The DOI matches its Crossref record.
Effect of heat stress on muscle energy metabolism during exercise
Open accessAbstract
To examine the effect of heat stress on muscle energy metabolism during submaximal exercise, 12 endurance-trained men cycled on two occasions for approximately 40 min at 70% maximal O2 uptake in an environmental chamber at either 20 degrees C and 20% relative humidity (T20) or 40 degrees C and 20% relative humidity (T40). Trials were conducted > or = 1 wk apart in random order. No difference in mean O2 uptake was observed when exercise in T40 was compared with that in T20. In contrast, exercise in T40 resulted in a higher mean heart rate (P < 0.01) and respiratory exchange ratio (P < 0.05) compared with that in T20. Postexercise rectal and muscle temperatures were also higher (P < 0.01) in T40 than in T20. Lower (P < 0.01) postexercise creatine phosphate and higher creatine (P < 0.01) and ammonia (P < 0.05) were observed in muscle after exercise in T40 compared with T20. In addition, an increased (P < 0.01) muscle glycogenolysis and higher (P < 0.01) postexercise muscle lactate accumulation were observed during exercise in T40 compared with T20. In contrast, no differences were observed in postexercise concentrations of total adenine nucleotide pool (ATP+ADP+AMP), ATP/ADP ratio, or inosine 5'-monophosphate (IMP) when T40 was compared with T20. These results indicate that the rate of ATP utilization may be increased during exercise in the heat but that this increased energy demand is predominantly met by an increase in anaerobic glycolysis and creatine phosphate hydrolysis, preventing a reduction in total adenine nucleotide pool.(ABSTRACT TRUNCATED AT 250 WORDS)
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Other factors may impact the degradation of muscle glycogen, such as dehydration and hyperthermia [36,95,96,97].”
From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [36]
Citations
Cited by
Sorted by citations
Influence of body temperature on the development of fatigue during prolonged exercise in the heat
González‐Alonso, J., Teller, C., Andersen, S. L., Jensen, F. B., Hyldig, T., & Nielsen, B. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.3.1032 · Cited by 1,129
“The detrimental effects of hyperthermia on muscle function and metabolism are well documented (4, 9, 10).”
BackgroundPériard, J. D., Eijsvogels, T. M. H., & Daanen, H. A. M. (2021) · Physiological Reviews · doi:10.1152/physrev.00038.2020 · Cited by 774
Périard, J. D., Racinais, S., & Sawka, M. N. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12408 · Cited by 696
“…which is manifested by high core, skin and brain temperatures, increased cardiovascular strain, a greater reliance on carbohydrate metabolism, and results in reduced aerobic performance (Rowell, 1974; Febbraio et al., 1994a,b; Galloway & Maughan, 1997; Périard et al., 2011b; Nybo et al., 2014).”
BackgroundInfluentialHyperthermia and central fatigue during prolonged exercise in humans
Nybo, L., & Nielsen, B. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.3.1055 · Cited by 623
“The detrimental effects of whole body hyperthermia and high Tmu on muscle metabolism are well documented (12, 23), but these factors seem to play only a minimal role in the development of fatigue during prolonged exercise in hot environments (16, 18, 22).”
BackgroundMEEUSEN, R. R., Watson, P., Hasegawa, H., Roelands, B., & Piacentini, M. F. (2006) · Sports Medicine · doi:10.2165/00007256-200636100-00006 · Cited by 517
Tucker, R., Rauch, L., Harley, Y. X. R., & Noakes, T. D. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-004-1267-4 · Cited by 372
“Exercise performance is impaired during both self-paced [16, 35] and externally regulated [5, 7, 25, 26] exercise in the heat.”
BackgroundPerformance in the Heat—Physiological Factors of Importance for Hyperthermia‐Induced Fatigue
Nybo, L., Rasmussen, P., & Sawka, M. N. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130012 · Cited by 405
Consensus recommendations on training and competing in the heat
Racinais, S., Alonso, J. M., Coutts, A. J., Flouris, A. D., Girard, O., González‐Alonso, J., Hausswirth, C., Jay, O., LEE, J. K. W., Mitchell, N., et al. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2015-094915 · Cited by 354
“Given that exercise in the heat increases carbohydrate metabolism [127, 128], endurance athletes should ensure that not only water and sodium losses are replenished, but carbohydrates stores as well [129].”
