action of either one individually (26, 34–41, 43–47).”
From Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis (2022) · cites this paper as [35]
Both CRH and AVP act on their own receptors on corticotrope cells in the anterior pituitary to stimulate ACTH production and release, with different or even similar potencies.
“Namely, it has been indicated that both CRH and AVP act on their own receptors (28–32) on corticotrope cells in anterior pituitary to stimulate adrenocorticotropic hormone (ACTH) production and release with different (26, 33–41) or even similar potencies (42).”
From Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis (2022) · cites this paper as [35]
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- Authors
- Kemppainen, R. J., Clark, T. P., Sartin, J. L., & Zerbe, C. A.
- Affiliations
- Auburn University (US)
- ORCID
- Kemppainen, R. J.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1993-10-01
- Volume
- 265
- Issue
- 4
- Pages
- R840-R845
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2287194487
- Cited by
- 22
- References
- 0
- Citations by year
- 2022: 1 · 2019: 1
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- ACTH secretion, corticotropin-releasing factor, vasopressin, oxytocin, angiotensin II, hypothalamic neuropeptides, anterior pituitary cells, sheep, corticotrophs, dose-response relationship
- MeSH terms
- Adrenocorticotropic Hormone, Angiotensin II, Animals, Arginine Vasopressin, Cells, Cultured, Corticotropin-Releasing Hormone, Dose-Response Relationship, Drug, Drug Interactions, Hypothalamus, Immunohistochemistry, Intracellular Membranes, Oxytocin, Peptides, Pituitary Gland, Sheep, Tetradecanoylphorbol Acetate, Rats
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