Cited by 279Neuroscience of respiration and sleepObstructive Sleep Apnea ResearchHeart Rate Variability and Autonomic Control

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Ventilatory response to sustained hypoxia in normal adults

Easton, P. A., Slykerman, L. J., Anthonisen, N. R.·1986·Journal of Applied Physiology

DOI 10.1152/jappl.1986.61.3.906

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Abstract

We examined the ventilatory response to moderate (arterial O2 saturation 80%), sustained, isocapnic hypoxia in 20 young adults. During 25 min of hypoxia, inspiratory minute ventilation (VI) showed an initial brisk increase but then declined to a level intermediate between the initial increase and resting room air VI. The intermediate level of VI was a plateau that did not change significantly when hypoxia was extended up to 1 h. The relation between the amount of initial increase and subsequent decrease in ventilation during constant hypoxia was not random; the magnitude of the eventual decline correlated confidently with the degree of initial hyperventilation. Evaluation of breathing pattern revealed that during constant hypoxia there was little alteration in respiratory timing and that the changes in VI were related to significant alterations in tidal volume and mean inspiratory flow (VT/TI). None of the changes was reproduced during a sham control protocol, in which room air was substituted for the period of low fractional concentration of inspired O2. We conclude that ventilatory response to hypoxia in adults is not sustained; it exhibits some biphasic features similar to the neonatal hypoxic response.

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Authors: Easton, P. A., Slykerman, L. J., & Anthonisen, N. R.
ORCID: Easton, P. A.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 1986-09-01
Volume: 61
Issue: 3
Pages: 906-911
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/jappl.1986.61.3.906
OpenAlex: W1950707731
Cited by: 278
References: 0
Citations by year: 2026: 1 · 2025: 3 · 2024: 9 · 2023: 4 · 2022: 10 · 2021: 13 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 4
FWCI: 3.16
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords: hypoxic ventilatory response, sustained hypoxia, isocapnic hypoxia, hyperventilation, tidal volume, inspiratory flow, respiratory timing, arterial oxygen saturation
MeSH terms: Adult, Hypoxia, Female, Humans, Inspiratory Capacity, Male, Respiration, Respiratory System, Tidal Volume, Time Factors

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Ventilatory response to sustained hypoxia in normal adults

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