Temperature and neuromuscular function
Racinais, S., & Oksa, J. (2010) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2010.01204.x · Cited by 326
Nybo, L., & Nielsen, B. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.5.2017 · Cited by 320
“Detrimental effects of hyperthermia on muscle function and on metabolism have been observed, but these factors cannot explain the fatigue that develops during prolonged exercise in hot environments (4, 5, 9, 15, 20, 24).”
BackgroundParkin, J. M., Carey, M. F., Zhao, S., & Febbraio, M. A. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.3.902 · Cited by 260
“Although exercise in the heat often results in an increase in intramuscular glycogen utilization (13, 14, 16), fatigue, in these circumstances, appears to be related to factors other than carbohydrate availability.”
BackgroundResultSelf-citationConsensus recommendations on training and competing in the heat
Racinais, S., Alonso, J. M., Coutts, A. J., Flouris, A. D., Girard, O., González‐Alonso, J., Hausswirth, C., Jay, O., LEE, J. K. W., Mitchell, N., et al. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12467 · Cited by 264
Elevations in core and muscle temperature impairs repeated sprint performance
Drust, B., Rasmussen, P. V., Mohr, M., Nielsen, B., & Nybo, L. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2004.01390.x · Cited by 250
Physiological determinants of endurance exercise performance
Coyle, E. F. (1999) · Journal of science and medicine in sport · doi:10.1016/s1440-2440(99)80172-8 · Cited by 233
Bongers, C. C. W. G., Hopman, M. T. E., & Eijsvogels, T. M. H. (2017) · Temperature · doi:10.1080/23328940.2016.1277003 · Cited by 214
“Cooled muscles have a decreased voluntary power output and might have a reduced anaerobic metabolism during sprint exercise.(43,44) In contrast, endurance exercise includes performance of prolonged activities on a moderate to high intensity, which results in a greater thermoregulatory burden than sprint exercise.”
BackgroundAlterations in Energy Metabolism During Exercise and Heat Stress
Febbraio, M. A. (2001) · Sports Medicine · doi:10.2165/00007256-200131010-00004 · Cited by 192
Self-citationZuo, L., Christofi, F. L., Wright, V. P., Liu, C. Y., Merola, A. J., Berliner, L. J., & Clanton, T. L. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.4.c1058 · Cited by 180
“Finally, elevated temperatures have been shown to result in increased ATP utilization and creatine phosphate depletion (15).”
BackgroundTyler, C. J., Sunderland, C. D., & Cheung, S. S. (2013) · British Journal of Sports Medicine · doi:10.1136/bjsports-2012-091739 · Cited by 174
Sports and environmental temperature: From warming-up to heating-up
Racinais, S., Cocking, S., & Périard, J. D. (2017) · Temperature · doi:10.1080/23328940.2017.1356427 · Cited by 176
“and causes a greater post-exercise accumulation of ammonia as well as muscle and blood lactate.(75,112,114)”
BackgroundEffect of epinephrine on muscle glycogenolysis during exercise in trained men
Febbraio, M. A., Lambert, D. L., Starkie, R. L., Proietto, J., & Hargreaves, M. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.2.465 · Cited by 157
“We have, however, demonstrated that, during 40 min of exercise at 70% V̇O2max in endurance-trained men in 40°C conditions, net muscle glycogen use and circulating epinephrine were elevated, relative to 20°C conditions, without any difference in muscle energy metabolism (9, 10).”
BackgroundSelf-citationContextualising Maximal Fat Oxidation During Exercise: Determinants and Normative Values
Maunder, E., Plews, D. J., & Kilding, A. E. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00599 · Cited by 173
“…increases muscle glycogenolysis, hepatic glucose output, and whole-body carbohydrate oxidation rates, whilst reducing fat oxidation rates at given intensities (Febbraio et al., 1994a,b; Hargreaves Frontiers in Physiology | www.frontiersin.org 6 May 2018 | Volume 9 | Article 599 et al., 1996a).”
