The DOI matches its Crossref record.
Strenuous exercise causes systemic endotoxemia
Abstract
Eighteen triathletes were studied before and immediately after competing in an ultradistance triathlon. Their mean plasma lipopolysaccharide (LPS) concentrations increased from 0.081 to 0.294 ng/ml (P less than 0.001), and their mean plasma anti-LPS immunoglobulin G (IgG) concentrations decreased from 67.63 to 38.99 micrograms/ml (P less than 0.001). Both pretriathlon plasma LPS and anti-LPS IgG levels were directly related to the intensity of training (P less than 0.02 and P less than 0.01, respectively). It is possible that training-induced stress led to some leakage of LPS into the circulation, which, in turn, resulted in self-immunization against LPS. The effects on athletic performance in relation to exercise-induced changes in plasma LPS and anti-LPS IgG levels require further investigation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Bouchama, A., & Knochel, J. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmra011089 · Cited by 1,898
Exercise and the immune system: regulation, integration, and adaptation
Pedersen, B. K., & Hoffman-Goetz, L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.1055 · Cited by 1,710
Exertional Heat Illness during Training and Competition
Armstrong, L. E., Casa, D. J., Millard-Stafford, M., Moran, D. S., Pyne, S. W., & Roberts, W. O. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31802fa199 · Cited by 1,019
Guo, S., Al-Sadi, R., Said, H. M., & Ma, T. Y. (2013) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.10.014 · Cited by 719
Clark, A., & Mach, N. (2016) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-016-0155-6 · Cited by 583
“All these studies show that intense exercise during prolonged periods not only can lead to increased intestinal permeability and thus increased plasma LPS levels, but it can also cause immunosuppression [69].”
Background
Metadata
- Authors
- Bosenberg, A. T., Brock-Utne, J. G., Gaffin, S. L., Wells, M. T., & Blake, G. T.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1988-07-01
- Volume
- 65
- Issue
- 1
- Pages
- 106-108
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2182449562
- Cited by
- 222
- References
- 0
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Strenuous exercise causes systemic endotoxemia. https://app.cochat.ai/papers/10.1152/jappl.1988.65.1.106
- The paper
- Bosenberg, A. T., Brock-Utne, J. G., Gaffin, S. L., Wells, M. T., & Blake, G. T. (1988). Strenuous exercise causes systemic endotoxemia. Journal of Applied Physiology. https://doi.org/10.1152/jappl.1988.65.1.106
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
