Changes induced by exercise in rates of turnover and oxidation of ketone bodies in fasting man
Abstract
Seven normal subjects fasted for 3 days were exercised for 30 min on a bicycle ergometer at 60 +/- 30% (mean +/- SE) of their maximal aerobic capacity. Rates of transport and oxidation of ketone bodies were determined at rest and during exercise using a primed constant infusion of [14C]acetoacetate. During the initial 7.5 min of exercise, ketone concentration abruptly decreased (-19.4 +/- 3.1%; P less than 0.001) as the result of a 22.2 +/- 7.0% reduction (P less than 0.05) in ketone production rate (Ra) and a 30.4 +/- 7.5% increase (P less than 0.01) in the rate of uptake (Rd) of ketones. As work progressed, blood ketones continued to fall slowly until the 15th min of exercise and thereafter plateaued at a level which was 21.9 +/- 4.1% lower (P less than 0.005) than resting values. During this apparent new steady state, both Ra and Rd were below control values but tended to be equal and to return simultaneously to their preexercise level. The metabolic clearance rate was increased throughout the entire period of exercise, the rise being more marked during the initial 7.5 min (+40.7 +/- 7.5%; P less than 0.01) than at later periods (+19.0 +/- 7.4%; P less than 0.05). Exercise greatly enhanced ketone oxidation which became virtually complete; despite this, the %CO2 derived from ketones, which averaged 17.6 +/- 1.6% at rest, decreased to 10.1 +/- 0.6% (P less than 0.01) after 30 min of work. This indicates that even during the hyperketonemia of fasting, the increased energy needs related to exercise are met primarily by fuels other than ketones.
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KB disposal into human skeletal muscle is elevated as much as fivefold during exercise.
“established that KB disposal into human skeletal muscle is elevated as much as fivefold during exercise.”
From Metabolism of ketone bodies during exercise and training: physiological basis for exogenous supplementation (2017) · cites this paper as Balasse et al. 1978
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“During ketotic states (i.e., total serum ketones > 500 mM), ketone bodies become significant contributors to energy expenditure and are used in tissues rapidly until uptake or saturation of oxidation occurs (Balasse et al., 1978; Balasse and Féry, 1989; Edmond et al., 1987).”
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“1984) and Fery, Balasse and colleagues (Balasse et al. 1978; Fery & Balasse, 1983, 1986, 1988) established that KB disposal into human skeletal muscle is elevated as much as fivefold during exercise.”
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Kadir, A. A., Clarke, K., & Evans, R. D. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165739 · Cited by 108 · see citing works
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“As reported previously by others in humans and rats (Drury et al., 1941; Balasse et al., 1978; Romijn et al., 1993), the levels of plasma fatty acids and ketone bodies decreased significantly from rest levels in response to a single bout of high-intensity exercise and increased throughout recovery…”
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da Silveira, V. G. (2007) · Americanae (AECID Library)
- Authors
- Balasse, E. O., Fery, F., & Neef, M. A.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1978-01-01
- Volume
- 44
- Issue
- 1
- Pages
- 5-11
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2154644147
- Cited by
- 68
- References
- 0
- Citations by year
- 2025: 5 · 2024: 7 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 5 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- ketone bodies, ketone oxidation, physical activity, fasting, acetoacetate, metabolic clearance rate, ketone production, hyperketonemia, energy metabolism
- MeSH terms
- Acetoacetates, Adult, Physical Exertion, Fasting, Fatty Acids, Nonesterified, Female, Humans, Hydroxybutyrates, Ketone Bodies, Male, Oxidation-Reduction
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