Mineralocorticoid effects on cation transport by cortical collecting tubules in vitro
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Schwartz et al. measured K+ flux in the cortical collecting ducts of rabbits at various aldosterone levels.
“Schwartz et al. [34] measured K+ flux in the cortical collecting ducts of rabbits at various ALD levels.”
From A mathematical model of potassium homeostasis: Effect of feedforward and feedback controls (2022) · cites this paper as [34]
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Kellenberger, S. B., & Schild, L. (2002) · Physiological Reviews · doi:10.1152/physrev.00007.2002 · Cited by 1,017 · see citing works
“flux in sodium-deprived or aldosterone-treated animals (41, 204, 221).”
BackgroundSodium-Potassium-Adenosinetriphosphatase-Dependent Sodium Transport in the Kidney: Hormonal Control
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Mammalian Distal Tubule: Physiology, Pathophysiology, and Molecular Anatomy
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Self-citationIntegrated Control of Na Transport along the Nephron
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“CNT/CCD Dietary Na depletion strongly increases Na transport by the CCD measured in vitro (28,29,115) (Figure 5).”
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Epithelial Na+ channels are regulated by flow
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“The mammalian cortical collecting duct (CCD) is a major regulatory site of renal Na(1) reabsorption (36, 46, 48, 53).”
BackgroundSecondary effect of aldosterone on Na-KATPase activity in the rabbit cortical collecting tubule.
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“Another hormone with important actions in the mammalian CCT is aldosterone (7).”
Modulation of cell membrane area in renal collecting tubules by corticosteroid hormones.
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“It has long been accepted that aldosterone is the primary regulator of Na + transport in the late distal tubule and collecting duct (CCT) [9, 20, 24 -26 , 33].”
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Distal tubular segments of the rabbit kidney after adaptation to altered Na- and K-intake
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Enuresis - Background and Treatment
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Hormonal control of renal potassium excretion
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Dietary K+regulates apical membrane expression of maxi-K channels in rabbit cortical collecting duct
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“2) may also be explained by an aldosteroneinduced increase in the apical expression of conducting Na channels (24, 34) and net Na absorption (47), leading to an enhanced electrochemical diving force for K secretion into the urinary fluid.”
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“We are aware of previous experiments utilizing rabbit cortical collecting ducts that showed delayed effects of aldosterone on sodium conductance but that failed to show the immediate effect demonstrated in our whole cell experiments (7, 27, 34).”
BackgroundDistal tubular segments of the rabbit kidney after adaptation to altered Na- and K-intake
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“The relation between the concentration of circulating aldosterone and the magnitude of sodium absorption and potassium secretion was examined by Schwartz and Burg [26].”
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“Chronic elevation of plasma aldosterone has been shown to increase amiloride-sensitive Na transport in the isolated-perfused cortical collecting tubule (CCT) (21, 26, 29) and to increase amiloride-sensitive short-circuit current in the colon (2, 32).”
BackgroundShort-term effect of aldosterone on renal sodium transport and tubular Na?K-ATPase in the rat
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“The a1-isoform is expressed in virtually all cells and most likely represents the “housekeeping” enzyme responsible for maintaining the electrochemical gradients of Na1 and K1 across the plasma membrane (324).”
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“Also, when plasma aldosterone is suppressed by high sodium, low potassium diet, sodium absorption in vitro (CTc) decreases to 50 % of control [13].”
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“Dispersion in the data does exist with regard to the component of sodium reabsorption that is matched by potassium secretion, where a number of reports indicate that this fraction is about one-half (35, 40, 46), whereas others have observed that potassium secretion may be threefourths (35, 52) or one-fourth (35, 54, 5…”
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- Authors
- Schwartz, G. J., & Burg, M. B.
- ORCID
- Schwartz, G. J.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 1978-12-01
- Volume
- 235
- Issue
- 6
- Pages
- F576-F585
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2417442825
- Cited by
- 207
- References
- 0
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Renal Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- mineralocorticoids, cation transport, cortical collecting tubule, renal tubular epithelial cells, sodium transport, potassium transport, aldosterone
- MeSH terms
- Aldosterone, Animals, Bicarbonates, Biological Transport, Active, Calcium, Corticosterone, Dexamethasone, Diet, Sodium-Restricted, Furosemide, Kidney Tubules, Potassium, Rabbits, Sodium, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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