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Cited by 71

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Glucagon-like peptide-1 receptor stimulation increases GFR and suppresses proximal reabsorption in the rat

Thomson, Scott C., Kashkouli, Ali, Singh, Prabhleen·2013·American Journal of Physiology-Renal Physiology
DOI 10.1152/ajprenal.00064.2012
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Abstract

The incretin hormone glucagon-like peptide-1 (GLP-1) is released from the gut in response to fat or carbohydrate and contributes to negative feedback control of blood glucose by stimulating insulin secretion, inhibiting glucagon, and slowing gastric emptying. GLP-1 receptors (GLP-1R) are also expressed in the proximal tubule, and possibly elsewhere in the kidney. Presently, we examined the effect of a GLP-1R agonist on single-nephron glomerular filtration rate (GFR; SNGFR), proximal reabsorption ( Jprox), tubuloglomerular feedback (TGF) responses, and urine flow rate in hydropenic male Wistar and Wistar-Froemter rats. Micropuncture and whole-kidney data were obtained before and during infusion of the GLP-1 agonist exenatide (1 nmol/h iv). SNGFR and Jprox were measured by late proximal collection at both extremes of TGF activation, which was achieved by perfusing Henle's loop at 0 or 50 nl/min. Primary changes in Jprox were revealed by analysis of covariance for Jprox with SNGFR as a covariate. Effects on TGF activation were determined in a separate set of experiments by comparing early distal and late proximal collections. Exenatide increased SNGFR by 33–50%, suppressed proximal tubular reabsorption by 20–40%, doubled early distal flow rate, and increased urine flow rate sixfold without altering the efficiency of glomerulotubular balance, TGF responsiveness, or the tonic influence of TGF. This implies that exenatide is both a proximal diuretic and a renal vasodilator. Since the natural agonist for the GLP-1R is regulated by intake of fat and carbohydrate, but not by salt or fluid, the control of salt excretion by the GLP-1R system departs from the usual negative-feedback paradigm for regulating salt balance.

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Research works printed but not linked: 2

  1. 10.1210/endo.139.9.6202 · doi:10.1210/endo.139.9.6202 · Paper page
  2. Thomson SC, 1997, Am J Physiol Renal Physiol, 273, F1414

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Metadata

Authors
Thomson, S. C., Kashkouli, A., & Singh, P.
Affiliations
Department of Medicine, University of California and Veterans Affairs San Diego Healthcare System, San Diego, California
Venue
American Journal of Physiology-Renal Physiology
Publisher
American Physiological Society
Published
2013-01-15
Volume
304
Issue
2
Pages
F137-F144
ISSN
  • 1931-857X
  • 1522-1466
DOI
10.1152/ajprenal.00064.2012
Cited by
71
References
37
Language
en

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CoChat. (2026). Citation check: Glucagon-like peptide-1 receptor stimulation increases GFR and suppresses proximal reabsorption in the rat. https://app.cochat.ai/papers/10.1152/ajprenal.00064.2012
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Thomson, S. C., Kashkouli, A., & Singh, P. (2013). Glucagon-like peptide-1 receptor stimulation increases GFR and suppresses proximal reabsorption in the rat. American Journal of Physiology-Renal Physiology. https://doi.org/10.1152/ajprenal.00064.2012

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