The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Distribution of angiotensin AT1and AT2receptor subtypes in the rat kidney
Abstract
ANG II contributes importantly to the regulation of renal vascular resistance, glomerular filtration, and tubular epithelial transport, yet there remains a paucity of information regarding the localization of the ANG II type 1 and 2 (AT 1 and AT 2) receptors within the rat kidney particularly within the vasculature. The present study was designed to localize the transcriptional and translational site(s) of AT 1 and AT 2 receptor (AT 1 R and AT 2 R, respectively) expression within the rat kidney. Using immunohistochemistry, we detected the AT 1 R translational sites throughout the kidney, with the strongest labeling found in the vasculature of the renal cortex and the proximal tubules of the outer medulla. The AT 2 R protein expression was found throughout the rat kidney, although there was little to no expression found in the glomerulus and medullary thick ascending limbs of Henle (TAL). Gene-specific primers were then designed to distinguish between the receptor subtypes within microdissected renal tubular and vascular segments using RT-PCR. AT 1A R, AT 1B R, and AT 2 R mRNA were found within the renal vasculature (afferent arterioles, arcuate artery, and outer medullary descending vasa recta). The mRNA for both the AT 1 R isoforms was also detected in the glomeruli and the renal tubules (proximal tubules, TAL, and collecting ducts); however, no AT 2 R mRNA was detected within the glomerulus and was inconsistently found within the medullary TAL (MTAL). Taken together, these data show that mRNA for the AT 1 R subtypes was located in all of the renal tubular and vascular segments. Evidence for AT 2 R mRNA was also found in all but two of the vascular and tubular segments, the MTAL, and the glomeruli. These results are consistent with the whole tissue immunohistochemically localized receptors.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Angiotensin II receptors and angiotensin II receptor antagonists.
Timmermans, P. B., Wong, P. C., Chiu, A. T., Herblin, W. F., Benfield, P., Carini, D. J., Lee, R. J., Wexler, R. R., Saye, J. A., & Smith, R. D. (1993) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00446-6 · Cited by 1,853
Paracrine regulation of the renal microcirculation
Navar, L. G., Inscho, E. W., Majid, S. A., Imig, J. D., Harrison-Bernard, L. M., & Mitchell, K. D. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.2.425 · Cited by 741
Kambayashi, Y., Bardhan, S., Takahashi, K., Tsuzuki, S., Inui, H., Hamakubo, T., & Inagami, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74499-8 · Cited by 714
Expression of AT2 receptors in the developing rat fetus.
Grady, E. F., Sechi, L. A., Griffin, C. A., Schambelan, M., & Kalinyak, J. E. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115395 · Cited by 535
Siragy, H. M., & Carey, R. M. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119531 · Cited by 485
Angiotensin II type-1 receptor subtype cDNAs: Differential tissue expression and hormonal regulation
Kakar, S. S., Sellers, J. C., Devor, D. C., Musgrove, L. C., & Neill, J. D. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80302-x · Cited by 326
Expression of the Subtype 2 Angiotensin (AT2) Receptor Protein in Rat Kidney
Ozono, R., Wang, Z.-Q., Moore, A. F., Inagami, T., Siragy, H. M., & Carey, R. M. (1997) · Hypertension · doi:10.1161/01.hyp.30.5.1238 · Cited by 317
Cloning and expression of a novel angiotensin II receptor subtype.
Sandberg, K., Ji, H., Clark, A. J., Shapira, H., & Catt, K. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50109-0 · Cited by 274
Harrison-Bernard, L. M., Navar, L. G., Ho, M. M., Vinson, G. P., & el-Dahr, S. S. (1997) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1997.273.1.f170 · Cited by 255
Differential expression of angiotensin receptor 1A and 1B in mouse
Burson, J. M., Aguilera, G., Gross, K. W., & Sigmund, C. D. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.267.2.e260 · Cited by 227
Cited by
Sex-specific differences in hypertension and associated cardiovascular disease
Colafella, K. M. M., & Denton, K. M. (2018) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.189 · Cited by 490
Regulation of Intrarenal Angiotensin II in Hypertension
Navar, L. G., Harrison-Bernard, L. M., Nishiyama, A., & Kobori, H. (2002) · Hypertension · doi:10.1161/hy0202.103821 · Cited by 375
Schrijvers, B. F., De Vriese, A. S., & Flyvbjerg, A. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0018 · Cited by 353
The renin-angiotensin-aldosterone system, glucose metabolism and diabetes
Giacchetti, G., Sechi, L. A., Rilli, S., & Carey, R. M. (2005) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2005.02.003 · Cited by 267
The “His and Hers” of the Renin-Angiotensin System
Hilliard, L. M., Sampson, A. K., Brown, R. D., & Denton, K. M. (2013) · Current Hypertension Reports · doi:10.1007/s11906-012-0319-y · Cited by 228
Metadata
- Authors
- Miyata, N., Park, F., Li, X. F., & Cowley, A. W.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 1999-09-01
- Volume
- 277
- Issue
- 3
- Pages
- F437-F446
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W1852486766
- Cited by
- 270
- References
- 33
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Distribution of angiotensin AT1and AT2receptor subtypes in the rat kidney. https://app.cochat.ai/papers/10.1152/ajprenal.1999.277.3.f437
- The paper
- Miyata, N., Park, F., Li, X. F., & Cowley, A. W. (1999). Distribution of angiotensin AT1and AT2receptor subtypes in the rat kidney. American Journal of Physiology-Renal Physiology. https://doi.org/10.1152/ajprenal.1999.277.3.f437
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
