Melatonin: role in development
Open accessAbstract
Melatonin is the mammalian fetus's window to periodicity of the outside world. Through melatonin, the fetus "knows" what time of year it is and, in all likelihood, also knows the time of day. The best known function of melatonin during development is to communicate information about photoperiod and thereby adaptively regulate reproductive development. A second likely function of melatonin during development, which may be related to but more widespread than the first, is to entrain the developing circadian pacemaker. Prenatal maternal entrainment occurs in all of the eutherian mammals in which it has been examined, and in Syrian hamsters exogenous melatonin during development causes entrainment. The broader distribution and greater abundance of melatonin receptors during development, relative to mature animals, suggests that developmental effects of melatonin are greater and more diverse. The human fetal suprachiasmatic nucleus expresses melatonin binding sites and is therefore likely to be affected by both endogenous and exogenous melatonin with consequences for the prenatal and postnatal expression and entrainment of circadian rhythms. Caution is warranted, not only concerning the use of exogenous melatonin during pregnancy and lactation but also concerning behavior that might disrupt the mother's endogenous melatonin rhythm.
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The development of the 24-h circadian rest-activity rhythm is observed in infants as young as 3 weeks old and is potentially influenced by a mother's rest-activity cycle and maternal melatonin rhythm.
“After birth, the development of the 24-h circadian rest-activity rhythm is observed in infants as young as 3 wk old and is potentially influenced by a mother's rest-activity cycle (88) and maternal melatonin rhythm (89).”
From Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health (2019) · cites this paper as [89]
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Newport, D. J., di Scalea, T. L., Richardson, E., Smith, T. L., Scott, N. P., & Stowe, Z. N. (2024) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615375523.as63 · Cited by 1 · see citing works
Anti-Aging Medicine LiteratureWatch
Pawelec, G. (1998) · Rejuvenation Research · doi:10.1089/rej.1.1998.1.275
CHRONONEONATOLOGY: BIORHYTHMIC ENTITY OF A NEWBORN
Pishak, V. P., & Ryznychuk, М. О. (2019) · Neonatology surgery and perinatal medicine · doi:10.24061/2413-4260.ix.2.32.2019.12
Anti-Aging Medicine LiteratureWatch
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Manfredini, M., Breschi, M., Fornasin, A., & Esposito, M. (2022) · Population Studies · doi:10.1080/00324728.2022.2099566
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Voiculescu, S. E., Duc, D. L., Roşca, A. E., & Zăgrean, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-443-23940-3.00020-x
Circadian rhythms in pediatric neurocritical care: interfaces and opportunities
Babinchak, W. M., & Lipton, J. O. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1826615
- Authors
- Davis, F. C.
- Affiliations
- Northeastern University (US)
- Corresponding author
- Davis, Fred C.
- Venue
- Journal of Biological Rhythms
- Publisher
- SAGE Publications
- Published
- 1997-12
- Volume
- 12
- Issue
- 6
- Pages
- 498-508
- ISSN
- 0748-7304 (ISSN-L)
- 1552-4531
- OpenAlex
- W1984501931
- Cited by
- 90
- References
- 29
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 4 · 2012: 3
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Biological Rhythms (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 18686)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- melatonin, fetal development, photoperiod, reproductive development, circadian entrainment, circadian pacemaker, suprachiasmatic nucleus, melatonin receptors, prenatal exposure, exogenous melatonin, golden hamster, placental mammals, seasonal adaptation
- MeSH terms
- Animals, Circadian Rhythm, Female, Embryonic and Fetal Development, Fetus, Cricetinae, Humans, Melatonin, Pregnancy, Sexual Maturation
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