The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Glucocorticoids and insulin: reciprocal signals for energy balance
Abstract
Signals that regulate long-term energy balance have been difficult to identify. Increasingly strong evidence indicates that insulin, acting on the central nervous system in part through its effect on neuropeptide Y (NPY), inhibits food intake. We hypothesized that corticosteroids and insulin might serve as interacting, reciprocal signals for energy balance, acting on energy acquisition, in part through their effects on hypothalamic NPY, as well as on energy stores. Because glucocorticoids also stimulate insulin secretion, their role is normally obscured. Glucocorticoids and insulin were clamped in adrenalectomized rats with steroid replacement and streptozotocin-induced diabetes. Glucocorticoids stimulated and insulin inhibited NPY mRNA and food intake. Glucocorticoids inhibited and insulin increased energy gain as determined by the change in body weight. When adrenalectomized diabetic rats were treated, corticosterone stimulated and insulin inhibited food intake, and, respectively, inhibited and increased overall energy gain. More than 50% of the variance was explained by regression analysis of the two hormones on food intake and body weight. Thus glucocorticoids and insulin are major, antagonistic, long-term regulators of energy balance. The effects of corticosterone and insulin on food intake may be mediated, in part, through regulation of hypothalamic NPY synthesis and secretion.
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Cites
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Self-citationFeast and Famine: Critical Role of Glucocorticoids with Insulin in Daily Energy Flow
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Self-citationSeasonal changes of the adrenocortical response to stress in birds of the Sonoran desert
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Inhibition of hypothalamic neuropeptide Y gene expression by insulin.
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Self-citationTissue effects of glucocorticoids
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Cited by
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Sapolsky, R. M. (2000) · Endocrine Reviews · doi:10.1210/er.21.1.55 · Cited by 7,533
Cortisol in teleosts: dynamics, mechanisms of action, and metabolic regulation
Mommsen, T. P., Vijayan, M. M., & Moon, T. W. (1999) · Reviews in Fish Biology and Fisheries · doi:10.1023/a:1008924418720 · Cited by 2,324
Chronic stress and obesity: a new view of “comfort food”
Dallman, M. F., Pecoraro, N., Akana, S. F., la Fleur, S. E., Gomez, F., Houshyar, H., Bell, M. E., Bhatnagar, S., Laugero, K. D., & Manalo, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1934666100 · Cited by 1,369
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Metadata
- Authors
- Strack, A. M., Sebastian, R. J., Schwartz, M. W., & Dallman, M. F.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1995-01-01
- Volume
- 268
- Issue
- 1
- Pages
- R142-R149
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2233173144
- Cited by
- 334
- References
- 31
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Strack, A. M., Sebastian, R. J., Schwartz, M. W., & Dallman, M. F. (1995). Glucocorticoids and insulin: reciprocal signals for energy balance. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.1995.268.1.r142
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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