Microbial experimental evolution
Abstract
Microbes have been widely used in experimental evolutionary studies because they possess a variety of valuable traits that facilitate large-scale experimentation. Many replicated populations can be cultured in the laboratory simultaneously along with appropriate controls. Short generation times and large population sizes make microbes ideal experimental subjects, ensuring that many spontaneous mutations occur every generation and that adaptive variants can spread rapidly through a population. Another highly useful experimental feature is the ability to preserve and store ancestral and evolutionarily derived clones. These can be revived in parallel to allow the direct measurement of the competitive fitness of a descendant compared with its ancestor. The extent of adaptation can thereby be measured quantitatively and compared statistically by direct competition among derived groups and with the ancestor. Thus, fitness and adaptation need not be matters of qualitative speculation, but are quantitatively measurable variables in these systems. Replication allows the quantification of heterogeneity in responses to imposed selection and thereby statistical distinction between changes that are systematic responses to the selective regimen and those that are specific to individual populations.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Computational models are well-suited to study evolutionary change on the population level, whereas in silico evolution of artificial cells that include simulated regulatory networks is currently very limited.
“Computational models are well-suited to study evolutionary change on the population level, whereas in silico evolution of artificial cells that include simulated regulatory networks are currently very limited [21].”
From Adaptive laboratory evolution—Principles and applications for biotechnology (2013) · cites this paper as [21]
Cites
Textbook of Medical Physiology
Guyton, A. C., & Hall, J. E. (1966) · Annals of Internal Medicine · doi:10.7326/0003-4819-64-6-1363_2 · Cited by 9,760 · see citing works
Evolution in Changing Environments
Levins, R. (1968) · Princeton University Press eBooks · doi:10.1515/9780691209418 · Cited by 5,395 · see citing works
Fisher, R. A. (1936) · BMJ · doi:10.1136/bmj.1.3923.554-a · Cited by 4,980 · see citing works
Evolution in Changing Environments
Levins, R. (2020) · Princeton University Press eBooks · doi:10.2307/j.ctvx5wbbh · Cited by 3,405 · see citing works
Platt, J. R. (1964) · Science · doi:10.1126/science.146.3642.347 · Cited by 2,907 · see citing works
Wonderful Life: The Burgess Shale and the Nature of History
Gould, S. (1989) · Choice Reviews Online · doi:10.5860/choice.27-3873 · Cited by 2,168 · see citing works
Hochachka, P. W., & Somero, G. N. (2002) · doi:10.1093/oso/9780195117028.001.0001 · Cited by 1,935 · see citing works
Genetics and Evolution of Phenotypic Plasticity
Scheiner, S. M. (1993) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.es.24.110193.000343 · Cited by 1,824 · see citing works
Lenski, R. E., Rose, M. R., Simpson, S. C., & Tadler, S. C. (1991) · The American Naturalist · doi:10.1086/285289 · Cited by 1,582 · see citing works
Biochemical Adaptation: Mechanism and Process in Physiological Evolution
Hochachka, P. W., & Somero, G. N. (1984) · Cited by 1,500 · see citing works
Benedict, K. M., Reses, H. E., Vigar, M. K., Roth, D. M., Roberts, V. A., Mattioli, M. C. M., Cooley, L. A., Hilborn, E. D., Wade, T. J., Fullerton, K. E., et al. (2017) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6644a3 · Cited by 882 · see citing works
Behavioral Drive versus Behavioral Inertia in Evolution: A Null Model Approach
Huey, R. B., Hertz, P., & Sinervo, B. (2003) · The American Naturalist · doi:10.1086/346135 · Cited by 807 · see citing works
Upper Gastrointestinal (GI) pH in Young, Healthy Men and Women
Dressman, J., Berardi, R. R., Dermentzoglou, L. C., Russell, T. L., Schmaltz, S. P., Barnett, J. L., & Jarvenpaa, K. M. (1990) · Pharmaceutical Research · doi:10.1023/a:1015827908309 · Cited by 784 · see citing works
Gasparini, M., & Rogantin, M. P. (2008) · PORTO Publications Open Repository TOrino (Politecnico di Torino) · Cited by 383 · see citing works
Exceptional Convergent Evolution in a Virus
Bull, J. J., Badgett, M. R., Wichman, H. A., Huelsenbeck, J. P., Hillis, D. M., Gulati, A., Ho, C., & Molineux, I. J. (1997) · Genetics · doi:10.1093/genetics/147.4.1497 · Cited by 375 · see citing works
