Systemic and renal hemodynamic changes in the luteal phase of the menstrual cycle mimic early pregnancy
Abstract
Blood pressure decreases during early pregnancy in association with a decrease in peripheral vascular resistance and increases in renal plasma flow and glomerular filtration rate. These early changes suggest a potential association with corpora lutea function. To determine whether peripheral vasodilation occurs following ovulation, we studied 16 healthy women in the midfollicular and midluteal phases of the menstrual cycle. A significant decrease in mean arterial pressure in the midluteal phase of the cycle (midfollicular of 81.7 ± 2.0 vs. midluteal of 75.4 ± 2.3 mmHg, P< 0.005) was found in association with a decrease in systemic vascular resistance and an increase in cardiac output. Renal plasma flow and glomerular filtration rate increased. Plasma renin activity and aldosterone concentration increased significantly in the luteal phase accompanied by a decrease in atrial natriuretic peptide concentration. Serum sodium, chloride, and bicarbonate concentrations and osmolarity also declined significantly in the midluteal phase of the menstrual cycle. Urinary adenosine 3′,5′-cyclic monophosphate (cAMP) excretion increased in the luteal compared with the follicular phase, whereas no changes in urinary cGMP or NO 2/NO 3 excretion were found. Thus peripheral vasodilation occurs in the luteal phase of the normal menstrual cycle in association with an increase in renal plasma flow and filtration. Activation of the renin-angiotensin-aldosterone axis is found in the luteal phase of the menstrual cycle. These changes are accompanied by an increase in urinary cAMP excretion indicating potential vasodilating mediators responsible for the observed hemodynamic changes.
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Progesterone has direct effects on energy expenditure through a progesterone-mediated increase in metabolic rate.
“progesterone has direct effects on energy expenditure through a progesterone-mediated increase in metabolic rate [71–73]”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [73]
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- Authors
- Chapman, A. B., Zamudio, S., Woodmansee, W., Merouani, A., Osorio, F., Johnson, A., Moore, L. G., Dahms, T., Coffin, C., Abraham, W. T., & Schrier, R. W.
- Affiliations
- University of Colorado Health Sciences Center, Denver, Colorado 80262
- University of Colorado Denver (US)
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 1997-11-01
- Volume
- 273
- Issue
- 5
- Pages
- F777-F782
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W1819411215
- Cited by
- 201
- References
- 39
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 1 · 2023: 8 · 2022: 11 · 2021: 9 · 2020: 4 · 2019: 12 · 2018: 8 · 2017: 10 · 2016: 6 · 2015: 4 · 2014: 13 · 2013: 11 · 2012: 10
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Renal Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-14985, P01HL014985)
- National Center for Research Resources (MO1-RR-00051-3351, M01RR000051, MO1-RR00051)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- luteal phase, menstrual cycle, early pregnancy, peripheral vasodilation, systemic vascular resistance, renal plasma flow, glomerular filtration rate, mean arterial pressure, cardiac output, renin-angiotensin-aldosterone system, plasma renin activity, aldosterone, atrial natriuretic peptide, urinary cyclic AMP, nitric oxide, corpus luteum, osmolarity
- MeSH terms
- Cyclic AMP, Adult, Aldosterone, Bicarbonates, Blood Pressure, Blood Volume, Cardiac Output, Chlorides, Female, Follicular Phase, Glomerular Filtration Rate, Cyclic GMP, Heart Rate, Hemodynamics, Humans, Luteal Phase, Atrial Natriuretic Factor, Nitrates, Nitrites, Norepinephrine, Pregnancy, Reference Values, Regional Blood Flow, Renal Circulation, Renin, Renin-Angiotensin System, Sodium, Vascular Resistance, Vasodilation
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