Mechanism of reduced maximal expiratory flow with aging
Abstract
To investigate the determinants of maximal expiratory flow (MEF) with aging, 17 younger (7 men and 10 women, 39 ± 4 yr, mean ± SD) and 19 older (11 men and 8 women, 69 ± 3 yr) subjects with normal pulmonary function were studied. For further comparison, we also studied 10 middle-aged men with normal lung function (54 ± 6 yr) and 15 middle-aged men (54 ± 7 yr) with mild chronic airflow limitation (CAL; i.e., forced expiratory volume in 1 s/forced vital capacity = 63 ± 8%). MEF, static lung elastic recoil pressure (Pst), and the minimal pressure for maximal flow (Pcrit) were determined in a pressure-compensated, volume-displacement body plethysmograph. Values were compared at 60, 70, and 80% of total lung capacity. In the older subjects, decreases in MEF ( P < 0.01) and Pcrit ( P < 0.05), compared with the younger subjects, were explained mainly by loss of Pst ( P < 0.05). In the CAL subjects, MEF and Pcrit were lower ( P < 0.05) than in the older subjects, but Pst was similar. Thus decreases in MEF and Pcrit were greater than could be explained by the loss of Pst and appeared to be related to increased upstream resistance. These data indicate that the loss of lung recoil explains the decrease in MEF with aging subjects, but not in the mild CAL patients that we studied.
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Elastic recoil of the lungs is reduced with aging and gives rise to an increase in end-expiratory lung volume.
“Elastic recoil of the lungs, due to a reduction in the surface tension forces caused by increased individual diameters of alveoli, is reduced with aging and gives rise to an increase in end-expiratory lung volume (7, 8).”
From Aging and Lung Disease (2020) · cites this paper as [8]
Age-associated changes in the structure, function, and control of the respiratory system can greatly influence COPD susceptibility in older persons.
“Age-associated changes in the structure, function, and control of the respiratory system can greatly influence COPD susceptibility in older persons (6–10).”
From Aging and Lung Disease (2020) · cites this paper as [8]
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Cho, S. J., & Stout-Delgado, H. W. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034610 · Cited by 458 · see citing works
- Authors
- Babb, T. G., & Rodarte, J. R.
- Affiliations
- Baylor College of Medicine (US)
- ORCID
- Babb, T. G.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2000-08-01
- Volume
- 89
- Issue
- 2
- Pages
- 505-511
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2224896588
- Cited by
- 58
- References
- 26
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29ag011805-05)
- National Institute on Aging (AG11805)
- National Heart, Lung, and Blood Institute (HL-07222)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- maximal expiratory flow, aging, lung recoil pressure, critical pressure, chronic airflow obstruction, expiratory resistance, lung elastic recoil, lung function, respiratory mechanics
- MeSH terms
- Adult, Aged, Aging, Female, Humans, Male, Maximal Expiratory Flow Rate, Middle Aged, Respiratory Function Tests, Smoking, Spirometry, Total Lung Capacity, Respiratory Mechanics
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