Upper Gastrointestinal pH in Seventy-Nine Healthy, Elderly, North American Men and Women
Russell, T. L., Berardi, R. R., Barnett, J. L., Dermentzoglou, L. C., Jarvenpaa, K. M., Schmaltz, S. P., & Dressman, J. (1993) · Pharmaceutical Research · doi:10.1023/a:1018970323716 · Cited by 370 · see citing works
Thermal Acclimation and Heat Resistance in Drosophila Species
Levins, R. (1969) · American Naturalist · doi:10.1086/282616 · Cited by 365 · see citing works
Dallinger, W. H. (1888) · Journal of the Royal Microscopical Society · doi:10.1111/j.1365-2818.1888.tb01685.x · Cited by 331 · see citing works
Leroi, A. M., Bennett, A. F., & Lenski, R. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.5.1917 · Cited by 322 · see citing works
Self-citationPhenotypic plasticity and experimental evolution
Garland, T., & Kelly, S. A. (2006) · Journal of Experimental Biology · doi:10.1242/jeb.02244 · Cited by 319 · see citing works
Tests of parallel molecular evolution in a long-term experiment with Escherichia coli
Woods, R. J., Schneider, D., Winkworth, C. L., Riley, M. A., & Lenski, R. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602917103 · Cited by 316 · see citing works
Escherichia coli Habitats, Cell Types, and Molecular Mechanisms of Gene Control
Savageau, M. A. (1983) · The American Naturalist · doi:10.1086/284168 · Cited by 315 · see citing works
Krogh, A. (1929) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1929.90.2.243 · Cited by 299 · see citing works
Clarkston, W., Pantano, M., Morley, J. E., Horowitz, M., Littlefield, J. M., & Burton, F. R. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.1.r243 · Cited by 297 · see citing works
An experimental test of evolutionary trade-offs during temperature adaptation
Bennett, A. F., & Lenski, R. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702117104 · Cited by 285 · see citing works
Self-citationBreaking through the acid barrier: An orchestrated response to proton stress by enteric bacteria
Audia, J. P., Webb, C. C., & Foster, J. W. (2001) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00106 · Cited by 258 · see citing works
Bennett, A. F., Lenski, R. E., & Mittler, J. E. (1992) · Evolution · doi:10.1111/j.1558-5646.1992.tb01981.x · Cited by 244 · see citing works
Self-citationExperimental Studies of Natural Selection in Bacteria
Dykhuizen, D. E. (1990) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.es.21.110190.002105 · Cited by 229 · see citing works
EVOLUTIONARY ADAPTATION TO TEMPERATURE II. THERMAL NICHES OF EXPERIMENTAL LINES OF ESCHERICHIA COLI
Bennett, A. F., & Lenski, R. E. (1993) · Evolution · doi:10.1111/j.1558-5646.1993.tb01194.x · Cited by 204 · see citing works
Self-citationCampylobacter jejuni non-culturable coccoid cells
Beumer, R. R., de Vries, J., & ROMBOUTS, F. M. (1992) · International Journal of Food Microbiology · doi:10.1016/0168-1605(92)90144-r · Cited by 203 · see citing works
Adaptational biology; molecules to organisms
(1987) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(87)90643-8 · Cited by 185 · see citing works
Rapid evolution in response to high-temperature selection
Bennett, A. F., Dao, K. M., & Lenski, R. E. (1990) · Nature · doi:10.1038/346079a0 · Cited by 182 · see citing works
Self-citationDziuban, E. J., Liang, J. L., Craun, G. F., Hill, V. R., Yu, P. A., Painter, J. E., Moore, M. R., Calderon, R. L., Roy, S. L., & Beach, M. J. (2006) · PubMed · Cited by 150 · see citing works
Lenski, R. E., Winkworth, C. L., & Riley, M. A. (2003) · Journal of Molecular Evolution · doi:10.1007/s00239-002-2423-0 · Cited by 131 · see citing works
Thermal Acclimation of Metabolism in Sceloporus Lizards from Different Latitudes
Tsuji, J. S. (1988) · Physiological Zoology · doi:10.1086/physzool.61.3.30161237 · Cited by 122 · see citing works
Storm effects on regional beach water quality along the southern California shoreline
Noble, R. T., Weisberg, S. B., Leecaster, M. K., McGee, C. D., Dorsey, J. H., Vainik, P. M., & Orozco-Borbón, V. (2003) · Journal of Water and Health · doi:10.2166/wh.2003.0004 · Cited by 122 · see citing works
Terblanche, J. S., & Chown, S. L. (2006) · Journal of Experimental Biology · doi:10.1242/jeb.02129 · Cited by 120 · see citing works
Evolutionary genomics of ecological specialization
Zhong, S., Khodursky, A. B., Dykhuizen, D. E., & Dean, A. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404397101 · Cited by 112 · see citing works
Coastal water quality impact of stormwater runoff from an urban watershed in southern California.
