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Respiratory sinus arrhythmia in the denervated human heart
Abstract
We performed this study to test whether the denervated human heart has the ability to manifest respiratory sinus arrhythmia (RSA). With the use of a highly sensitive spectral analysis technique (cross correlation) to define beat-to-beat coupling between respiratory frequency and heart rate period (R-R) and hence RSA, we compared the effects of patterned breathing at defined respiratory frequency and tidal volumes (VT), Valsalva and Mueller maneuvers, single deep breaths, and unpatterned spontaneous breathing on RSA in 12 normal volunteers and 8 cardiac allograft transplant recipients. In normal subjects R-R changes closely followed changes in respiratory frequency (P less than 0.001) but were little affected by changes in VT. On the R-R spectrum, an oscillation peak synchronous with respiration was found in heart transplant patients. However, the average magnitude of the respiration-related oscillations was 1.7–7.9% that seen in normal subjects and was proportionally more influenced by changes in VT. Changes in R-R induced by Valsalva and Mueller maneuvers were 3.8 and 4.9% of those seen in normal subjects, respectively, whereas changes in R-R induced by single deep breaths were 14.3% of those seen in normal subjects. The magnitude of RSA was not related to time since the heart transplantation, neither was it related to patient age or sex. Thus the heart has the intrinsic ability to vary heart rate in synchrony with ventilation, consistent with the hypothesis that changes, or rate of changes, in myocardial wall stretch might alter intrinsic heart rate independent of autonomic tone.
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“RSA is seen to be more marked during slow-paced breathing and at lower respiration rates (0.1 Hz and below).”
From Music structure determines heart rate variability of singers (2013) · cites this paper as Bernardi et al., 1989
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Spiegel, K., Knutson, K., Leproult, R., Tasali, E., & Cauter, E. V. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00660.2005 · Cited by 1,175
Metadata
- Authors
- Bernardi, L., Keller, F., Sanders, M., Reddy, P. S., Griffith, B., Meno, F., & Pinsky, M. R.
- Affiliations
- University of Pittsburgh (US)
- ORCID
- Pinsky, M. R.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1989-10-01
- Volume
- 67
- Issue
- 4
- Pages
- 1447-1455
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2218308347
- Cited by
- 272
- References
- 0
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 6 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 6 · 2017: 11 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 9 · 2012: 10
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- respiratory sinus arrhythmia, denervated heart, heart transplantation, cardiac allograft recipients, heart rate variability, respiratory rate, tidal volume, Valsalva maneuver, Mueller maneuver, deep breathing, intrinsic heart rate
- MeSH terms
- Adult, Arrhythmia, Sinus, Denervation, Electrocardiography, Female, Heart, Heart Rate, Humans, Male, Middle Aged, Respiration, Valsalva Maneuver, Heart Transplantation
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