BackgroundNutritional Considerations in Triathlon
Jeukendrup, A. E., Jentjens, R. L. P. G., & Moseley, L. (2005) · Sports Medicine · doi:10.2165/00007256-200535020-00005 · Cited by 155
Jentjens, R. L. P. G., Wagenmakers, A. J. M., & Jeukendrup, A. E. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00482.2001 · Cited by 146
“This effect was attributed to increased muscle glycogen utilization, which was associated with higher blood lactate concentrations (14, 15).”
Consensus Recommendations on Training and Competing in the Heat
Racinais, S., Alonso, J. M., Coutts, A. J., Flouris, A. D., Girard, O., González‐Alonso, J., Hausswirth, C., Jay, O., LEE, J. K. W., Mitchell, N., et al. (2015) · Sports Medicine · doi:10.1007/s40279-015-0343-6 · Cited by 148
“Given that exercise in the heat increases carbohydrate metabolism [127, 128], endurance athletes should ensure that not only water and sodium losses are replenished, but carbohydrates stores as well [129].”
IOC consensus statement on recommendations and regulations for sport events in the heat
Racinais, S., Hosokawa, Y., Akama, T., Bermon, S., Bigard, X. A., Casa, D. J., Grundstein, A., Jay, O., Massey, A., Migliorini, S., et al. (2022) · British Journal of Sports Medicine · doi:10.1136/bjsports-2022-105942 · Cited by 147
“7 Postexercise rehydration is achieved through both fluids and foods and should also account for the other losses during exercise such as electrolytes (see next paragraph), carbohydrate 112–114 and amino acids.”
Jentjens, R. L. P. G., Underwood, K., Achten, J., Currell, K., Mann, C. H., & Jeukendrup, A. E. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00322.2005 · Cited by 125
“EXERCISE IN THE HEAT RESULTS in a shift in substrate utilization toward a greater reliance on carbohydrate (CHO) metabolism (13, 17).”
BackgroundEffect of increased muscle temperature on oxygen uptake kinetics during exercise
Koga, S., Shiojiri, T., Kondo, N., & Barstow, T. J. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.4.1333 · Cited by 125
“Pulmonary O2 uptake (V̇O2) has been reported to be higher (24, 27), lower (14, 37), or unchanged (15, 32) in the heat compared with control ambient conditions.”
BackgroundHornery, D. J., Farrow, D., Mujika, I., & YOUNG, W. B. (2007) · Sports Medicine · doi:10.2165/00007256-200737030-00002 · Cited by 127
Cerebral Vascular Control and Metabolism in Heat Stress
Bain, A. R., Nybo, L., & Ainslie, P. N. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140066 · Cited by 131
“A series of seminal studies by Febbraio and colleagues have established that increased muscle temperature is associated with an increased anaerobic metabolism (143-147).”
Regulation of Energy Substrate Metabolism in Endurance Exercise
Alghannam, A. F., Ghaith, M. M., & Alhussain, M. H. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18094963 · Cited by 104
Efficacy of Heat Mitigation Strategies on Core Temperature and Endurance Exercise: A Meta-Analysis
Alhadad, S. B., Tan, P. M. S., & LEE, J. K. W. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00071 · Cited by 102
Relationship between ventilatory response and body temperature during prolonged submaximal exercise
Hayashi, K., Honda, Y., Ogawa, T., et al. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00541.2005 · Cited by 101
Strategies to combat heat strain during and after firefighting
Carter, J. M., Rayson, M. P., Wilkinson, D. M., Richmond, V. L., & Blacker, S. D. (2006) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2006.12.001 · Cited by 98
Nutritional needs for exercise in the heat
Burke, L. M. (2001) · Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology · doi:10.1016/s1095-6433(01)00279-3 · Cited by 84
Cycling in the heat: performance perspectives and cerebral challenges
Nybo, L. (2010) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2010.01211.x · Cited by 80
“, 2008), whereas oxygen consumption remains unchanged during submaximal exercise (Febbraio et al., 1994; Nybo & Nielsen, 2001a).”
