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Measurement of energy expenditure in humans by doubly labeled water method
Abstract
The utility of the doubly labeled water method for the determination of energy expenditure and water output was investigated in humans. Approximately 10 g of 18O and 0.5 g of 2H as water was orally administered to four healthy adults. Total body water was determined from the isotope dilution, and the ensuing 18O and 2H disappearance rates from body water were determined for 13 days by mass spectrometric isotope ratio analysis of the urinary water. During this period, subjects were maintained on a measured diet to determine energy and water intake. The energy expenditure from the doubly labeled water method differed from dietary intake plus change in body composition by an average of 2%, with a coefficient of variation of 6%. The water outputs determined by the two methods differed by 1%, with a coefficient of variation of 7%. The doubly labeled water method is noninvasive, and the subjects could maintain their daily activities without restriction.
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Citations
Cited by
Changes in Energy Expenditure Resulting from Altered Body Weight
Leibel, R. L., Rosenbaum, M., & Hirsch, J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321001 · Cited by 2,012
Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber.
Ravussin, E., Lillioja, S., Anderson, T. E., Christin, L., & Bogardus, C. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112749 · Cited by 1,166
Markers of the Validity of Reported Energy Intake
Livingstone, M. B. E., & Black, A. E. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.3.895s · Cited by 1,081
Strath, S. J., Kaminsky, L. A., Ainsworth, B. E., Ekelund, U., Freedson, P. S., Gary, R. A., Richardson, C. R., Smith, D. T., & Swartz, A. M. (2013) · Circulation · doi:10.1161/01.cir.0000435708.67487.da · Cited by 1,029
Daily activity energy expenditure and mortality among older adults
Manini, T. M., Everhart, J. E., Patel, K. V., Schoeller, D. A., Colbert, L. H., Visser, M., Tylavsky, F., Bauer, D. C., Goodpaster, B. H., & Harris, T. B. (2006) · JAMA · doi:10.1001/jama.296.2.171 · Cited by 598
Self-citation
Metadata
- Authors
- Schoeller, D. A., & van Santen, E.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1982-10-01
- Volume
- 53
- Issue
- 4
- Pages
- 955-959
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2177690176
- Cited by
- 595
- References
- 0
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schoeller, D. A., & van Santen, E. (1982). Measurement of energy expenditure in humans by doubly labeled water method. Journal of Applied Physiology. https://doi.org/10.1152/jappl.1982.53.4.955
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
