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Role of matrix metalloproteinases in renal pathophysiologies
Abstract
Matrix metalloproteinases (MMPs) are a large family of proteinases that remodel extracellular matrix (ECM) components and cleave a number of cell surface proteins. MMP activity is regulated via a number of mechanisms, including inhibition by tissue inhibitors of metalloproteinases (TIMPs). Originally thought to cleave only ECM proteins, MMP substrates are now known to include signaling molecules (growth factor receptors) and cell adhesion molecules. Recent data suggest a role for MMPs in a number of renal pathophysiologies, both acute and chronic. This review will focus on the expression and localization of MMPs and TIMPs in the kidney, as well as summarizing the current information linking these proteins to acute kidney injury, glomerulosclerosis/tubulointerstitial fibrosis, chronic allograft nephropathy, diabetic nephropathy, polycystic kidney disease, and renal cell carcinoma.
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Visse, R., & Nagase, H. (2003) · Circulation Research · doi:10.1161/01.res.0000070112.80711.3d · Cited by 4,575
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Mechanisms of Tubulointerstitial Fibrosis
Zeisberg, M., & Neilson, E. G. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010080793 · Cited by 868
The Concise Guide to PHARMACOLOGY 2013/14: Enzymes
Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Spedding, M., Peters, J. A., Harmar, A. J., & Collaborators, C. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12451 · Cited by 425
Extracellular Matrix in Kidney Fibrosis: More Than Just a Scaffold
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Metadata
- Authors
- Catania, J. M., Chen, G., & Parrish, A. R.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 2007-03
- Volume
- 292
- Issue
- 3
- Pages
- F905-F911
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2147104008
- Cited by
- 372
- References
- 1
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Catania, J. M., Chen, G., & Parrish, A. R. (2007). Role of matrix metalloproteinases in renal pathophysiologies. American Journal of Physiology-Renal Physiology. https://doi.org/10.1152/ajprenal.00421.2006
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