BackgroundInfluentialRhoads, R. P., Baumgard, L. H., & Suagee, J. K. (2013) · Journal of Animal Science · doi:10.2527/jas.2012-6120 · Cited by 94
Steensberg, A., van Hall, G., Keller, C., Osada, T., Schjerling, P., Pedersen, B. K., Saltin, B., & Febbraio, M. A. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.015594 · Cited by 78
“They were subsequently extracted and analysed for glycogen, lactate, Cr, CrP and ATP using enzymatic analysis with fluorometric detection, as previously described (Febbraio et al. 1994).”
MethodSelf-citationFernández-Elías, V. E., ORTEGA, J. F., Nelson, R. K., & Mora‐Rodríguez, R. (2015) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3175-z · Cited by 78
Effects of dehydration and rehydration on EMG changes during fatiguing contractions
Bigard, A. X., Sanchez, H., CLAVEYROLAS, G. L., MARTIN, S., THIMONIER, B. T., & Arnaud, M. J. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200110000-00013 · Cited by 74
“Body and muscle temperature are known to influence the development of muscle fatigue (11).”
BackgroundThe effect of passive heating and face cooling on perceived exertion during exercise in the heat
Armada-da-Silva, P. A. S., Woods, J. J., & Jones, D. A. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-003-1006-0 · Cited by 77
“2002), increased muscle and plasma lactate (Febbraio et al. 1994), decreased muscle blood flow (González-Alonso et al.”
BackgroundSkeletal muscle energy metabolism during prolonged, fatiguing exercise
Febbraio, M. A., & Dancey, J. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.6.2341 · Cited by 76
“thine), PCr, and creatine (Cr) as previously described (17).”
MethodSelf-citationPryor, J. L., Johnson, E. C., Roberts, W. O., & Pryor, R. R. (2018) · Temperature · doi:10.1080/23328940.2018.1516537 · Cited by 76
“Should an athlete alter food and fluid intake during heat acclimation? The rate of muscle glycogen depletion is accelerated during exercise in the heat [81].”
BackgroundSports Dietitians Australia Position Statement: Nutrition for Exercise in Hot Environments
McCubbin, A. J., Allanson, B. A., Caldwell Odgers, J. N., Cort, M. M., Costa, R. J. S., Cox, G. R., Crawshay, S. T., Desbrow, B., Freney, E. G., Gaskell, S. K., et al. (2020) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2019-0300 · Cited by 74
“Exertional heat stress also induces greater reliance on muscle glycogen and anaerobic metabolism (Febbraio et al., 1994), which may prematurely deplete endogenous glycogen stores during endurance exercise.”
BackgroundEffects of Dehydration during Cycling on Skeletal Muscle Metabolism in Females
LOGAN-SPRENGER, H. M., HEIGENHAUSER, G. J. F., KILLIAN, K. J., & SPRIET, L. L. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31825abc7c · Cited by 73
High-intensity intermittent running and field hockey skill performance in the heat
Sunderland, C. D., & Nevill, M. E. (2005) · Journal of Sports Sciences · doi:10.1080/02640410410001730197 · Cited by 67
“Further, dehydration and glycogen utilisation have been shown to be greater in the heat (Febbraio et al., 1994) and therefore a greater impairment of skill performance may be observed.”
BackgroundPerformance in the Heat—Physiological Factors of Importance for Hyperthermia‐Induced Fatigue
Nybo, L., Rasmussen, P., & Sawka, M. N. (2014) · Comprehensive physiology · doi:10.1002/j.2040-4603.2014.tb00554.x · Cited by 67
“both muscle glycogen utilization and increased muscle lactate (74, 215) and found that muscle inosine 5′-monophosphate and muscle ammonia accumulation were increased (76,215).”
The effects of passive heating and head-cooling on perception of exercise in the heat
Simmons, S. E., Mündel, T., & Jones, D. A. (2008) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0652-z · Cited by 66
“However, this early onset of fatigue in the heat is also associated with cardiovascular instability and altered metabolism (Dill et al. 1931; Febbraio et al. 1994; Gonzàlez-Alonso et al. 1998a, 1998b).”
