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Body temperatures during menopausal hot flashes
Abstract
Body temperatures during hot flashes were measured in a menopausal woman. Internal temperatures fell after each flash; lowest: rectal, 35.6 degrees C; vaginal, 35.6 degrees C; tympanic, 35.2 degrees C. Where sweating occurred, the skin temperature fell during the flash and rose after it. Finger and toe temperatures always showed a sharp rise at the onset of a flash with a slower fall after the flash. Only the cheeks showed additional temperature rises; maximum, 0.7 degrees C. The heart accelerated 13% at the onset of the flash but slowed immediately thereafter. The flash interval was sharply demarcated by undulations in the ECG baseline. There was never any premonitory sign of the imminence of a flash. A central excitatory state seemed to build up, perhaps by the accumulation of a chemical compound, but not of heat, which was explosively dischargedmthe thermal distress was probably evoked by vascular warming in the cheeks. Dabbing the malar prominences with cold water brought prompt relief.
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“After a hot flush is triggered, the core temperature drops (Fig. 3) (Freedman, 2001; Kronenberg, 1990; Molnar, 1975), as expected with the activation of heat dissipation effectors.”
From Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes (2013) · cites this paper as Molnar, 1975
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“Generalized peripheral vasodilatation appears in the first few seconds of the experience and then sweating and an increase in skin electric conductance are observed [19-24].”
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“Characteristics of menopausal hot 'flashes' suggest a disorder ofthe thermoregulatory mechanism (Molnar, 1975; Ginsburg, Swinhoe & O'Reilly, 1981), possibly originating from an excitatory central state established by the discharge of a neurohumour in the thermal centre ofthe brain.”
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Metadata
- Authors
- Molnar, G. W.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1975-03-01
- Volume
- 38
- Issue
- 3
- Pages
- 499-503
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2257282484
- Cited by
- 156
- References
- 0
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 3 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Keywords
- menopausal hot flashes, body temperature, rectal temperature, vaginal temperature, tympanic temperature, skin temperature, heart rate, sweating, menopause
- MeSH terms
- Body Temperature, Cheek, Electrocardiography, Female, Heart Rate, Humans, Menopause, Middle Aged, Skin Temperature, Time Factors
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