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Perfluoroalkyl Substances (PFASs) Are Substrates of the Renal Human Organic Anion Transporter 4 (OAT4)

Louisse, J., Dellafiora, L., van den Heuvel, J. J. M. W., Rijkers, D., Leenders, L., Dorne, J.-L. C. M., Punt, A., Russel, F. G. M., & Koenderink, J. B. (2023) · Archives of Toxicology · doi:10.1007/s00204-022-03428-6 · Cited by 84 · see citing works

A food web bioaccumulation model for the accumulation of per- and polyfluoroalkyl substances (PFAS) in fish: how important is renal elimination?

Sun, J., Kelly, B. C., Gobas, F. A. P. C., & Sunderland, E. M. (2022) · Environmental Science Processes & Impacts · doi:10.1039/d2em00047d · Cited by 85 · see citing works

Bioavailability of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) in biosolids-amended soils to earthworms (Eisenia fetida)

Wen, B., Zhang, H., Li, L., Hu, X., Liu, Y., Shan, X.-Q., & Zhang, S. (2014) · Chemosphere · doi:10.1016/j.chemosphere.2014.08.009 · Cited by 83 · see citing works

A Permeability-Limited Physiologically Based Pharmacokinetic (PBPK) Model for Perfluorooctanoic acid (PFOA) in Male Rats

Cheng, W., & Ng, C. A. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b02602 · Cited by 83 · see citing works

Perfluoroalkyl substances and thyroid function in older adults

Shrestha, S., Bloom, M. S., Yucel, R., Seegal, R. F., Wu, Q., Kannan, K., Rej, R., & Fitzgerald, E. F. (2015) · Environment International · doi:10.1016/j.envint.2014.11.018 · Cited by 76 · see citing works

Exposure to perfluoroalkyl substances in waste recycling workers: Distributions in paired human serum and urine

Peng, L., Wang, X., Zeng, Q., Sun, F., Guo, Y., Zhong, S., Wang, F., & Chen, D. (2021) · Environment International · doi:10.1016/j.envint.2021.106963 · Cited by 75 · see citing works

Fluorotechnology Is Critical to Modern Life: The FluoroCouncil Counterpoint to the Madrid Statement

Bowman, J. S. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1509910 · Cited by 75 · see citing works

Perfluoroalkyl substances follow inverted U-shaped distributions across various stages of glomerular function: Implications for future research

Jain, R. B., & DUCATMAN, A. M. (2018) · Environmental Research · doi:10.1016/j.envres.2018.11.033 · Cited by 73 · see citing works

Perfluoroalkyl substances and cognitive function in older adults: Should we consider non-monotonic dose-responses and chronic kidney disease?

Park, S. K., Ding, N., & Han, D. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110346 · Cited by 68 · see citing works

Longitudinal trends of per- and polyfluoroalkyl substances in children's serum

Koponen, J. M., Winkens, K., Airaksinen, R., Berger, U., Vestergren, R., Cousins, I. T., Karvonen, A. M., Pekkanen, J., & Kiviranta, H. (2018) · Environment International · doi:10.1016/j.envint.2018.09.006 · Cited by 66 · see citing works

Association between maternal exposure to perfluoroalkyl and polyfluoroalkyl substances and risks of adverse pregnancy outcomes: A systematic review and meta-analysis

Deji, Z., Liu, P., Wang, X., Zhang, X., Luo, Y., & Huang, Z. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.146984 · Cited by 64 · see citing works

Novel Insights into the Adverse Health Effects of per- and Polyfluoroalkyl Substances on the Kidney via Human Urine Metabolomics

He, A., Li, J., Zhao, L., Lu, Y., Liang, Y., Zhou, Z., Man, Z., Lv, J., Wang, Y., & Jiang, G. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c06480 · Cited by 65 · see citing works

Perfluorohexanoic acid toxicity, part I: Development of a chronic human health toxicity value for use in risk assessment