BackgroundEffect of CHO ingestion on exercise metabolism and performance in different ambient temperatures
Febbraio, M. A., MURTON, P., Selig, S., Clark, S. A., Lambert, D. L., Angus, D. J., & Carey, M. (1996) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199611000-00006 · Cited by 66
Self-citationMarkers of Muscle Damage and Performance Recovery after Exercise in the Heat
Nybo, L., Girard, O., Mohr, M., Knez, W. L., Voss, S. C., & Racinais, S. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31827ded04 · Cited by 65
Hsu, A. R., Hagobian, T. A., Jacobs, K. A., Attallah, H., & Friedlander, A. L. (2005) · Canadian Journal of Applied Physiology · doi:10.1139/h05-107 · Cited by 58
Sharma, H. S., Sharma, A., Mössler, H., & Muresanu, D. F. (2012) · International review of neurobiology · doi:10.1016/b978-0-12-386986-9.00010-7 · Cited by 59
“Changes in the spontaneous electroencephalogram (EEG) or sensory evoked potentials occur following the rise in brain temperature caused by exercise in hot environment (Dubois et al., 1980, 1981; Febbraio et al., 1994; González-Alonso et al., 1999; Nielsen et al., 2001; see Sharma, 2004).”
Intermittent running: muscle metabolism in the heat and effect of hypohydration
Maxwell, N., Gardner, F., & Nimmo, M. A. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199905000-00009 · Cited by 55
Morris, J. G., Nevill, M. E., Lakomy, H. K. A., Nicholas, C., & Williams, C. (1998) · Journal of Sports Sciences · doi:10.1080/026404198366489 · Cited by 52
Effect of precooling and acclimation on repeat-sprint performance in heat
Brade, C. J., DAWSON, B. T., & Wallman, K. E. (2012) · Journal of Sports Sciences · doi:10.1080/02640414.2012.750006 · Cited by 50
Effects of hyperthermia on the metabolic responses to repeated high-intensity exercise
Linnane, D. M., Bracken, R. M., Brooks, S., Cox, V. M., & Ball, D. R. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-004-1191-5 · Cited by 52
“During 40 min of submaximal exercise in the heat, Febbraio et al. (1994) reported increases in muscle glycogen utilisation and muscle lactate in trained subjects.”
BackgroundBlood–Brain and Spinal Cord Barriers in Stress
SHARMA, H. S. (2004) · Elsevier eBooks · doi:10.1016/b978-012639011-7/50019-x · Cited by 54
CNS fatigue provoked by prolonged exercise in the heat
Nybo, L. (2010) · Frontiers in Bioscience-Elite · doi:10.2741/e138 · Cited by 47
Acute p‐synephrine ingestion increases fat oxidation rate during exercise
Gutiérrez‐Hellín, J., & Coso, J. D. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12952 · Cited by 45
Heat stress decreases metabolic flexibility in skeletal muscle of growing pigs
Zhao, L., McMillan, R. P., Xie, G., Giridhar, S. G. L. W., Baumgard, L. H., El‐Kadi, S. W., Selsby, J. T., Ross, J. J., Gabler, N. K., Hulver, M. W., et al. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00404.2017 · Cited by 44
“Muscle lactate accumulation has been reported in humans and dogs during exercise in the heat, indicating an increase in the conversion of pyruvate to lactate perhaps in lieu of complete glucose oxidation (14, 23, 32, 52).”
BackgroundThe role of fluid temperature and form on endurance performance in the heat
Tan, P. M. S., & LEE, J. K. W. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12366 · Cited by 47
“The negative effects of heat stress on endurance capacity are also well documented in several well-controlled laboratory investigations (Febbraio et al., 1994; Galloway & Maughan, 1997; Parkin et al., 1999).”
BackgroundAbbiss, C. R., Peiffer, J. J., Peake, J. M., Nosaka, K., Suzuki, K., Martin, D. T., & Laursen, P. B. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00683.2007 · Cited by 43
“Furthermore, as hyperthermia is known to increase ATP utilization (17, 18), it is possible that carbohydrate supplementation may be more beneficial during exercise in hot compared with temperate conditions.”
