A method for selective section of vagal afferent or efferent axons in the rat
Abstract
Although normally a mixed nerve, intracranially the vagus separates into dorsal rootlets that contain afferent axons and ventral rootlets that contain efferents. Surgical procedures are described for exposing the ventral surface of the occipital bone at the level where the vagus passes through the posterior lacerated foramen. When the foramen is expanded medially and the dura lanced, the intracranial course of the vagus can be observed by use of an operating microscope. Under these conditions, either the efferent or the afferent rootlets can be severed selectively. When the dorsal rootlets are divided and the contralateral trunk is cut below the diaphragm, a selective bilateral subdiaphragmatic afferent vagotomy is produced with unilateral sparing of the efferents. Cutting the efferents intracranially has the converse effect.
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Subdiaphragmatic vagal deafferentation highlights the involvement of vagal afferents in anxiety-like and fear-related behavior.
“In addition, subdiaphragmatic vagal deafferentation (Vazquez et al., 2016) a method that eliminates abdominal vagal afferents, but keeps most efferents intact (Norgren and Smith, 1994) highlights the involvement of vagal afferents in anxiety-like (elevated plus maze, open-field test, food neophobia) and fear-related behavior (auditory-cued fear conditioning) (Klarer et al.,”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Norgren and Smith, 1994
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- Authors
- Norgren, R., & Smith, G. P.
- Affiliations
- Pennsylvania State University (US)
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1994-10-01
- Volume
- 267
- Issue
- 4
- Pages
- R1136-R1141
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2197487676
- Cited by
- 90
- References
- 0
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 8 · 2014: 6 · 2012: 6
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH-00653)
- National Institute on Deafness and Other Communication Disorders (DC 00240, R01DC000240)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK33248)
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- vagus nerve, selective vagotomy, vagal afferents, vagal efferent fibers, dorsal rootlets, occipital bone, subdiaphragmatic vagotomy
- MeSH terms
- Afferent Pathways, Animals, Axons, Axonal Transport, Efferent Pathways, Horseradish Peroxidase, Medulla Oblongata, Neurophysiology, Neurosurgery, Vagus Nerve, Wheat Germ Agglutinins, Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate, Rats
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