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Cited by 71Thermoregulation and physiological responsesCardiovascular and exercise physiologyThermal Regulation in Medicine

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Effect of hypoglycemia on thermoregulatory responses

Passias, T. C., Meneilly, G. S., Mekjavic, I. B.·1996·Journal of Applied Physiology
DOI 10.1152/jappl.1996.80.3.1021
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Abstract

The effects of hypoglycemia on sweating, skin blood perfusion, and shivering responses were investigated in 10 healthy male volunteers. They exercised on an underwater cycle ergometer while immersed to the neck in 28 degrees C water for 20 min at 50% of their maximal work rate. The exercise-induced elevation in esophageal temperature (T(es)) initiated the sweating response (Esw) and increased skin blood perfusion (SkBP) as measured at the forehead. In the 99-min postexercise immersion period, the values of T es relative to resting level (delta T(es)) at which Esw abated, SkBP reached preexercise values, and shivering commenced were defined as the delta T(es) thresholds for cessation of sweating, passive vasodilation, and onset of shivering, respectively. Two trials were conducted 1 wk apart. The subject was hypoglycemic in one trial and euglycemic in the other (plasma glucose was maintained at 2.8 and 5 mM, respectively) with the use of the hyperinsulinemic (insulin infusion rate = 60 mU.m-2.min-1) glucose-clamp technique. Oxygen uptake, Esw, T(es), mean skin temperature, heat flux from the skin, and SkBP were recorded at minute intervals. Although heat flux and SkBP attained significantly higher end-exercise levels during euglycemia, the responses were similar during the postexercise cooling period. Hypoglycemia did not affect the Esw response during the exercise and cooling periods. Whereas the exercise delta T(es) response was unaffected by hypoglycemia, the decrease in T(es) was greater (P < or = 0.005) during the hypoglycemic than during the euglycemic condition. Hypoglycemia did not alter the delta T(es) threshold for cessation of sweating and passive vasodilation but reduced (P < or = 0.001) the delta T(es) threshold for onset of shivering (from -0.09 +/- 0.07 degrees C in the euglycemic condition to -0.65 +/- 0.12 degrees C in the hypoglycemic condition). The present results indicate that hypoglycemia (2.8 mM) does not affect the delta T(es) threshold for cessation of thermoregulatory sweating or the threshold for passive vasodilation during recovery from exercise-induced moderate heat stress but that it decreases the core temperature threshold for shivering during cold exposure.

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Crossref · 10.1152/jappl.1996.80.3.1021

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Metadata

Authors
Passias, T. C., Meneilly, G. S., & Mekjavic, I. B.
Affiliations
  • Simon Fraser University (CA)
  • School of Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
ORCID
Meneilly, G. S.
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
1996-03-01
Volume
80
Issue
3
Pages
1021-1032
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.1996.80.3.1021
OpenAlex
W2227190129
Cited by
71
References
23
Citations by year
2026: 1 · 2025: 6 · 2023: 4 · 2022: 2 · 2021: 4 · 2019: 2 · 2017: 1 · 2016: 7 · 2015: 4 · 2014: 4 · 2013: 1 · 2012: 2
FWCI
0.92
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
Keywords
hypoglycemia, thermoregulation, sweating, skin blood perfusion, shivering, esophageal temperature, heat stress, physical activity, hyperinsulinemic-euglycemic clamp, cold exposure, heat flux, underwater exercise, core body temperature, insulin infusion, thermoregulatory set point
MeSH terms
Adult, Blood Glucose, Body Temperature, Body Temperature Regulation, Humans, Hypoglycemia, Hypothermia, Insulin, Male, Oxygen, Skin Physiological Phenomena, Time Factors, Exercise

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