CoChat
Sign Up
Cited by 117Muscle metabolism and nutritionCardiovascular and exercise physiologyAdipose Tissue and Metabolism

The DOI matches its Crossref record.

Acetylcarnitine formation during intense muscular contraction in humans

Harris, R. C., Foster, C. V., Hultman, E.·1987·Journal of Applied Physiology
DOI 10.1152/jappl.1987.63.1.440
Open this paper in CoChat — free account

Abstract

To study the changes in carnitine during intense muscular effort subjects underwent 4 min intermittent electrical stimulation of the quadriceps femoris muscle and on a separate occasion performed 4 min exercise on a bicycle ergometer. Biopsies of the vastus lateralis muscle were taken at rest and after 2 and 4 min of stimulation or exercise. Resting mean muscle total carnitine content was 20.0 mmol/kg dry muscle. Approximately 77% was free carnitine and 19% acetylcarnitine. Four minutes of stimulation or intense exercise did not effect total carnitine but did result in a marked fall in free carnitine and almost equivalent rise in acetylcarnitine. The results indicate that acetylcarnitine is a major metabolite formed during intense muscular effort and that carnitine may function in the regulation of the acetyl-CoA/CoA ratio by buffering excess production of acetyl units.

Overview

Integrity signals

Registry

Crossref · 10.1152/jappl.1987.63.1.440

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cited by

Sorted by citations

See all 117

Related

Metadata

Authors
Harris, R. C., Foster, C. V., & Hultman, E.
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
1987-07-01
Volume
63
Issue
1
Pages
440-442
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.1987.63.1.440
OpenAlex
W2173556929
Cited by
117
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 1 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 4
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords
acetyl-L-carnitine, carnitine metabolism, free carnitine, neuromuscular electrical stimulation, physical activity, quadriceps, vastus lateralis, skeletal muscle
MeSH terms
Acetylcarnitine, Adult, Carnitine, Electric Stimulation, Humans, Kinetics, Male, Muscle Contraction, Muscles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review