Ahn, J., Grant, S., Surbeck, C., DiGiacomo, P., Nezlin, N., & Jiang, S. C. (2005) · Environmental Science and Technology · doi:10.1021/es0501464 · Cited by 111 · see citing works
Environmental Variability and Thermal Acclimation in Neotropical and Temperate Zone Salamanders
Feder, M. E. (1978) · Physiological Zoology · doi:10.1086/physzool.51.1.30158660 · Cited by 91 · see citing works
Experimental evolution: experimental evolution and evolvability
Colegrave, N., & Collins, S. (2008) · Heredity · doi:10.1038/sj.hdy.6801095 · Cited by 91 · see citing works
Bennett, A. F., & Lenski, R. E. (1997) · Evolution · doi:10.1111/j.1558-5646.1997.tb02386.x · Cited by 90 · see citing works
Self-citationThe Reverend Dr William Henry Dallinger, F.R.S. (1839-1909)
Hass, J. (2000) · Notes and Records the Royal Society Journal of the History of Science · doi:10.1098/rsnr.2000.0096 · Cited by 83 · see citing works
Survival and activity of Salmonella typhimurium and Escherichia coli in tropical freshwater
Jiménez, L., Muñiz, I., Toranzos, G. A., & Hazen, T. C. (1989) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1989.tb04955.x · Cited by 82 · see citing works
Ostrowski, E. A., Woods, R. J., & Lenski, R. E. (2007) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2007.1244 · Cited by 73 · see citing works
EVOLUTIONARY ADAPTATION TO ENVIRONMENTAL pH IN EXPERIMENTAL LINEAGES OF ESCHERICHIA COLI
Hughes, B. S., Cullum, A. J., & Bennett, A. F. (2007) · Evolution · doi:10.1111/j.1558-5646.2007.00139.x · Cited by 71 · see citing works
Self-citationDallinger, W. H. (1887) · Journal of the Royal Microscopical Society · doi:10.1111/j.1365-2818.1887.tb01566.x · Cited by 68 · see citing works
Leroi, A. M., Lenski, R. E., & Bennett, A. F. (1994) · Evolution · doi:10.1111/j.1558-5646.1994.tb05307.x · Cited by 60 · see citing works
Self-citationBennett, A. F. (2003) · Physiological and Biochemical Zoology · doi:10.1086/374275 · Cited by 56 · see citing works
Self-citationAn Experimental Evolutionary Study on Adaptation to Temporally Fluctuating pH inEscherichia coli
Hughes, B. S., Cullum, A. J., & Bennett, A. F. (2007) · Physiological and Biochemical Zoology · doi:10.1086/518353 · Cited by 54 · see citing works
Self-citationStrange, K. B. (2007) · Journal of Experimental Biology · doi:10.1242/jeb.000125 · Cited by 36 · see citing works
Watson, M., & Hoffmann, A. A. (1995) · Australian Journal of Zoology · doi:10.1071/zo9950051 · Cited by 35 · see citing works
Inactivation of Escherichia coli O157:H7 in Simulated Human Gastric Fluid
Tamplin, M. L. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.1.320-325.2005 · Cited by 32 · see citing works
Naugle, A. L., Holt, K. G., Levine, P., & Eckel, R. (2006) · Journal of Food Protection · doi:10.4315/0362-028x-69.3.480 · Cited by 13 · see citing works
Hughes, B. (2008) · Aquatic Microbial Ecology · doi:10.3354/ame01246 · Cited by 5 · see citing works
Self-citationDifferential Patterns of Gene Expression and Gene Complement in Laboratory-Evolved Lines of E. coli
Riehle, M. M. (2005) · Integrative and Comparative Biology · doi:10.1093/icb/45.3.532 · Cited by 5 · see citing works
Flagged first, then by citations
1 of the 57 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Adaptive laboratory evolution—Principles and applications for biotechnology
Dragosits, M., & Mattanovich, D. (2013) · Microbial Cell Factories · doi:10.1186/1475-2859-12-64 · Cited by 827 · see citing works
Sandberg, T. E., Salazar, M. J., Weng, L. L., Palsson, B. Ø., & Feist, A. M. (2019) · Metabolic Engineering · doi:10.1016/j.ymben.2019.08.004 · Cited by 558 · see citing works