Luz, A. L., Anderson, J. K., Goodrum, P., & Durda, J. (2019) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2019.01.019 · Cited by 63 · see citing works

Effects of chronic perfluorooctanoic acid (PFOA) at low concentration on morphometrics, gene expression, and fecundity in zebrafish (Danio rerio)

Jantzen, C. E., Toor, F., Annunziato, K. A., & Cooper, K. R. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2017.01.009 · Cited by 61 · see citing works

The Need for Testing Isomer Profiles of Perfluoroalkyl Substances to Evaluate Treatment Processes

Londhe, K., Lee, C., McDonough, C. A., & Venkatesan, A. K. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c05518 · Cited by 64 · see citing works

Temporal trends of concentrations of per- and polyfluoroalkyl substances among adults with overweight and obesity in the United States: Results from the Diabetes Prevention Program and NHANES

Lin, P. D., Cárdenas, A., Hauser, R. B., Gold, D. R., KLEINMAN, K. P., Hivert, M., Calafat, A. M., Webster, T. F., Horton, E. S., & Oken, E. (2021) · Environment International · doi:10.1016/j.envint.2021.106789 · Cited by 60 · see citing works

Absorption and Excretion of 14 C-Perfluorooctanoic Acid (PFOA) in Angus Cattle (Bos taurus)

Lupton, S. J., Huwe, J. K., Smith, D. J., Dearfield, K. L., & Johnston, J. J. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2042505 · Cited by 60 · see citing works

A transgenerational toxicokinetic model and its use in derivation of Minnesota PFOA water guidance

Goeden, H. M., Greene, C. W., & Jacobus, J. A. (2019) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-018-0110-5 · Cited by 59 · see citing works

Serum concentrations of perfluorinated alkyl substances in farmers living in areas affected by water contamination in the Veneto Region (Northern Italy)

Ingelido, A. M., Abballe, A., Gemma, S., Dellatte, E., Iacovella, N., Angelis, G. D., Marra, V., Russo, F., Vazzoler, M., Testai, E., et al. (2020) · Environment International · doi:10.1016/j.envint.2019.105435 · Cited by 59 · see citing works

Perfluorooctanoic acid (PFOA) exposure in relation to the kidneys: A review of current available literature

Liu, D., Yan, S., Wang, P., Chen, Q., Liu, Y., Cui, J., Liang, Y., Ren, S., & Gao, Y. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1103141 · Cited by 61 · see citing works

Development and Evaluation of Aquatic and Terrestrial Food Web Bioaccumulation Models for Per- and Polyfluoroalkyl Substances

Kelly, B. C., Sun, J. M., McDougall, M. R. R., Sunderland, E. M., & Gobas, F. A. P. C. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.4c02134 · Cited by 61 · see citing works

Evaluation of 14 PFAS for permeability and organic anion transporter interactions: Implications for renal clearance in humans

Ryu, S., Yamaguchi, E., Modaresi, S. M. S., Agudelo, J., Costales, C., West, M. A., Fischer, F. C., & Slitt, A. L. (2024) · Chemosphere · doi:10.1016/j.chemosphere.2024.142390 · Cited by 57 · see citing works

Physiologically based pharmacokinetic modeling of human exposure to perfluorooctanoic acid suggests historical non drinking-water exposures are important for predicting current serum concentrations

Worley, R., Yang, X.-X., & Fisher, J. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.07.001 · Cited by 51 · see citing works

Impact of perfluorochemicals on human health and reproduction: a male’s perspective

Foresta, C., Tescari, S., & Nisio, A. D. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0790-z · Cited by 57 · see citing works

A machine learning model to estimate toxicokinetic half-lives of per- and polyfluoro-alkyl substances (PFAS) in multiple species

Dawson, D. E., Lau, C., Pradeep, P., Sayre, R. R., Judson, R. S., Tornero-Velez, R., & Wambaugh, J. F. (2023) · Toxics · doi:10.3390/toxics11020098 · Cited by 56 · see citing works

Perfluoroalkyl acids, hyperuricemia and gout in adults: Analyses of NHANES 2009–2014

