Entrainment of Syrian hamster circadian activity rhythms by neonatal melatonin injections

Grosse, J.; Velickovic, A.; Davis, F. C.

doi:10.1152/ajpregu.1996.270.3.r533

Cited by 47Circadian rhythm and melatoninSleep and Wakefulness ResearchHypothalamic control of reproductive hormones

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Entrainment of Syrian hamster circadian activity rhythms by neonatal melatonin injections

Grosse, J., Velickovic, A., Davis, F. C.·1996·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.1996.270.3.r533

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Abstract

The circadian rhythms of fetal and neonatal rodents are entrained by their mother. This entrainment is dependent upon the maternal suprachiasmatic nucleus (SCN), but the mechanism of entrainment is unknown. Administration of the pineal hormone melatonin to pregnant, SCN-lesioned female Syrian hamsters entrains the activity rhythms of their hamster pups. The aim of this study was to determine whether melatonin injected directly in neonatal Syrian hamsters is able to entrain circadian rhythms and, if so, for how long this effect persists during development. Injection of melatonin in two groups of hamster pups at opposite phases on postnatal days 1-5 entrained the onset of activity rhythms on the day of weaning to two phases 10.67 h apart. Melatonin injection did not entrain activity rhythms to opposite phases on either postnatal days 6-10 or 21-25. Vehicle injection did not entrain animals to opposite phases at any of the ages studied. These results demonstrate that melatonin is able to act directly on the neonate to cause entrainment and that this effect disappears after postnatal day 6.

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The failure of stable maternal rhythms to rescue offspring outcomes is in contrast with ELS and maternal melatonin literature, in which neonatal interventions rescue circadian- and ELS-induced effects in offspring.
“The failure of stable maternal rhythms to rescue offspring outcomes are in contrast with both the ELS and maternal melatonin literature, in which neonatal interventions rescue circadian-22, 53–55 and ELS-induced effects in offspring56.”
From Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice (2017) · cites this paper as [55]

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Authors: Grosse, J., Velickovic, A., & Davis, F. C.
Affiliations: Northeastern University (US)
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 1996-03-01
Volume: 270
Issue: 3
Pages: R533-R540
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.1996.270.3.r533
OpenAlex: W2200251599
Cited by: 47
References: 0
Citations by year: 2022: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2012: 1
FWCI: 1.96
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 18686)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: melatonin, circadian entrainment, neonatal development, golden hamster, activity rhythms, suprachiasmatic nucleus, pineal gland, postnatal development, weaning
MeSH terms: Animals, Animals, Newborn, Circadian Rhythm, Female, Cricetinae, Male, Melatonin, Mesocricetus, Pregnancy, Suprachiasmatic Nucleus

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Entrainment of Syrian hamster circadian activity rhythms by neonatal melatonin injections

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