Adaptive laboratory evolution principles and applications in industrial biotechnology
Mavrommati, M., Daskalaki, A., Papanikolaou, S., & Aggelis, G. (2021) · Biotechnology Advances · doi:10.1016/j.biotechadv.2021.107795 · Cited by 269 · see citing works
Experimental Measures of Pathogen Competition and Relative Fitness
Zhan, J., & McDonald, B. A. (2013) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-082712-102302 · Cited by 147 · see citing works
Current Status and Applications of Adaptive Laboratory Evolution in Industrial Microorganisms
Lee, S., & Kim, P. (2020) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2003.03072 · Cited by 127 · see citing works
The functional basis of adaptive evolution in chemostats
Gresham, D., & Hong, J. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12082 · Cited by 122 · see citing works
Advanced strategies and tools to facilitate and streamline microbial adaptive laboratory evolution
Wu, Y., Jameel, A., Xing, X., & Zhang, C. (2021) · Trends in biotechnology · doi:10.1016/j.tibtech.2021.04.002 · Cited by 111 · see citing works
Experimental Evolution as an Underutilized Tool for Studying Beneficial Animal–Microbe Interactions
Hoang, K. L., Morran, L. T., & Gerardo, N. M. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01444 · Cited by 58 · see citing works
Mavrommati, M., Papanikolaou, S., & Aggelis, G. (2022) · Process Biochemistry · doi:10.1016/j.procbio.2022.11.027 · Cited by 57 · see citing works
Webber, M. K., & Samaras, C. (2022) · Earth s Future · doi:10.1029/2021ef002322 · Cited by 50 · see citing works
Adaptation to fluctuations in temperature by nine species of bacteria
Saarinen, K., Laakso, J. T., Lindström, L., & Ketola, T. (2018) · Ecology and Evolution · doi:10.1002/ece3.3823 · Cited by 48 · see citing works
Selecting the Best: Evolutionary Engineering of Chemical Production in Microbes
Shepelin, D., Hansen, A. S. L., Lennen, R. M., Luo, H., & Herrgård, M. J. (2018) · Genes · doi:10.3390/genes9050249 · Cited by 43 · see citing works
Towards Integrating Evolution, Metabolism, and Climate Change Studies of Marine Ecosystems
Baltar, F., Bayer, B., Bednaršek, N., Deppeler, S., Escribano, R., González, C. E., Hansman, R. L., Mishra, R. K., Moran, M. A., Repeta, D. J., et al. (2019) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2019.07.003 · Cited by 42 · see citing works
Fernandes, T., Osório, C., Sousa, M. J., & Franco‐Duarte, R. (2023) · Journal of Fungi · doi:10.3390/jof9020186 · Cited by 41 · see citing works
Yu, Z., Krause, S., Beck, D. A. C., & Chistoserdova, L. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00946 · Cited by 40 · see citing works
McCarthy, S., Johnson, T. B., Pavlik, B. J., Payne, S., Schackwitz, W., Martin, J., Lipzen, A., Keffeler, E. C., & Blum, P. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.03225-15 · Cited by 37 · see citing works
Soto, W., Punke, E. B., & Nishiguchi, M. K. (2011) · Evolution · doi:10.1111/j.1558-5646.2011.01547.x · Cited by 34 · see citing works
Adaptively evolved yeast mutants on galactose show trade-offs in carbon utilization on glucose
Hong, K.-K., & Nielsen, J. (2013) · Metabolic Engineering · doi:10.1016/j.ymben.2013.01.007 · Cited by 33 · see citing works
Malmendal, A., Sørensen, J. G., Overgaard, J., Holmstrup, M., Nielsen, N. C., & Loeschcke, V. (2013) · Die Naturwissenschaften · doi:10.1007/s00114-013-1040-7 · Cited by 32 · see citing works
Experimental evolution: its principles and applications in developing stress-tolerant yeasts
Swamy, K. B. S., & Zhou, N. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-09616-2 · Cited by 24 · see citing works
