The DOI matches its Crossref record.
Influence of carbohydrate ingestion on fuel substrate turnover and oxidation during prolonged exercise
Abstract
This study examined effects of ingesting a 10% carbohydrate (CHO) drink (CI) or placebo (PI) at 500 ml/h on total (splanchnic) glucose appearance (endogenous+exogenous; Ra), blood glucose oxidation, and muscle glycogen utilization in 14 male endurance-trained cyclists who rode for 180 min at 70% of maximal O2 uptake after CHO loading [starting muscle glycogen 203 +/- 7 (SE) mmol/kg wet wt]. Total CHO oxidation was similar in CI and PI, but Ra increased significantly during the trial in both groups with CI reaching a plateau after 75 min. Ra was significantly greater in CI than in PI at the end of exercise. Blood glucose oxidation also increased significantly during the trial to a plateau in CI and was significantly higher in CI than in PI at the end of exercise. However, mean endogenous Ra was significantly lower in CI than in PI throughout exercise, as was oxidation of endogenous blood glucose, which remained almost constant in CI and reached 43 +/- 8 and 73 +/- 13 mumol.min-1.kg fat-free mass-1 in CI and PI, respectively, at the end of exercise. At 0.83 g/min of CHO ingestion, 0.77 +/- 0.03 g/min was oxidized. Muscle glycogen utilization was identical in both groups and was higher during the 1st h of exercise.(ABSTRACT TRUNCATED AT 250 WORDS)
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“This increases skeletal muscle glucose uptake and therefore plasma glucose oxidation rates (66)”
From Carbohydrate ingestion during prolonged exercise and net skeletal muscle glycogen utilization: A meta-analysis. (2026) · cites this paper as [66]
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Carbohydrate intake during exercise and performance
Jeukendrup, A. E. (2004) · Nutrition · doi:10.1016/j.nut.2004.04.017 · Cited by 490
Oxidation of combined ingestion of glucose and fructose during exercise
Jentjens, R. L. P. G., Moseley, L., Waring, R. H., Harding, L. K., & Jeukendrup, A. E. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00974.2003 · Cited by 310
The use of carbohydrates during exercise as an ergogenic aid
Cermak, N. M., & van Loon, L. J. C. (2013) · Sports Medicine · doi:10.1007/s40279-013-0079-0 · Cited by 300
Jeukendrup, A. E., & Jentjens, R. (2000) · Sports Medicine · doi:10.2165/00007256-200029060-00004 · Cited by 279
Hearris, M., Hammond, K., Fell, J., & Morton, J. (2018) · Nutrients · doi:10.3390/nu10030298 · Cited by 252
Metadata
- Authors
- Bosch, A. N., Dennis, S. C., & Noakes, T. D.
- Affiliations
- University of Cape Town (ZA)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1994-06-01
- Volume
- 76
- Issue
- 6
- Pages
- 2364-2372
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W4241097296
- Cited by
- 107
- References
- 0
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 2 · 2023: 1 · 2022: 3 · 2020: 2 · 2019: 2 · 2018: 3 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- carbohydrate intake, glucose appearance, muscle glycogen utilization, endurance exercise, endurance cyclists, carbohydrate oxidation, substrate metabolism
- MeSH terms
- Adult, Bicycling, Blood Glucose, Carbon Dioxide, Dietary Carbohydrates, Energy Metabolism, Fats, Glucose, Glycogen, Humans, Kinetics, Lactates, Liver, Male, Muscles, Oxidation-Reduction, Oxygen Consumption, Physical Endurance, Exercise, Lactic Acid
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