Cited by 1,898Thermoregulation and physiological responsesHeat shock proteins researchThermal Regulation in Medicine

Heat Stroke

Bouchama, Abderrezak, Knochel, James P.·2002·New England Journal of Medicine

Abstract

Knowledge of the molecular and cellular events in heat stroke has advanced steadily during the past decade. It is now known that heat stroke is associated with injury to multiple tissues and organs as a result not only of the cytotoxic effect of heat, but also of the inflammatory and coagulation responses of the patient. Altered expression of heat-shock proteins may also have a role in the pathogenesis of heat stroke. This article reviews current understanding of the pathophysiology of heat stroke and advances in therapy.

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Crossref · 10.1056/nejmra011089

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81 of 81 references verified0 citation errors · 0 not checkable

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Authors
Bouchama, A., & Knochel, J. P.
Affiliations
King Faisal Specialist Hospital & Research Centre (SA)
Venue
New England Journal of Medicine
Published
2002-06-20
Volume
346
Issue
25
Pages
1978-1988
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W4229653650
Cited by
1,898
References
80
Citations by year
2026: 130 · 2025: 115 · 2024: 97 · 2023: 109 · 2022: 103 · 2021: 106 · 2020: 107 · 2019: 91 · 2018: 91 · 2017: 90 · 2016: 81 · 2015: 100 · 2014: 95 · 2013: 73 · 2012: 67
FWCI
4.26
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
Keywords
heatstroke, pathophysiology, heat shock proteins, cytotoxicity, inflammation, coagulation, tissue damage
MeSH terms
Acute-Phase Reaction, Animals, Blood Coagulation, Body Temperature Regulation, Central Nervous System Diseases, Endothelium, Vascular, Fever, Heat-Shock Proteins, Humans, Multiple Organ Failure, Incidence, Cytokines, Heat Stress Disorders, Heat Stroke

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