Cited by 272Heart Rate Variability and Autonomic ControlCardiac electrophysiology and arrhythmiasNeuroscience of respiration and sleep

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Respiratory sinus arrhythmia in the denervated human heart

Bernardi, L., Keller, F., Sanders, M., Reddy, P. S., Griffith, B., Meno, F., Pinsky, M. R.·1989·Journal of Applied Physiology

DOI 10.1152/jappl.1989.67.4.1447

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Abstract

We performed this study to test whether the denervated human heart has the ability to manifest respiratory sinus arrhythmia (RSA). With the use of a highly sensitive spectral analysis technique (cross correlation) to define beat-to-beat coupling between respiratory frequency and heart rate period (R-R) and hence RSA, we compared the effects of patterned breathing at defined respiratory frequency and tidal volumes (VT), Valsalva and Mueller maneuvers, single deep breaths, and unpatterned spontaneous breathing on RSA in 12 normal volunteers and 8 cardiac allograft transplant recipients. In normal subjects R-R changes closely followed changes in respiratory frequency (P less than 0.001) but were little affected by changes in VT. On the R-R spectrum, an oscillation peak synchronous with respiration was found in heart transplant patients. However, the average magnitude of the respiration-related oscillations was 1.7–7.9% that seen in normal subjects and was proportionally more influenced by changes in VT. Changes in R-R induced by Valsalva and Mueller maneuvers were 3.8 and 4.9% of those seen in normal subjects, respectively, whereas changes in R-R induced by single deep breaths were 14.3% of those seen in normal subjects. The magnitude of RSA was not related to time since the heart transplantation, neither was it related to patient age or sex. Thus the heart has the intrinsic ability to vary heart rate in synchrony with ventilation, consistent with the hypothesis that changes, or rate of changes, in myocardial wall stretch might alter intrinsic heart rate independent of autonomic tone.

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Authors: Bernardi, L., Keller, F., Sanders, M., Reddy, P. S., Griffith, B., Meno, F., & Pinsky, M. R.
Affiliations: University of Pittsburgh (US)
ORCID: Pinsky, M. R.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 1989-10-01
Volume: 67
Issue: 4
Pages: 1447-1455
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/jappl.1989.67.4.1447
OpenAlex: W2218308347
Cited by: 272
References: 0
Citations by year: 2026: 2 · 2025: 7 · 2024: 6 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 6 · 2017: 11 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 9 · 2012: 10
FWCI: 3.98
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: respiratory sinus arrhythmia, denervated heart, heart transplantation, cardiac allograft recipients, heart rate variability, respiratory rate, tidal volume, Valsalva maneuver, Mueller maneuver, deep breathing, intrinsic heart rate
MeSH terms: Adult, Arrhythmia, Sinus, Denervation, Electrocardiography, Female, Heart, Heart Rate, Humans, Male, Middle Aged, Respiration, Valsalva Maneuver, Heart Transplantation

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Respiratory sinus arrhythmia in the denervated human heart

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