The DOI matches its Crossref record.
Effect of aging alone on mechanical properties of the normal adult human lung
Abstract
For plethysmographic studies of respiratory mechanics, we selected, from a general population, 51 subjects, aged 25-75 yr, who had never smoked, had no present or past cardiorespiratory symptoms or disease, were alpha1-antitrypsin MM phenotypes, and were normal by physical examination, vectorcardiography, and chest roentgenography. Approximately equal numbers of men and women were represented in each of three age groups; 25-35, 36-64, and 65-75. Both sexes demonstrated loss of lung elastic recoil with age, most significant at high lung volumes, but the rate of loss was less than previously reported. Males had higher lung recoil than females of comparable age, but if lung size was taken into account, there were no sex differences in bulk elastic properties. Maximum expiratory flow diminished with age only at low volumes, suggesting that equal pressure points are more centrally located at low lung volumes in the elderly.
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In the citing paper
“In the group with an emphysema score greater than 5 we found a linear negative correlation between the extent of emphysema and percent of predicted elastic recoil at 90 O/% total lung capacity (r=-0-696, p<0 01).”
From Elastic recoil changes in early emphysema (1980) · cites this paper as Knudson et al.7
In the citing paper
“By one-way analysis of variance,9 the elastic recoil was decreased in the trace-grade5group compared to the normal group (p<0-01) at all volumes studied and in the grade 5 or greater group was statistically different from normal and the trace-grade 5 group (p<0-01) at all volumes examined when using regression curves obtained from the data of Knudson et al,7 (table 2).”
From Elastic recoil changes in early emphysema (1980) · cites this paper as Knudson et al.7
In the citing paper
“We found a negative correlation between the percentage of predicted elastic recoil and the lung volume (r=-0-612, p<0 01).”
From Elastic recoil changes in early emphysema (1980) · cites this paper as Knudson et al.7
In the citing paper
“A comparison of the percentage of predicted elastic recoil revealed that both emphysema groups were significantly different from normal lungs.”
From Elastic recoil changes in early emphysema (1980) · cites this paper as Knudson et al.7
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Sciurba, F. C., Rogers, R. M., Keenan, R. J., Slivka, W. A., Gorcsan, J., Ferson, P. F., Holbert, J. M., Brown, M. L., & Landreneau, R. J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604253341704 · Cited by 461
Tissue elasticity and the ageing elastic fibre
Sherratt, M. J. (2009) · AGE · doi:10.1007/s11357-009-9103-6 · Cited by 342
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Roupie, É., DAMBROSIO, M., Servillo, G., Mentec, H., Atrous, S. E., Beydon, L., Brun‐Buisson, C., Lemaire, F., & Brochard, L. J. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.1.7599810 · Cited by 321
Incidence of exercise-induced bronchospasm in Olympic winter sport athletes
Wilber, R. L., Rundell, K. W., SZMEDRA, L., JENKINSON, D. M., Im, J., & Drake, S. D. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200004000-00003 · Cited by 265
A simple method to detect expiratory flow limitation during spontaneous breathing
Koulouris, N. G., Valta, P., Lavoie, A., Corbeil, C., Chasse, M., Braidy, J., & Milic‐Emili, J. (1995) · European Respiratory Journal · doi:10.1183/09031936.95.08020306 · Cited by 249
Metadata
- Authors
- Knudson, R. J., Clark, D. F., Kennedy, T. C., & Knudson, D. E.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1977-12-01
- Volume
- 43
- Issue
- 6
- Pages
- 1054-1062
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2336497260
- Cited by
- 197
- References
- 0
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 8 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 2 · 2013: 6 · 2012: 5
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Keywords
- aging, lung elastic recoil, respiratory mechanics, plethysmography, maximal expiratory flow, lung volume, sex differences, older adults, alpha-1-antitrypsin
- MeSH terms
- Adult, Aged, Aging, Female, Humans, Lung, Lung Compliance, Male, Maximal Expiratory Flow Rate, Middle Aged, Sex Factors, Total Lung Capacity, Vital Capacity
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