The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Diet-induced insulin resistance precedes other aspects of the metabolic syndrome
Open accessAbstract
This study was designed to examine the effects of a high-fat refined-sugar (HFS) or a low-fat complex-carbohydrate (LFCC) diet on insulin-stimulated skeletal muscle glucose transport, plasma insulin, blood pressure, plasma triglycerides, plasma glycerol, body weight, and body fat in female Fischer rats. Insulin-stimulated glucose transport was significantly reduced in the HFS group at 2 wk, 2 mo, and 2 yr, whereas serum insulin was significantly elevated at all time points. Blood pressure was not significantly elevated in the HFS group until 12 mo, and all HFS animals were hypertensive by 18 mo. Glycerol, triglycerides, and abdominal fat cell size were not significantly different at 2 wk but were significantly elevated in the HFS rats at 2 and 6 mo. Body weight was similar in both groups until 20 wk on the diet, when the HFS rats started to gain more weight. These results demonstrate that insulin resistance and hyperinsulinemia occur before the other manifestations of the metabolic syndrome and that diet, not obesity, is the underlying cause.
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Cites
Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., Brechtel, G., & Baron, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118709 · Cited by 1,687 · cited 1×
“Furthermore, it recently has been demonstrated that insulin-resistant individuals demonstrate endothelial dysfunction (44).”
BackgroundHyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome
Ferrannini, E., Haffner, S. M., Mitchell, B. D., & Stern, M. P. (1991) · Diabetologia · doi:10.1007/bf00403180 · Cited by 898
Splanchnic insulin metabolism in obesity. Influence of body fat distribution.
Peiris, A. N., Mueller, R. A., Smith, G. A., Struve, M. F., & Kissebah, A. H. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112758 · Cited by 346
Increased Insulin Concentrations in Nondiabetic Offspring of Diabetic Parents
Haffner, S. M., Stern, M. P., Hazuda, H. P., Mitchell, B. D., & Patterson, J. K. (1988) · New England Journal of Medicine · doi:10.1056/nejm198811173192001 · Cited by 238
Importance of obesity for the metabolic abnormalities associated with an abdominal fat distribution
Landin, K., Krotkiewski, M., & Smith, U. (1989) · Metabolism · doi:10.1016/0026-0495(89)90219-9 · Cited by 91
Cited by
High-fat diet-induced obesity in animal models
Hariri, N., & Thibault, L. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000168 · Cited by 1,070
Molteni, R., Barnard, R. J., Ying, Z., Roberts, C. K., & Gómez-Pinilla, F. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00123-9 · Cited by 916
Self-citationMetabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training
Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2013) · Comprehensive Physiology · doi:10.1002/cphy.c110062 · Cited by 831
Self-citationAzadbakht, L., Mirmiran, P., Esmaillzadeh, A., Azizi, T., & Azizi, F. (2005) · Diabetes Care · doi:10.2337/diacare.28.12.2823 · Cited by 536
Dietary fats and membrane function: implications for metabolism and disease
Hulbert, A. J., Turner, N., Storlien, L. H., & Else, P. L. (2005) · Biological Reviews · doi:10.1017/s1464793104006578 · Cited by 406
Metadata
- Authors
- Barnard, R. J., Roberts, C. K., Varon, S. M., & Berger, J. J.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1998-04-01
- Volume
- 84
- Issue
- 4
- Pages
- 1311-1315
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2138934442
- Cited by
- 201
- References
- 5
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Barnard, R. J., Roberts, C. K., Varon, S. M., & Berger, J. J. (1998). Diet-induced insulin resistance precedes other aspects of the metabolic syndrome. Journal of Applied Physiology. https://doi.org/10.1152/jappl.1998.84.4.1311
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
