Effect of liver glycogen content on glucose production in running rats
Abstract
The influence of supranormal compared with normal hepatic glycogen levels on hepatic glucose production (Ra) during exercise was investigated in chronically catheterized rats. Supranormal hepatic glycogen levels were obtained by a 24-h fast-24-h refeeding regimen. During treadmill running for 35 min at a speed of 21 m/min, Ra and plasma glucose increased more (P less than 0.05) and liver glucogen breakdown was larger in fasted-refed compared with control rats, although the stimuli for Ra were higher in control rats, the plasma concentrations of insulin and glucose being lower (P less than 0.05) in control compared with fasted-refed rats. Also, plasma concentrations of glucagon and both catecholamines tended to be higher and muscle glycogenolysis lower in control compared with fasted-refed rats. Lipid metabolism was similar in the two groups. The results indicate that hepatic glycogenolysis during exercise is directly related to hepatic glycogen content. The smaller endocrine glycogenolytic signal in face of higher plasma glucose concentrations in fasted-refed compared with control rats is indicative of metabolic feedback control of glucose mobilization during exercise. However, the higher exercise-induced increase in Ra, plasma glucose, and liver glycogen breakdown in fasted-refed compared with control rats indicates that metabolic feedback mechanisms are not able to accurately match Ra to the metabolic needs of working muscles.
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Hepatic glycogenolysis is directly related to hepatic glycogen content.
“Indeed, hepatic glycogenolysis is directly related to hepatic glycogen content”
From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [114]
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BackgroundGluconeogenesis and hepatic glycogenolysis during exercise at the lactate threshold
Emhoff, C.-A. W., Messonnier, L. A., Horning, M. A., Fattor, J. A., Carlson, T. J., & Brooks, G. A. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01202.2012 · Cited by 139 · see citing works
“By way of explanation, we note that trained subjects have larger stores of liver glycogen (21), which can be a determinant of hepatic GLY, particularly in states of low glycogen content (22, 45, 55).”
BackgroundGlucose homeostasis during short-term and prolonged exposure to high altitudes.
Woolcott, O., Ader, M., & Bergman, R. (2015) · Endocrine reviews · doi:10.1210/er.2014-1063 · Cited by 123 · see citing works
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Alghannam, A. F., Ghaith, M. M., & Alhussain, M. H. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18094963 · Cited by 104 · see citing works
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Richter, E. A., Turcotte, L. P., Hespel, P., & Kiens, B. (1992) · Diabetes Care · doi:10.2337/diacare.15.11.1767 · Cited by 55 · see citing works
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BackgroundAppetite and blood glucose profiles in humans after glycogen-depleting exercise
Melanson, K. J., Westerterp‐Plantenga, M. S., Campfield, L. A., & Saris, W. H. M. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.3.947 · Cited by 47 · see citing works
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Turcotte, L. P., Rovner, A. S., Roark, R. R., & Brooks, G. A. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.1.e203 · Cited by 27 · see citing works
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“Endurance training in rats increased the hepatic glycogen content,(37) which has been shown to be directly related to hepatic glucose production.(38) Following an overnight fast, 50%–75% of hepatic glucose production was provided by glycogenolysis.”
BackgroundMobilization of glucoregulatory hormones and glucose by hypothalamic locomotor centers
Vissing, J., Iwamoto, G. A., Rybicki, K. J., Galbo, H., & Mitchell, J. H. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.257.5.e722 · Cited by 22 · see citing works
Self-citationA thermodynamic function of glycogen in brain and muscle
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Non-exercising muscle metabolism during exercise
McDermott, J. C., Elder, G. C. B., & Bonen, A. (1991) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00550865 · Cited by 19 · see citing works
“This could be mediated via the ventromedial hypothalamus as in the liver [26], since anatomic mapping has identified connections between the peripheral sympathetic nervous system and the ventromedial hypothalamus [27].”
BackgroundDrouin, R., Robert, G., Milot, M., Massicotte, D., Péronnet, F., & Lavoie, C. (2004) · Metabolism · doi:10.1016/j.metabol.2004.03.010 · Cited by 16 · see citing works
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“For instance, there is one report that higher than normal initial levels of liver glycogen than increase HGP during exercise (24).”
BackgroundMethodological considerations for studies of brain glycogen
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Glucose kinetics during exercise in trained men
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“Hepatic glycogen content has been shown to be directly associated with systemic glucose production during exercise, and, accordingly, hepatic glycogen content is a key determinant of glucose release during exercise (Vissing et al. 1989).”
BackgroundTechnical and Comparative Aspects of Brain Glycogen Metabolism
Wu, L., Butler, N. J. M., & Swanson, R. A. (2019) · Advances in neurobiology · doi:10.1007/978-3-030-27480-1_6 · Cited by 10 · see citing works
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The contribution of afferent signals from the liver to metabolic regulation during exercise
Lavoie, J.-M. (2002) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y02-137 · Cited by 10 · see citing works
“There is one report that higher-than-normal initial levels of liver glycogen increase hepatic glucose production during exercise (Vissing et al. 1989).”
BackgroundThe effects of a high carbohydrate diet on postprandial energy expenditure during exercise in rats
Saitoh, S., Matsuo, T., & Suzuki, M. (1993) · European Journal of Applied Physiology · doi:10.1007/bf00599619 · Cited by 9 · see citing works
“Since elevated liver glycogen directly increased liver glycogenolysis and glucose production (Vissing et al. 1989), increased hepatic glucose production may facilitate muscle glucos e uptake, and consequently enhance glucose oxidation or muscle glycogenesis.”
BackgroundSakurai, T., Takei, M., Ogasawara, J., et al. (2007) · Metabolism · doi:10.1016/j.metabol.2007.05.014 · Cited by 6 · see citing works
“On the other hand, liver glycogen levels would be expected to be higher in RF-EX than in EX-RF rats because hepatic glucose production, hepatic glycogen levels, and plasma glucose were higher in fasted-refed animals than in normally fed and fasted rats [23,24].”
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Sonne, B. (1991) · Clinical Physiology · doi:10.1111/j.1475-097x.1991.tb00812.x · Cited by 4 · see citing works
Hardman, A. E., & Williams, C. (1989) · Journal of Sports Sciences · doi:10.1080/02640418908729831 · Cited by 2 · see citing works
Regulation of Glycemia and Energy Substrate Partitioning in Exercising Humans
Emhoff, C. W. (2013) · eScholarship (California Digital Library) · Cited by 1 · see citing works
Guelfi, K. J. (2006) · UWA Profiles and Research Repository (UWA)
- Authors
- Vissing, J., Wallace, J. L., & Galbo, H.
- Affiliations
- University of Copenhagen (DK)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1989-01-01
- Volume
- 66
- Issue
- 1
- Pages
- 318-322
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2186288485
- Cited by
- 29
- References
- 0
- Citations by year
- 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- liver glycogen, hepatic glucose production, glycogenolysis, physical activity, fasting and refeeding, insulin, glucagon, catecholamines, muscle glycogenolysis, plasma glucose, lipid metabolism, rats
- MeSH terms
- Animals, Catecholamines, Fatty Acids, Nonesterified, Glucose, Glycogen, Lactates, Liver, Male, Pancreatic Hormones, Rats, Inbred Strains, Running, Lactic Acid, Rats
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