Adaptation and Heterogeneity of Escherichia coli MC1000 Growing in Complex Environments
Puentes‐Téllez, P. E., Hansen, M. A., Sørensen, S. J., & van Elsas, J. D. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.02920-12 · Cited by 20 · see citing works
Guyot, S., Pottier, L., Hartmann, A., Ragon, M., Tiburski, J. H., Molin, P., Ferret, É., & Gervais, P. (2013) · MicrobiologyOpen · doi:10.1002/mbo3.146 · Cited by 20 · see citing works
Harwani, D., Begani, J., Barupal, S., & Lakhani, J. (2022) · Journal of Genetic Engineering and Biotechnology · doi:10.1186/s43141-021-00283-3 · Cited by 18 · see citing works
McCarthy, S., Ai, C., & Blum, P. (2018) · Advances in applied microbiology · doi:10.1016/bs.aambs.2018.03.002 · Cited by 17 · see citing works
Using colony size to measure fitness in Saccharomyces cerevisiae
Miller, J. H., Fasanello, V. J., Liu, P., Longan, E. R., Botero, C. A., & Fay, J. C. (2022) · PLoS ONE · doi:10.1371/journal.pone.0271709 · Cited by 16 · see citing works
Lee, J., Kim, D.-Y., & Kim, M. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112665 · Cited by 16 · see citing works
Nahid, M. A., Griffin, J. M., Lustik, M. B., Hayes, J. J., Fong, K. S. K., Horseman, T. S., Menguito, M., Snesrud, E. C., Barnhill, J. C., & Washington, M. A. (2021) · Infection and Drug Resistance · doi:10.2147/idr.s260708 · Cited by 13 · see citing works
Semumu, T., Gamero, A., Boekhout, T., & Zhou, N. (2022) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-021-03226-9 · Cited by 11 · see citing works
Karve, S. M., & Wagner, A. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msab341 · Cited by 10 · see citing works
Pearless, S. M., & Freed, N. E. (2024) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2024.1335452 · Cited by 10 · see citing works
Experimental Microbial Evolution of Extremophiles
Blum, P., Rudrappa, D., Singh, R., McCarthy, S., & Pavlik, B. J. (2016) · Grand challenges in biology and biotechnology · doi:10.1007/978-3-319-13521-2_22 · Cited by 8 · see citing works
Li, J., Tao, W., Yue, S., Yuan, Z., & Li, S. (2023) · Fermentation · doi:10.3390/fermentation9060525 · Cited by 7 · see citing works
Mavrommati, M., Economou, C. Ν., Καλλιθράκα, Σ., Papanikolaou, S., & Aggelis, G. (2024) · Carbon Resources Conversion · doi:10.1016/j.crcon.2024.100270 · Cited by 6 · see citing works
Medici, V., Vonesch, S. C., Fry, S. N., & Hafen, E. (2015) · G3 Genes Genomes Genetics · doi:10.1534/g3.114.013664 · Cited by 6 · see citing works
Han, Z., Sun, Z., Liu, X., Zhen, D., Guo, Q., Zheng, L., Jiang, S., Zhang, Z., Shen, S., & Zhang, J. (2026) · Nature Communications · doi:10.1038/s41467-026-69823-0 · Cited by 4 · see citing works
Sabra, S. M. M. (2018) · Journal of Applied Biotechnology & Bioengineering · doi:10.15406/jabb.2018.05.00160 · Cited by 4 · see citing works
Wang, P., Driscoll, W. W., & Travisano, M. (2024) · Communications Biology · doi:10.1038/s42003-024-06485-y · Cited by 3 · see citing works
Genomic Pipeline for Analysis of Mutational Events in Bacteria
Lemée, P., Charron, R., & Bridier, A. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-4100-2_15 · Cited by 3 · see citing works
A Reproduction and Replication of Engel's Meta-Study of Dictator Game ExperimentsPreprint
Zhang, L., & Ortmann, A. (2012) · SSRN Electronic Journal · doi:10.2139/ssrn.2171064 · Cited by 3 · see citing works
Microbial Evolution in the Chemostat
Arkin, S. S. (2010) · OpenGrey (Institut de l'Information Scientifique et Technique) · doi:10.13140/rg.2.1.2580.2325 · Cited by 3 · see citing works
Engineering of Zymomonas mobilis for Enhanced Biofuel Production
