The DOI matches its Crossref record; 238 of the 238 references it cites were found in a registry or an index.
Tumor necrosis factor in the heart
Abstract
The heart is a tumor necrosis factor (TNF)-producing organ. Both myocardial macrophages and cardiac myocytes themselves synthesize TNF. Accumulating evidence indicates that myocardial TNF is an autocrine contributor to myocardial dysfunction and cardiomyocyte death in ischemia-reperfusion injury, sepsis, chronic heart failure, viral myocarditis, and cardiac allograft rejection. Indeed, locally (vs. systemically) produced TNF contributes to postischemic myocardial dysfunction via direct depression of contractility and induction of myocyte apoptosis. Lipopolysaccharide or ischemia-reperfusion activates myocardial P38 mitogen-activated protein (MAP) kinase and nuclear factor kappa B, which lead to TNF production. TNF depresses myocardial function by nitric oxide (NO)-dependent and NO-independent (sphingosine dependent) mechanisms. TNF activation of TNF receptor 1 or Fas may induce cardiac myocyte apoptosis. MAP kinases and TNF transcription factors are feasible targets for anti-TNF (i.e., cardioprotective) strategies. Endogenous anti-inflammatory ligands, which trigger the gp130 signaling cascade, heat shock proteins, and TNF-binding proteins, also control TNF production and activity. Thus modulation of TNF in cardiovascular disease represents a realistic goal for clinical medicine.
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The clinical implications of endothelial dysfunction
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Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension
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The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation
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Metadata
- Authors
- Meldrum, D. R.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1998-03-01
- Volume
- 274
- Issue
- 3
- Pages
- R577-R595
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2182141197
- Cited by
- 746
- References
- 238
- FWCI
- 24.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Meldrum, D. R. (1998). Tumor necrosis factor in the heart. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.1998.274.3.r577
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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