The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.
Urothelial Signaling
Open accessAbstract
The urothelium, which lines the inner surface of the renal pelvis, the ureters, and the urinary bladder, not only forms a high-resistance barrier to ion, solute and water flux, and pathogens, but also functions as an integral part of a sensory web which receives, amplifies, and transmits information about its external milieu. Urothelial cells have the ability to sense changes in their extracellular environment, and respond to chemical, mechanical and thermal stimuli by releasing various factors such as ATP, nitric oxide, and acetylcholine. They express a variety of receptors and ion channels, including P2X3 purinergic receptors, nicotinic and muscarinic receptors, and TRP channels, which all have been implicated in urothelial-neuronal interactions, and involved in signals that via components in the underlying lamina propria, such as interstitial cells, can be amplified and conveyed to nerves, detrusor muscle cells, and ultimately the central nervous system. The specialized anatomy of the urothelium and underlying structures, and the possible communication mechanisms from urothelial cells to various cell types within the bladder wall are described. Changes in the urothelium/lamina propria (“mucosa”) produced by different bladder disorders are discussed, as well as the mucosa as a target for therapeutic interventions.
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Cites
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Mechanisms Underlying Overactive Bladder and Interstitial Cystitis/Painful Bladder Syndrome
Grundy, L., Caldwell, A., & Brierley, S. M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00931 · Cited by 149
Galvez-Sánchez, C. M., Montoro, C. I., Moreno-Padilla, M., Reyes del Paso, G. A., & de la Coba, P. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10122706 · Cited by 45
Bladder/Pelvic Pain and Neurogenic Inflammation
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Self-citation
Metadata
- Authors
- Birder, L., & Andersson, K.-E.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2013-04
- Volume
- 93
- Issue
- 2
- Pages
- 653-680
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W4211052525
- Cited by
- 438
- References
- 180
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