Scinicariello, F., Buser, M. C., Balluz, L. S., Gehle, K., Murray, H., Abadin, H. G., & Attanasio, R. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.127446 · Cited by 55 · see citing works

Effects of per- and polyfluoroalkyl substances on the liver: Human-relevant mechanisms of toxicity

Maerten, A., Callewaert, E., Sanz-Serrano, J., Devisscher, L., & Vinken, M. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.176717 · Cited by 54 · see citing works

How the Structure of Per- and Polyfluoroalkyl Substances (PFAS) Influences Their Binding Potency to the Peroxisome Proliferator-Activated and Thyroid Hormone Receptors—An In Silico Screening Study

Kowalska, D., Sosnowska, A., Buławska, N., Stepnik, M., Behnisch, P., Behnisch, P., & Puzyn, T. (2023) · Molecules · doi:10.3390/molecules28020479 · Cited by 53 · see citing works

Stochastic Pharmacokinetic-Pharmacodynamic Modeling for Assessing the Systemic Health Risk of Perfluorooctanoate (PFOA)

Convertino, M., Church, T. R., Olsen, G. W., Liu, Y., Doyle, E., Elcombe, C. R., Barnett, A. L., Samuel, L. M., Macpherson, I. R., & Evans, T. R. J. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy035 · Cited by 54 · see citing works

Exploring sex differences in human health risk assessment for PFNA and PFDA using a PBPK model

Kim, S., Choi, E.-J., Choi, G.-W., Lee, Y., & Cho, H. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2365-y · Cited by 53 · see citing works

Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling

Sakolish, C., Chen, Z., Dalaijamts, C., Mitra, K., Liu, Y., Fulton, T., Wade, T. L., Kelly, E. J., Rusyn, I., & Chiu, W. A. (2019) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.104752 · Cited by 53 · see citing works

Contribution of Direct and Indirect Exposure to Human Serum Concentrations of Perfluorooctanoic Acid in an Occupationally Exposed Group of Ski Waxers.

Gomis, M. I., Vestergren, R., Nilsson, H., & Cousins, I. (2016) · Environmental Science and Technology · doi:10.1021/acs.est.6b01477 · Cited by 46 · see citing works

Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes

Marques, E., Pfohl, M., Wei, W., Tarantola, G., Ford, L. C., Amaeze, O. U., Alesio, J., Ryu, S., Jia, X., Zhu, H., et al. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.115991 · Cited by 51 · see citing works

Development of a Gestational and Lactational Physiologically Based Pharmacokinetic (PBPK) Model for Perfluorooctane Sulfonate (PFOS) in Rats and Humans and Its Implications in the Derivation of Health-Based Toxicity Values

Chou, W., & Lin, Z. (2021) · Environmental Health Perspectives · doi:10.1289/ehp7671 · Cited by 50 · see citing works

Kinetics of 15 per- and polyfluoroalkyl substances (PFAS) after single oral application as a mixture – A pilot investigation in a male volunteer

Abraham, K., Mertens, H., Richter, L., Mielke, H., Schwerdtle, T., & Monien, B. H. (2024) · Environment International · doi:10.1016/j.envint.2024.109047 · Cited by 52 · see citing works

Repeated dose and reproductive/developmental toxicity of perfluoroundecanoic acid in rats

Takahashi, M., Ishida, S., Hirata‐Koizumi, M., Ono, A., & Hirose, A. (2014) · The Journal of Toxicological Sciences · doi:10.2131/jts.39.97 · Cited by 49 · see citing works

Exposure to per- and polyfluoroalkyl substances through the consumption of fish from lakes affected by aqueous film-forming foam emissions — A combined epidemiological and exposure modeling approach. The SAMINOR 2 Clinical Study

Hansen, S., Vestergren, R., Herzke, D., Melhus, M., Evenset, A., Hanssen, L., Brustad, M., & Sandanger, T. M. (2016) · Environment International · doi:10.1016/j.envint.2016.05.030 · Cited by 47 · see citing works

