The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity
Abstract
Chronic intracerebroventricular (icv) administration of neuropeptide-Y (NPY; 10 micrograms/day) was performed in normal female rats to investigate its hormonal and metabolic consequences. Intracerebroventricular NPY produced hyperphagia, increased basal insulinemia, as well as liver and adipose tissue lipogenic activity. It also increased basal morning corticosteronemia. When NPY-induced hyperphagia was prevented by pair-feeding, the icv NPY treatment resulted in the same increases in basal insulinemia and corticosteronemia, and liver and white adipose tissue lipogenesis was still higher than that in respective controls. Under the ad libitum and pair-feeding conditions, icv NPY stimulated glucose uptake as well as total lipoprotein lipase activity in white adipose tissue; it resulted in an increase total activity of hepatic and white adipose tissue acetyl coenzyme-A-carboxylase. As all hormonal and metabolic changes elicited by icv NPY remained present (at the same or to a lesser extent depending upon the parameter considered) when hyperphagia was prevented by pair-feeding, it was, thus, shown that icv NPY per se induces peripheral hormonal and metabolic alterations via efferent routes, which remain to be determined. The effects of icv NPY reported in this study are similar to the defects observed in the early phase of genetic obesity in rodents, the hypothalamus of which has increased NPY levels. NPY could, thus, be of relevance in the occurrence of genetically induced obesity.
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Cites
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189
Coated Charcoal Immunoassay of Insulin
HERBERT, V., LAU, K.-S., GOTTLIEB, C. W., & BLEICHER, S. J. (1965) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-25-10-1375 · Cited by 2,968
NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS
Clark, J. T., Kalra, P. S., Crowley, W. R., & Kalra, S. P. (1984) · Endocrinology · doi:10.1210/endo-115-1-427 · Cited by 1,276
Glenn Stanley, B., Kyrkouli, S. E., Lampert, S., & Leibowitz, S. F. (1986) · Peptides · doi:10.1016/0196-9781(86)90149-x · Cited by 849
Altered Expression of Hypothalamic Neuropeptide mRNAs in Food-Restricted and Food-Deprived Rats
Brady, L. S., Smith, M. A., Gold, P. W., & Herkenham, M. (1990) · Neuroendocrinology · doi:10.1159/000125626 · Cited by 641
Inhibition of hypothalamic neuropeptide Y gene expression by insulin.
Schwartz, M. W., Sipols, A. J., Marks, J. L., Sanacora, G., White, J. D., Scheurink, A., Kahn, S. E., Baskin, D. G., Woods, S. C., & Figlewicz, D. P. (1992) · Endocrinology · doi:10.1210/endo.130.6.1597158 · Cited by 555
Bai, F. L., Yamano, M., Shiotani, Y., Emson, P. C., Smith, A. D., Powell, J. F., & Tohyama, M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90730-9 · Cited by 524
Sahu, A., Kalra, P. S., & Kalra, S. P. (1988) · Peptides · doi:10.1016/0196-9781(88)90013-7 · Cited by 503
Insulin and Obesity in the Zucker Genetically Obese Rat “Fatty”
ZUCKER, L. M., & ANTONIADES, H. N. (1972) · Endocrinology · doi:10.1210/endo-90-5-1320 · Cited by 418
Effect of neuropeptide Y on ingestive behaviors in the rat
Morley, J. E., Levine, A. S., Gosnell, B. A., Kneip, J., & Grace, M. (1987) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1987.252.3.r599 · Cited by 292
Cited by
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
Stress, eating and the reward system
Adam, T. C., & Epel, E. S. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.011 · Cited by 1,732
The role of neuropeptide Y in the antiobesity action of the obese gene product
Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., et al. (1995) · Nature · doi:10.1038/377530a0 · Cited by 1,498
Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies
Han, J.-S. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)00006-1 · Cited by 1,084
Metadata
- Authors
- Zarjevski, N.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1993-10-01
- Volume
- 133
- Issue
- 4
- Pages
- 1753-1758
- ISSN
- 0013-7227 (ISSN-L)
- OpenAlex
- W2067020358
- Cited by
- 480
- References
- 29
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- closed
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