Khalid, M., Rubab, N., Afzal, W., Irfan, M. I., Ghazanfar, M., Shakir, H. A., Khan, M. B., Ali, S., & Franco, M. (2021) · Clean Energy Production Technologies · doi:10.1007/978-981-33-4611-6_6 · Cited by 2 · see citing works
Environmental Fluctuations Drive Species' Competitive Success in Experimental Invasions
Räsänen, E., Lindström, L., & Ketola, T. (2020) · Annales Zoologici Fennici · doi:10.5735/086.057.0109 · Cited by 2 · see citing works
Muñoz-Laiton, P., Hernández-Valencia, J. C., Isaza, J. P., & Correa, M. M. (2025) · Acta Tropica · doi:10.1016/j.actatropica.2025.107795 · Cited by 1 · see citing works
Adaptive Laboratory Evolution of Pichia pastoris by Serial Batch Cultivation
Moritz, C., Gassler, T., Altvater, M., & Mattanovich, D. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4779-0_26 · Cited by 1 · see citing works
The evolution of temperature tolerance and invasiveness in a fluctuating thermal environment
Saarinen, K. (2016) · Jyväskylä University Digital Archive (University of Jyväskylä) · Cited by 1 · see citing works
Mavrommati, M., Economou, C. Ν., Καλλιθράκα, Σ., Papanikolaou, S., & Aggelis, G. (2023) · Research Square · doi:10.21203/rs.3.rs-3035985/v1 · Cited by 1 · see citing works
Repeatability of the Adaptation of Pseudomonas fluorescens to Low Glucose
Teselkin, O. (2014) · uO Research (University of Ottawa) · doi:10.20381/ruor-3686
Adaptation and diversification of Escherichia coli K12 MC1000 in a complex environment
Puentes‐Téllez, P. E. (2014) · University of Groningen research database (University of Groningen / Centre for Information Technology)
McCarthy, S., Johnson, T. B., Pavlik, B. J., Payne, S., Schackwitz, W., Martin, J., Lipzen, A., Keffeler, E. C., & Blum, P. (2016) · eScholarship (California Digital Library)
Microbial lifestyle engineering
Kampers, L. F. C. (2020) · doi:10.18174/516082
Temperature stress disrupts reciprocal adaptation in a microbial predator-prey system
Plum, K., & Zufall, R. A. (2026) · Journal of Evolutionary Biology · doi:10.1093/jeb/voag018
Houtak, G., Monk, I. R., Awad, M., Nepal, R., Ramezanpour, M., Psaltis, A. J., Wormald, P., Bouras, G. S., Stinear, T. P., & Vreugde, S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.30.735446
Zhang, J., Cotrina, S., Benito, B., Bañuelos, M. A., González, C., & Morata, A. (2026) · LWT · doi:10.1016/j.lwt.2026.119757
Hartono, S., Røder, H. L., Boeren, S. A., Swarts, D. C., Abee, T., Smid, E. J., & van Mastrigt, O. (2026) · Microbiological Research · doi:10.1016/j.micres.2026.128706
- Authors
- Bennett, A. F., & Hughes, B. S.
- Affiliations
- University of California, Irvine (US)
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2009-07
- Volume
- 297
- Issue
- 1
- Pages
- R17-R25
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2148332466
- Cited by
- 58
- References
- 57
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 6 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Social Sciences › Cultural Studies › Language and cultural evolution
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy and History of Science
- Keywords
- experimental evolution, population genetics, fitness measurement, adaptation, competitive fitness, parallel evolution, replication, spontaneous mutation
- MeSH terms
- Adaptation, Physiological, Environment, Gene Expression Regulation, Genetics, Microbial, Genotype, Hydrogen-Ion Concentration, Microbiological Techniques, Mutation, Phenotype, Population Density, Reproduction, Selection, Genetic, Time Factors, Reproducibility of Results, Cryopreservation, Evolution, Molecular, Biomedical Research
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