Per- and polyfluoroalkyl substances and male reproductive health: a systematic review of the epidemiological evidence

Petersen, K. U., Larsen, J., Deen, L., Flachs, E. M., Hærvig, K. K., Hull, S. D., Bonde, J. P., & Tøttenborg, S. S. (2020) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2020.1798315 · Cited by 45 · see citing works

Breaking It Down: Estimating Short-Chain PFAS Half-Lives in a Human Population

Nicole, W. (2020) · Environmental Health Perspectives · doi:10.1289/ehp7853 · Cited by 45 · see citing works

Significant Reductive Transformation of 6:2 Chlorinated Polyfluorooctane Ether Sulfonate to Form Hydrogen-Substituted Polyfluorooctane Ether Sulfonate and Their Toxicokinetics in Male Sprague–Dawley Rats

Yi, S., Yang, D., Zhu, L. Y., & Mabury, S. A. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c00616 · Cited by 45 · see citing works

Toxicokinetics of perfluorooctanoate (PFOA) in rainbow trout (Oncorhynchus mykiss)

Consoer, D. M., Hoffman, A. D., Fitzsimmons, P. N., Kosian, P. A., & Nichols, J. W. (2014) · Aquatic Toxicology · doi:10.1016/j.aquatox.2014.07.022 · Cited by 45 · see citing works

Systemic toxicity induced by topical application of perfluoroheptanoic acid (PFHpA), perfluorohexanoic acid (PFHxA), and perfluoropentanoic acid (PFPeA) in a murine model

Weatherly, L. M., Shane, H. L., Lukomska, E., Baur, R., & Anderson, S. E. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.113515 · Cited by 45 · see citing works

Pregnancy-induced changes in serum concentrations of perfluoroalkyl substances and the influence of kidney function

Nielsen, C., Hall, U. A., Lindh, C. H., Ekström, U., Xu, Y.-Y., Li, Y., Holmäng, A., & Jakobsson, K. (2020) · Environmental Health · doi:10.1186/s12940-020-00626-6 · Cited by 39 · see citing works

Longitudinal measures of perfluoroalkyl substances (PFAS) in serum of Gullah African Americans in South Carolina: 2003–2013

Gribble, M. O., Bartell, S. M., Kannan, K., Wu, Q., Fair, P. A., & Kamen, D. L. (2015) · Environmental Research · doi:10.1016/j.envres.2015.03.012 · Cited by 43 · see citing works

A review on structural mechanisms of protein-persistent organic pollutant (POP) interactions

Nagar, N., Saxena, H., Pathak, A., Mishra, A., & Poluri, K. M. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.138877 · Cited by 43 · see citing works

Comparison of the toxicokinetics between perfluorocarboxylic acids with different carbon chain length

Ohmori, K., Kudo, N., Katayama, K., & Kawashima, Y. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00573-5 · Cited by 251 · see citing works

Advance Access publication November 13, 2009 Roles of Rat Renal Organic Anion Transporters in Transporting Perfluorinated Carboxylates with Different Chain Lengths

(2009)

Application of physiologically-based pharmacokinetic modeling to explore the role of kidney transporters in renal reabsorption of perfluorooctanoic acid in the rat

Worley, R. R., & Fisher, J. W. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.10.017 · Cited by 76 · see citing works

Roles of Rat Renal Organic Anion Transporters in Transporting Perfluorinated Carboxylates with Different Chain Lengths

Weaver, Y. M., Ehresman, D. J., Butenhoff, J. L., & Hagenbuch, B. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp275 · Cited by 178 · see citing works

Toxicokinetics of perfluoroalkyl carboxylic acids with different carbon chain lengths in mice and humans

Fujii, Y., Niisoe, T., Harada, K. H., Üemoto, S., Ogura, Y., Takenaka, K., & Koizumi, A. (2014) · Journal of Occupational Health · doi:10.1539/joh.14-0136-oa · Cited by 89 · see citing works