BackgroundErgogenic effects of precooling with cold water immersion and ice ingestion: A meta‐analysis
Choo, H. C., Nosaka, K., Peiffer, J. J., et al. (2017) · European Journal of Sport Science · doi:10.1080/17461391.2017.1405077 · Cited by 43
Substrate Metabolism During Ironman Triathlon: Different Horses on the Same Courses
Maunder, E., Kilding, A. E., & Plews, D. J. (2018) · Sports Medicine · doi:10.1007/s40279-018-0938-9 · Cited by 47
Hyyppä, S., Saastamoinen, M., & Pösö, A. R. (1996) · Equine Veterinary Journal · doi:10.1111/j.2042-3306.1996.tb05038.x · Cited by 43
Pasiakos, S. M. (2020) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-011720-122637 · Cited by 47
The effect of high versus low intensity heat acclimation on performance and neuromuscular responses
Wingfield, G., Gale, R. M., Minett, G. M., Marino, F. E., & Skein, M. (2016) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2016.02.006 · Cited by 49
Nutritional needs of elite endurance athletes. Part I: Carbohydrate and fluid requirements
Tarnopolsky, M. A., Gibala, M., Jeukendrup, A. E., & Phillips, S. M. (2005) · European Journal of Sport Science · doi:10.1080/17461390500076741 · Cited by 39
Sharma, H. S. (2008) · Springer eBooks · doi:10.1007/978-0-387-30375-8_17 · Cited by 44
Heat storage rate and acute fatigue in rats
Rodrigues, L. O. C., Oliveira, A. D. L., Lima, N. R. V., et al. (2003) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2003000100018 · Cited by 39
Thermal Stress Alters Postabsorptive Metabolism During Pre- and Postnatal Development
Johnson, J. S., Abuajamieh, M., Sanz-Fernandez, M. V., Seibert, J. T., Stoakes, S. K., Nteeba, J., Keating, A. F., Ross, J. W., Rhoads, R. P., & Baumgard, L. H. (2015) · Springer eBooks · doi:10.1007/978-81-322-2265-1_5 · Cited by 38
No clear benefit of muscle heating on hypertrophy and strength with resistance training
Stadnyk, A. M. J., Rehrer, N. J., Handcock, P. J., et al. (2017) · Temperature · doi:10.1080/23328940.2017.1391366 · Cited by 38
“Acutely, muscle temperature affects passive and active components of contractility and force transmission,(3,4) and metabolic rate and substrate partitioning.(5,6) Chronically, heat has the potential to protect against atrophy and even produce hypertrophy.”
BackgroundSkeletal muscle volume following dehydration induced by exercise in heat
Hackney, K. J., Cook, S. B., Fairchild, T. J., & Ploutz‐Snyder, L. L. (2012) · Extreme Physiology & Medicine · doi:10.1186/2046-7648-1-3 · Cited by 39
“During exercise in heat, muscle glycogenolysis in the actively contracting skeletal muscle tissue is accelerated [27]; hence, water from decomplexing and that produced from metabolic pathways [28] may be free to move from intracellular into extracellular compartments.”
Programming and regulation of metabolic homeostasis
Wilson, D. F. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00544.2014 · Cited by 34
“7 is also much larger than the little or no change reported by other investigators for similar experimental conditions and work rates (2, 11, 23, 24, 51, 60), including the later papers from the same laboratory.”
BackgroundResultKenefick, R. W., Ely, B. R., Cheuvront, S. N., Palombo, L. J., Goodman, D. A., & Sawka, M. N. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181988c14 · Cited by 34
“Longer, open-ended exercise tests to exhaustion increase performance variability (13) and may introduce the potential for glycogen depletion to separately impact performance outcomes (8).”
BackgroundCosta, R. J. S., Swancott, A. J. M., Gill, S. K., Hankey, J., Scheer, V., Murray, A. M., & Thake, D. (2013) · Coventry University Open Collections (Coventry university) · doi:10.5923/j.sports.20130302.03 · Cited by 31
“blisters, abrasions, sunburn) that accompanies MSUM, individually and in combination have the potential to substantially increase nutrit ional requirements and/or exacerbate factors that would limit overall food and fluid ingestion[3,16,22,23].”
BackgroundMetabolic Priorities During Heat Stress With An Emphasis on Skeletal Muscle
Rhoads, R. P., Baumgard, L. H., & Suagee, J. K. (2013) · Cited by 30
Is There an Optimal Speed for Economical Running?
