Brain-blood permeability: TNF-α promotes escape of protein tracer from CSF to blood
Abstract
The objective of this study was to determine the effect of tumor necrosis factor (TNF)-α on the efflux of protein from the central nervous system to blood based on assessing the clearance of radiolabeled albumin from the cerebrospinal fluid (CSF) to blood in rats. 125 I-labeled human serum albumin (125 I-HSA) was injected into a lateral ventricle, and venous blood was sampled hourly to determine the basal CSF protein clearance into the blood. After this, rats were intraventricularly infused with 10 μl TNF-α and 10 μl 131 I-HSA ( n = 6) or 10 μl saline and 10 μl 131 I-HSA ( n = 6). Venous blood was sampled hourly for 3 h. 131 I-HSA tracer recovery increased threefold in the venous blood and was significantly higher in the spleen, muscles, and skin in animals treated with TNF-α. No significant changes were observed in control animals treated with saline. The data suggest that TNF-α promotes the clearance of protein macromolecules from the CSF to the venous blood.
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Both the glymphatic and the lymphatic systems eventually redirect proteins including sleep regulatory substances into lymph nodes and then into the circulation for final clearance by the liver or the kidneys.
“Both the glymphatic and the lymphatic systems eventually redirect proteins including sleep regulatory substances into lymph nodes and then into the circulation for final clearance by the liver or the kidneys”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [145]
Cites
The influence of cytokines on the integrity of the blood-brain barrier in vitro
de Vries, H. E., Blom-Roosemalen, M. C. M., van Oosten, M., de Boer, A. G., van Berkel, T. J. C., Breimer, D. D., & Kuiper, J. (1996) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00148-4 · Cited by 666 · see citing works
Murine tumor necrosis factor alpha is transported from blood to brain in the mouse
Gutierrez, E. G., Banks, W. A., & Kastin, A. J. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90027-v · Cited by 577 · see citing works
Kida, S., Pantazis, A., & Weller, R. O. (1993) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1993.tb00476.x · Cited by 520 · see citing works
Brett, J., Gerlach, H., Nawroth, P. P., Steinberg, S. F., Godman, G. C., & Stern, D. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.6.1977 · Cited by 408 · see citing works
THE CEREBROSPINAL FLUID VALVES
Welch, K., & FRIEDMAN, V. (1960) · Brain · doi:10.1093/brain/83.3.454 · Cited by 320 · see citing works
Megyeri, P., Ábrahám, C. S., Temesvári, P., Kovács, J., Vas, T., & Speer, C. P. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90823-p · Cited by 193 · see citing works
Experimental biology of the lymphatic circulation
Johnston, M. G. (1985) · Elsevier eBooks · Cited by 156 · see citing works
Kim, K. S., Wass, C. A., Cross, A. S., & Opal, S. M. (1992) · PubMed · Cited by 151 · see citing works
Boulton, M., Flessner, M. F., Armstrong, D. W., Mohamed, R., Hay, J. B., & Johnston, M. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.3.r818 · Cited by 140 · see citing works
Self-citationBoulton, M., Armstrong, D. W., Flessner, M. F., Hay, J. B., Szalai, J. P., & Johnston, M. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.3.r889 · Cited by 116 · see citing works
Self-citationTureen, J. H. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117755 · Cited by 103 · see citing works
Bodnar, R. J., Pasternak, G. W., Mann, P. E., Paúl, D., Warren, R. S., & Donner, D. B. (1989) · PubMed · Cited by 102 · see citing works
Klemm, P. L., Warner, T. D., Hohlfeld, T., et al. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.2691 · Cited by 86 · see citing works
Boulton, M., Flessner, M. F., Armstrong, D. W., et al. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.5.r1613 · Cited by 79 · see citing works
Intracerebroventricular injection of TNF-α promotes sleep and is recovered in cervical lymph
Dickstein, J. B., Moldofsky, H., Lue, F. A., & Hay, J. B. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.4.r1018 · Cited by 54 · see citing works
Self-citationBrain ion and volume regulation during acute hypernatremia in Brattleboro rats
Depasquale, M. J., Patlak, C. S., & Cserr, H. F. (1989) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1989.256.6.f1059 · Cited by 53 · see citing works
Partridge, C. A., Horvath, C. J., Vecchio, P. J. D., et al. (1992) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1992.263.6.l627 · Cited by 51 · see citing works
Chen, G., & Reichlin, S. (1998) · NeuroImmunoModulation · doi:10.1159/000026346 · Cited by 39 · see citing works
Tumor necrosis factor-α induces pial arteriolar dilation in newborn pigs
Shibata, M., Parfenova, H., Zuckerman, S. L., et al. (1996) · Brain Research Bulletin · doi:10.1016/0361-9230(95)02142-6 · Cited by 35 · see citing works
Angstwurm, K., Freyer, D., Dirnagl, U., et al. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00032-3 · Cited by 31 · see citing works
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The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works
- Authors
- Dickstein, J. B., Moldofsky, H., & Hay, J. B.
- Affiliations
- Centre for Sleep and Chronobiology,
- University of Toronto (CA)
- ORCID
- Moldofsky, Harvey
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2000-07-01
- Volume
- 279
- Issue
- 1
- Pages
- R148-R151
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2190166237
- Cited by
- 29
- References
- 20
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 4 · 2017: 3 · 2016: 2 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- TNF-α, cerebrospinal fluid, intraventricular infusion, radiolabeled albumin, spleen, skin, muscle, neuroinflammation
- MeSH terms
- Animals, Blood-Brain Barrier, Capillary Permeability, Cerebrospinal Fluid, Humans, Injections, Intraventricular, Lymph Nodes, Male, Metabolic Clearance Rate, Proteins, Serum Albumin, Radio-Iodinated, Skin, Spleen, Tumor Necrosis Factor-alpha, Rats, Wistar, Muscle, Skeletal, Rats
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