The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cell biology and physiology of the uroepithelium
Open accessAbstract
The uroepithelium sits at the interface between the urinary space and underlying tissues, where it forms a high-resistance barrier to ion, solute, and water flux, as well as pathogens. However, the uroepithelium is not simply a passive barrier; it can modulate the composition of the urine, and it functions as an integral part of a sensory web in which it receives, amplifies, and transmits information about its external milieu to the underlying nervous and muscular systems. This review examines our understanding of uroepithelial regeneration and how specializations of the outermost umbrella cell layer, including tight junctions, surface uroplakins, and dynamic apical membrane exocytosis/endocytosis, contribute to barrier function and how they are co-opted by uropathogenic bacteria to infect the uroepithelium. Furthermore, we discuss the presence and possible functions of aquaporins, urea transporters, and multiple ion channels in the uroepithelium. Finally, we describe potential mechanisms by which the uroepithelium can transmit information about the urinary space to the other tissues in the bladder proper.
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Citations
Cites
Membrane Fusion: Grappling with SNARE and SM Proteins
Südhof, T. C., & Rothman, J. E. (2009) · Science · doi:10.1126/science.1161748 · Cited by 2,027
Detection of Intracellular Bacterial Communities in Human Urinary Tract Infection
Rosen, D. A., Hooton, T. M., Stamm, W. E., Humphrey, P. A., & Hultgren, S. J. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040329 · Cited by 651 · cited 1×
“Bacteria not only survive in umbrella cells, but they can also form intracellular bacterial communities (7, 174), which may further serve as reservoirs for recurrent infections.”
BackgroundSetting up a selective barrier at the apical junction complex
Anderson, J. M., Van Itallie, C. M., & Fanning, A. S. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.01.005 · Cited by 215
Cited by
Birder, L., & Andersson, K.-E. (2013) · Physiological Reviews · doi:10.1152/physrev.00030.2012 · Cited by 438
Yanagisawa, H., Kita, Y., Oda, T., & Kikkawa, M. (2023) · Communications Biology · doi:10.1038/s42003-023-05393-x · Cited by 13
Bladder/Pelvic Pain and Neurogenic Inflammation
Birder, L. A. (2019) · Neurourology · doi:10.1007/978-94-017-7509-0_54 · Cited by 3
Metadata
- Authors
- Khandelwal, P., Abraham, S. N., & Apodaca, G.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 2009-12
- Volume
- 297
- Issue
- 6
- Pages
- F1477-F1501
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2110995574
- Cited by
- 379
- References
- 3
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Khandelwal, P., Abraham, S. N., & Apodaca, G. (2009). Cell biology and physiology of the uroepithelium. American Journal of Physiology-Renal Physiology. https://doi.org/10.1152/ajprenal.00327.2009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