Black, M. I., Handsaker, J. C., Allen, S. J., Forrester, S., & Folland, J. P. (2017) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.2017-0015 · Cited by 30
Kirby, N. V., Lucas, S. J. E., Armstrong, O. J., Weaver, S. R., & Lucas, R. A. I. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04541-z · Cited by 29
The influence of a hot environment on physiological stress responses in exercise until exhaustion
Silva, R. P. M., de Barros, C. L. M., Mendes, T. T., Garcia, E. S., Valenti, V. E., de Abreu, L. C., Garner, D. M., Espíndola, F. S., & Penha‐Silva, N. (2019) · PLoS ONE · doi:10.1371/journal.pone.0209510 · Cited by 26
“Prolonged exercise commenced in a hot environment can impair the subject’s performance [19], as higher plasma concentrations of epinephrine during exercise elicited by heat induces higher sympathetic activity [20].”
Effect of temperature on muscle metabolism during submaximal exercise in humans
Starkie, R. L., Hargreaves, M., Lambert, D. L., Proietto, J., & Febbraio, M. A. (1999) · Experimental Physiology · doi:10.1111/j.1469-445x.1999.01815.x · Cited by 120
Self-citationDucrocq, G. P., Estrada, J. A., Kim, J. S., et al. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00174.2019 · Cited by 26
Hyperthermia, but not muscle water deficit, increases glycogen use during intense exercise
Fernández-Elías, V. E., Hamouti, N., ORTEGA, J. F., & Mora‐Rodríguez, R. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12368 · Cited by 26
“Furthermore, muscle glycogen use decreases when exercising in the cold (i.e., 3 °C; Febbraio et al., 1994) or when cooling the exercising muscles by applying cold water or ice to the skin (Kozlowski et al., 1985; Starkie et al., 1999).”
BackgroundInfluentialStrategies to mitigate acute kidney injury risk during physical work in the heat
Masoud, A. A., McKenna, Z. J., Li, Z., Deyhle, M. R., Mermier, C. M., Schlader, Z. J., & Amorim, F. T. (2024) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00350.2023 · Cited by 27
Watson, P., Nichols, D. S., & Cordery, P. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0413 · Cited by 24
Pullinger, S. A., Oksa, J., Clark, L. F., et al. (2018) · Chronobiology International · doi:10.1080/07420528.2018.1454938 · Cited by 24
“Such elevations in core temperature have previously been shown to alter and have a detrimental effect on cardiovascular (González-Alonso et al. 2005), metabolic (Brooks et al. 1971; Nybo et al. 2002) and physiological (Febbraio et al. 1994; Hancock and Vasmatzidis 2003) responses to exercise.”
BackgroundExercise intensity regulates the effect of heat stress on substrate oxidation rates during exercise
Maunder, E., Plews, D. J., Mérien, F., & Kilding, A. E. (2019) · European Journal of Sport Science · doi:10.1080/17461391.2019.1674928 · Cited by 24
Functional drinks for athletes
Brouns, F. J. P. H., & Kovacs, E. M. R. (1997) · Trends in Food Science & Technology · doi:10.1016/s0924-2244(97)01098-4 · Cited by 24
López-Torres, O., Rodríguez-Longobardo, C., Escribano-Tabernero, R., & Fernández-Elías, V. E. (2023) · Nutrients · doi:10.3390/nu15204442 · Cited by 23
Heat stress redistributes blood flow in arteries of the brain during dynamic exercise
Sato, K., Oue, A., Yoneya, M., Sadamoto, T., & Ogoh, S. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00353.2015 · Cited by 24
Gough, L. A., Williams, J. J., Newbury, J. W., & Gurton, W. H. (2021) · European Journal of Sport Science · doi:10.1080/17461391.2021.1998644 · Cited by 22
Maunder, E., Plews, D. J., Wallis, G. A., Brick, M. J., Leigh, W. B., Chang, W., Watkins, C. M., & Kilding, A. E. (2021) · Physiological Reports · doi:10.14814/phy2.14849 · Cited by 26
“, 1994), and muscle and plasma lactate accumulation (Febbraio et al., 1994; Maunder, Plews, et al., 2020).”
