The DOI matches its Crossref record.
Human cerebral blood flow during sleep and waking.
Abstract
dence that increases in neuronal activity occur during rapid eye movement (REM) sleep. Cerebral metabolic rate is also thought to increase, based on indirect evidence that cerebral blood flow (CBF) is elevated during REM sleep in animals. The present study was designed to evaluate changes in human CBF during normal sleep in 11 young adults. A noninvasive regional CBF method was used involving the clearance of inhaled la3Xe, monitored extracranially. In all regions studied (temporal, precentral, and occipital), CBF in the gray matter tissue compartment varied significantly accord-ing to the sleep or waking state. Depending on the brain region, CBF during REM sleep was elevated 3-12 D/ci above afternoon waking levels. In contrast, CBF during slow wave sleep was re-duced S-14oj. These CBF changes could not be accounted for by variations in arterial COZ or blood pressure and thus may re-flect alterations in brain metabolism or in mechanisms controlling
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Cited by
Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity
Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988) · Science · doi:10.1126/science.3260686 · Cited by 1,796
Functional neuroimaging of normal human sleep by positron emission tomography
Maquet (2000) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2000.00214.x · Cited by 581
Human regional cerebral glucose metabolism during non-rapid eye movement sleep in relation to waking
Nofzinger, E. A., Buysse, D. J., Miewald, J. M., Meltzer, C. C., Price, J. C., Sembrat, R. C., Ombao, H., Reynolds, C. F., Monk, T. H., Hall, M., et al. (2002) · Brain · doi:10.1093/brain/awf103 · Cited by 295
Boyle, P. J., Scott, J. C., Krentz, A. J., Nagy, R. J., Comstock, E., & Hoffman, C. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117003 · Cited by 202
Noble, D. J., & Hochman, S. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01176 · Cited by 160
“, 1999) and reductions in cerebral blood flow during slow wave sleep (Townsend et al., 1973).”
Background
Metadata
- Authors
- Townsend, R. E., Prinz, P. N., & Obrist, W. D.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1973-11
- Volume
- 35
- Issue
- 5
- Pages
- 620-625
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2182128348
- Cited by
- 185
- References
- 0
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Townsend, R. E., Prinz, P. N., & Obrist, W. D. (1973). Human cerebral blood flow during sleep and waking. Journal of Applied Physiology. https://doi.org/10.1152/jappl.1973.35.5.620
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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