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Effect of heat stress on muscle energy metabolism during exercise
Open accessAbstract
To examine the effect of heat stress on muscle energy metabolism during submaximal exercise, 12 endurance-trained men cycled on two occasions for approximately 40 min at 70% maximal O2 uptake in an environmental chamber at either 20 degrees C and 20% relative humidity (T20) or 40 degrees C and 20% relative humidity (T40). Trials were conducted > or = 1 wk apart in random order. No difference in mean O2 uptake was observed when exercise in T40 was compared with that in T20. In contrast, exercise in T40 resulted in a higher mean heart rate (P < 0.01) and respiratory exchange ratio (P < 0.05) compared with that in T20. Postexercise rectal and muscle temperatures were also higher (P < 0.01) in T40 than in T20. Lower (P < 0.01) postexercise creatine phosphate and higher creatine (P < 0.01) and ammonia (P < 0.05) were observed in muscle after exercise in T40 compared with T20. In addition, an increased (P < 0.01) muscle glycogenolysis and higher (P < 0.01) postexercise muscle lactate accumulation were observed during exercise in T40 compared with T20. In contrast, no differences were observed in postexercise concentrations of total adenine nucleotide pool (ATP+ADP+AMP), ATP/ADP ratio, or inosine 5'-monophosphate (IMP) when T40 was compared with T20. These results indicate that the rate of ATP utilization may be increased during exercise in the heat but that this increased energy demand is predominantly met by an increase in anaerobic glycolysis and creatine phosphate hydrolysis, preventing a reduction in total adenine nucleotide pool.(ABSTRACT TRUNCATED AT 250 WORDS)
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“Other factors may impact the degradation of muscle glycogen, such as dehydration and hyperthermia [36,95,96,97].”
From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [36]
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Influence of body temperature on the development of fatigue during prolonged exercise in the heat
González‐Alonso, J., Teller, C., Andersen, S. L., Jensen, F. B., Hyldig, T., & Nielsen, B. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.3.1032 · Cited by 1,129
“The detrimental effects of hyperthermia on muscle function and metabolism are well documented (4, 9, 10).”
BackgroundPériard, J. D., Eijsvogels, T. M. H., & Daanen, H. A. M. (2021) · Physiological Reviews · doi:10.1152/physrev.00038.2020 · Cited by 774
Périard, J. D., Racinais, S., & Sawka, M. N. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12408 · Cited by 696
“…which is manifested by high core, skin and brain temperatures, increased cardiovascular strain, a greater reliance on carbohydrate metabolism, and results in reduced aerobic performance (Rowell, 1974; Febbraio et al., 1994a,b; Galloway & Maughan, 1997; Périard et al., 2011b; Nybo et al., 2014).”
BackgroundInfluentialHyperthermia and central fatigue during prolonged exercise in humans
Nybo, L., & Nielsen, B. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.3.1055 · Cited by 623
“The detrimental effects of whole body hyperthermia and high Tmu on muscle metabolism are well documented (12, 23), but these factors seem to play only a minimal role in the development of fatigue during prolonged exercise in hot environments (16, 18, 22).”
BackgroundMEEUSEN, R. R., Watson, P., Hasegawa, H., Roelands, B., & Piacentini, M. F. (2006) · Sports Medicine · doi:10.2165/00007256-200636100-00006 · Cited by 517
Metadata
- Authors
- Febbraio, M. A., Snow, R. J., Stathis, C. G., Hargreaves, M., & Carey, M. F.
- Affiliations
- Victoria University (AU)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1994-12-01
- Volume
- 77
- Issue
- 6
- Pages
- 2827-2831
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2282077497
- Cited by
- 219
- References
- 0
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 11 · 2023: 8 · 2022: 6 · 2021: 14 · 2020: 11 · 2019: 14 · 2018: 12 · 2017: 9 · 2016: 8 · 2015: 16 · 2014: 6 · 2013: 9 · 2012: 9
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- cc-by
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Deakin Research Online (Deakin University) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- heat stress, muscle energy metabolism, submaximal exercise, endurance-trained men, anaerobic glycolysis, phosphocreatine, adenine nucleotide pool, ATP/ADP ratio, inosine 5'-monophosphate, muscle glycogenolysis, ammonia, respiratory exchange ratio, heart rate, muscle temperature, rectal temperature, oxygen absorption
- MeSH terms
- Adult, Anaerobiosis, Energy Metabolism, Physical Exertion, Glycogen, Hot Temperature, Humans, Humidity, Male, Muscles, Phosphates, Stress, Physiological, Temperature
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