BackgroundInfluentialHeat Stress‐Mediated Multi‐Organ Injury: Pathophysiology and Treatment Strategies
Ding, X., & Gao, B. (2025) · Comprehensive physiology · doi:10.1002/cph4.70012 · Cited by 30
The Potential Role of Exercise-Induced Muscle Damage in Exertional Heat Stroke
Li, Z., McKenna, Z. J., Kuennen, M. R., Magalhães, F. D. C., Mermier, C. M., & Amorim, F. T. (2021) · Sports Medicine · doi:10.1007/s40279-021-01427-8 · Cited by 22
“It has been well documented that during exercise in the heat, internal skeletal muscle temperature may exceed 40 °C [72, 73].”
BackgroundPark, S., Tokura, H., & Sobajima, M. (2006) · Textile Research Journal · doi:10.1177/0040517506063388 · Cited by 21
“Moreover, it has been suggested that a higher core temperature could cause a greater increase in blood lactic acid concentration during daytime exercise [2, 6, 23].”
BackgroundThe limitations of the constant load and self-paced exercise models of exercise physiology
Marino, F. E. (2012) · Comparative Exercise Physiology · doi:10.3920/cep11012 · Cited by 21
The Impact of Hyperthermia on Receptor-Mediated Interleukin-6 Regulation in Mouse Skeletal Muscle
Welc, S. S., Morse, D. A., Mattingly, A. J., Laitano, O., King, M. A., & Clanton, T. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148927 · Cited by 20
“5–1°C above core temperature [24], reaching values of 41°C in humans [24] and higher (44°C) in rodents [25].”
BackgroundDoes high muscle temperature accentuate skeletal muscle injury from eccentric exercise?
Castellani, J. W., Zambraski, E. J., Sawka, M. N., & Urso, M. L. (2016) · Physiological Reports · doi:10.14814/phy2.12777 · Cited by 20
“However, it has been well documented that during intermittent (Drust et al. 2005; Morris et al. 2005) or continuous (Febbraio et al. 1994a,b) exercise in 33–40°C ambient temperatures, internal muscle temperature may exceed 40°C.”
BackgroundInfluentialYamaguchi, K., Kasai, N., Hayashi, N., Yatsutani, H., Girard, O., & Goto, K. (2020) · Physiological Reports · doi:10.14814/phy2.14466 · Cited by 21
Hayashi, K., Honda, Y., Ogawa, T., et al. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-004-1145-y · Cited by 20
“In addition, the rise in muscle temperature increases intramuscular glycogen breakdown (Febbraio et al. 1994, 1996; Kozlowski et al. 1985), which shortens exercise time.”
BackgroundEffect of Dilute CHO Beverages on Performance in Cool and Warm Environments
Watson, P., Shirreffs, S. M., & Maughan, R. J. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31822dc5ed · Cited by 19
“Although the rate muscle glycogen utilisation is increased during exercise undertaken in warm conditions (15), relatively high muscle glycogen concentrations have been reported at the point of fatigue (35).”
Background
Metadata
- Authors
- Febbraio, M. A., Snow, R. J., Stathis, C. G., Hargreaves, M., & Carey, M. F.
- Affiliations
- Victoria University (AU)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1994-12-01
- Volume
- 77
- Issue
- 6
- Pages
- 2827-2831
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2282077497
- Cited by
- 219
- References
- 0
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 11 · 2023: 8 · 2022: 6 · 2021: 14 · 2020: 11 · 2019: 14 · 2018: 12 · 2017: 9 · 2016: 8 · 2015: 16 · 2014: 6 · 2013: 9 · 2012: 9
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- cc-by
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Deakin Research Online (Deakin University) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- heat stress, muscle energy metabolism, submaximal exercise, endurance-trained men, anaerobic glycolysis, phosphocreatine, adenine nucleotide pool, ATP/ADP ratio, inosine 5'-monophosphate, muscle glycogenolysis, ammonia, respiratory exchange ratio, heart rate, muscle temperature, rectal temperature, oxygen absorption
- MeSH terms
- Adult, Anaerobiosis, Energy Metabolism, Physical Exertion, Glycogen, Hot Temperature, Humans, Humidity, Male, Muscles, Phosphates, Stress, Physiological, Temperature
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
